A5088879381- Cerebral Palsy and Movement Disorders
- Botulinum Toxin and Related Neurological Disorders
- Knee injuries and reconstruction techniques
- Hip disorders and treatments
- Sports injuries and prevention
- Family and Disability Support Research
- Shoulder Injury and Treatment
- Bone fractures and treatments
- Nerve Injury and Rehabilitation
- Neurogenetic and Muscular Disorders Research
- Total Knee Arthroplasty Outcomes
- Orthopedic Surgery and Rehabilitation
- Infant Development and Preterm Care
- Osteoarthritis Treatment and Mechanisms
- Lower Extremity Biomechanics and Pathologies
- Stroke Rehabilitation and Recovery
- Elbow and Forearm Trauma Treatment
- Tendon Structure and Treatment
- Muscle Physiology and Disorders
- Neurological disorders and treatments
- Foot and Ankle Surgery
- Occupational Health and Performance
- Shoulder and Clavicle Injuries
- Musculoskeletal Disorders and Rehabilitation
- Hip and Femur Fractures
Rady Children's Hospital-San Diego
2016-2025
University of California, San Diego
2014-2025
Boston Children's Hospital
2003-2025
Harvard University
2025
Foundation for Physical Medicine and Rehabilitation
2023
Allergan (Ireland)
2023
Dermatology Specialists
2008-2023
Seattle Children's Hospital
2022
American Academy of Orthopaedic Surgeons
2011-2021
Addis Ababa University
2021
Autologous bone grafts harvested from the iliac crest are commonly used in reconstructive orthopaedic surgery. is to help promote healing fractures and provide structural support for The results of autologous grafting more predictable than use xenografts, cadaveric allografts, or synthetic substitutes because osteoinductive osteoconductive properties, not immunogenic, usually well incorporated into graft site. In a retrospective review 414 consecutive cases procedures performed at Brooke...
Non‐technical summary Muscle spasticity, due to an upper motoneuron lesion, often leads muscle contractures that limit range of motion and cause increased stiffness. However, the elements responsible for this adaption are unknown. Here we show tissue is stiffer in contracture compared age‐matched children, implicating extracellular matrix (ECM). titin, major load‐bearing protein within fibres, not altered contracture, individual fibre stiffness unaltered. Increased ECM even more functionally...
Background Studies have shown that various biomechanical factors affect valgus extension overload during baseball pitching; yet, their relationships are not clearly defined, and such as trunk rotation arm slot been investigated. Hypothesis The onset of rotation, with other variables define sequential body motion, will significantly predict elbow loading. Study Design Descriptive laboratory study. Methods Sixty-nine adult players pitched off an indoor mound 3-dimensional motion analysis to...
High rotational torques during baseball pitching are believed to be linked most overuse injuries at the shoulder. This study investigated effects of trunk rotation on shoulder pitching. A total 38 pitchers from professional, college, high school, and youth ranks were recruited for motion analysis. Professional demonstrated least amount torque ( p = .001) among skeletally mature players, while exhibiting ability rotate their trunks significantly later in cycle, as compared other groups .01)....
This investigation determined the measurement properties of Pediatric Quality Life Inventory (PedsQL) 3.0 Cerebral Palsy (CP) Module. PedsQL 4.0 Generic Core Scales and CP Module were administered to 245 families. Mean age 134 males 107 females was 8 years 1 month (SD 4y 4mo; range 2–18y). The sample included children with hemiplegia (n=55), diplegia (n=84), quadriplegia (n=85). Twenty eight had a Gross Motor Function Classification System classification at Level I, 40 II, 86 III, 43 IV, 37...
The aim of the study was to determine whether pediatric patients with cerebral palsy (CP; 24.3% hemiplegic, 30.4% diplegic, 38.5% quadriplegic) can self-report their health-related quality life (HRQOL) Pediatric Quality Life Inventory Version 4.0 (PedsQL 4.0) Generic Core Scales. PedsQL administered 148 families (84 males, 64 females; mean 10y, SD 3y 9mo, range 5 18y) recruited from a children's hospital clinic and state medical therapy clinics. Sixty-nine children (47%) were able...
Background: Traditional recommendations hold that open fractures in both children and adults require urgent surgical débridement for a number of reasons, including the preservation soft-tissue viability vascular status as well prevention infection. Following widespread use early administration antibiotics, single-institution studies challenged belief decreases risk acute Methods: We performed retrospective, multicenter study had been treated at six tertiary pediatric medical centers between...
Background. Focal spasticity of the gastrocnemius-soleus muscles causes equinus gait in children with cerebral palsy (CP). Botulinum toxin type A (BTX-A), a neuromuscular blocking agent, reduces muscle tone/overactivity dystonia, stroke, and CP. Objective. prospective, open-label, multicenter clinical trial evaluated long-term safety efficacy repeated intramuscular injections BTX-A on CP children. Methods. Nine centers enrolled 207 (4 U/Kg) were given approximately every 3 months (maximum...
The aim of the study was to determine whether pediatric patients with cerebral palsy (CP; 24.3% hemiplegic, 30.4% diplegic, 38.5% quadriplegic) can self‐report their health‐related quality life (HRQOL) Pediatric Quality Life Inventory Version 4.0 (PedsQL 4.0) Generic Core Scales. PedsQL administered 148 families (84 males, 64 females; mean 10y, SD 3y 9mo, range 5 18y) recruited from a children's hospital clinic and state medical therapy clinics. Sixty‐nine children (47%) were able...
Cerebral palsy (CP) is an upper motor neuron disease that results in a progressive movement disorder. Secondary to the neurological insult, muscles from CP patients often become spastic. Spastic muscle characterized by increased resistance stretch, but develops further complication of contracture which represents prominent disability children with CP. This study's purpose characterize alterations spastic on transcriptional level. Increased knowledge may lead novel therapies improve quality...
Aim Satellite cells are the stem residing in muscle responsible for skeletal growth and repair. Skeletal cerebral palsy (CP) has impaired longitudinal that results contractures. We hypothesized satellite cell population would be reduced contractured muscle. Method compared populations hamstring muscles from participants with CP contracture ( n =8; six males, two females; age range 6–15y; Gross Motor Function Classification System [GMFCS] levels II–V; 4 hemiplegia, diplegia) typically...
From Rady Children's Hospital, San Diego, CA (Dr. Chambers), Department of Orthopaedics, St. Luke's Boise, ID, and the University Utah, Salt Lake City, UT Shea), Vanderbilt Nashville, TN Carey).
Abstract Muscle contractures that occur after upper motor neuron lesion are often surgically released or lengthened. However, surgical manipulation of muscle length changes a muscle's sarcomere ( L s ), which can affect force production. To predict effects surgery, both macro‐ (fascicle f )) and micro‐ ) level structural measurements needed. Therefore, the purpose this study was to quantify in patients with cerebral palsy (CP) as well typically developing (TD) children. Soleus ultrasound...
Background: Small-diameter hamstring tendons are frequently encountered during anterior cruciate ligament (ACL) reconstructions in patients with short stature or those who skeletally immature. The role of augmenting these small-diameter autografts allograft is unclear. Purpose: To assess clinical outcomes and failure rates adolescent small tendon (<7 mm) that were either augmented soft tissue accepted “as is” not augmented. Study Design: Cohort study; Level evidence, 3. Methods: A...