A5058768194- Cerebral Palsy and Movement Disorders
- Botulinum Toxin and Related Neurological Disorders
- Neurogenetic and Muscular Disorders Research
- Nerve Injury and Rehabilitation
- Stroke Rehabilitation and Recovery
- Bone fractures and treatments
- Orthopedic Surgery and Rehabilitation
- Muscle activation and electromyography studies
- Muscle Physiology and Disorders
- Neurological disorders and treatments
- Lower Extremity Biomechanics and Pathologies
- Infant Development and Preterm Care
- Children's Physical and Motor Development
- RNA modifications and cancer
- Peripheral Nerve Disorders
- Family and Disability Support Research
- Congenital limb and hand anomalies
- Neonatal and fetal brain pathology
- Orthopaedic implants and arthroplasty
- Neonatal Respiratory Health Research
- Motor Control and Adaptation
- Parkinson's Disease Mechanisms and Treatments
- Bone Metabolism and Diseases
- Parvovirus B19 Infection Studies
- Extracellular vesicles in disease
Karolinska Institutet
2015-2024
Karolinska University Hospital
2014-2024
GTx (United States)
2011-2019
Sachs' Children and Youth Hospital
2017
Umeå University
1996-2008
Cerebral palsy (CP) is an upper motor neuron disease that results in a progressive movement disorder. Secondary to the neurological insult, muscles from CP patients often become spastic. Spastic muscle characterized by increased resistance stretch, but develops further complication of contracture which represents prominent disability children with CP. This study's purpose characterize alterations spastic on transcriptional level. Increased knowledge may lead novel therapies improve quality...
Abstract Arthrogryposis multiplex congenita (AMC) has been described and defined in thousands of articles, but the terminology used inconsistent clinical research communities. A definition AMC was recently developed using a modified Delphi consensus method involving 25 experts field from 8 countries. Participants included health care professionals, researchers, individuals with AMC. An annotation provides more in‐depth explanations different sentences is useful to complement proposed...
Children with cerebral palsy (CP) and acquired brain injury (ABI) commonly develop muscle contractures advancing age. An underlying growth defect contributing to skeletal contracture formation in CP/ABI has been suggested.The biceps muscles of children adolescents (n = 20) typically developing controls 10) were investigated. We used immunohistochemistry, quantitative real-time polymerase chain reaction, Western blotting assess gene expression relevant size homeostasis.Classical...
Abstract Children with cerebral palsy often have spasticity of both the extensors and flexors, but how why a flexion contracture wrist will develop during growth is not thoroughly understood. In order to understand muscle adaptations that occur formation, relationship between intraoperative sarcomere length extent was measured in 23 children (average age, 14.3 ± 2.9 years) undergoing tendon transfers involving flexor carpi ulnaris (FCU) or extensor radialis brevis (ECRB) muscles. For ECRB...
Morphological properties of skeletal muscle were compared between wrist flexors and extensors within the same children (n = 8, six females, two males; age range 4 to 9y, median 7 y) with imbalance secondary spastic cerebral palsy (CP). Five patients had hemiplegic CP, diplegic one patient tetraplegic CP. Muscle biopsies taken during either tendon transfer or lengthening procedures. Analyses included distribution fibre types, sizes, expression developmental myosins. Extensor area was...
Muscle and joint contact force influence stresses at the proximal growth plate of femur thus bone growth, affecting neck shaft angle (NSA) femoral anteversion (FA). This study aims to illustrate how different muscle groups' activation during gait affects NSA FA development in able-bodied children. Subject-specific models were developed for three children (ages 6, 7, 11 years) using magnetic resonance images. Contributions groups-hip flexors, hip extensors, adductors, abductors, knee...
The objective of the study was to investigate feasibility modified constraint-induced (CI) therapy provided in a 2-week day-camp model with and without intramuscular botulinum toxin type A (BoNT-A) injections for children congenital cerebral palsy. Sixteen hemiplegia, Manual Ability Classification System (MACS) level I II, aged 8–17 years, participated CI day camp; whom five participants (aged 11–16 years) received BoNT-A prior therapy. Assessments were conducted 4 months 2 weeks before...
Abstract Background Individuals with cerebral palsy (CP) are less physically active, spend more time sedentary and have lower cardiorespiratory endurance as compared to typically developed individuals. RaceRunning enables high-intensity exercise in individuals CP limited or no walking ability, using a three-wheeled running bike saddle chest plate for support, but pedals. Training adaptations this type of unknown. Methods Fifteen adolescents/young adults (mean age 16, range 9–29, 7 females/8...
Lower extremity deformities of patients with arthrogryposis multiplex congenita present a wide spectrum severity and deformity combinations. Treatment goals range from merely ensuring comfortable seating shoe wear, to fully independent active ambulation, but the overarching intention is help realize patient's greatest potential for independence function. hip knee contractures dislocations has become more interventional, whereas treatment foot paradoxically much less surgical. This article...
Enormous progress has been made in understanding the etiology and therapies for arthrogryposis (multiple congenital contractures). A 2nd International Symposium on Arthrogryposis was sponsored by Turner Institute St. Petersburg, Russia. Olga Agranovich, Head of Department Institute, organized this special meeting. Care providers from multiple disciplines all over world representing 18 nations attended. Participants included: Pediatric orthopedic specialists, rehabilitation physicians,...
Arthrogryposis is defined as limited range of motion in three or more joints two body parts. This article will describe treatment options for the arthrogrypotic knee. In all types arthrogryposis, and both extension flexion deformities, very early favorable. Just after birth, traction mobilization followed by serial casting could often greatly improve motion. hyperextended knee, surgical lengthening extensor apparatus may be needed. Flexion deformities improved with temporary physeal arrest...
Children with cerebral palsy (CP) often develop reduced passive range of motion age. The determining factor underlying this process is believed to be progressive development contracture in skeletal muscle that likely changes the biomechanics joints. Consequently, identify mechanisms, we modeled mechanical characteristics forearm flexors acting across wrist joint. We investigated strength (Grippit®) and stiffness viscosity 15 typically developing (TD) children (10 boys/5 girls, mean age 12...
The present study was performed to investigate if, in a short term perspective, bimanual hand function children with brain damage improves as an effect of surgery. Assisting Hand Assessment (AHA), Goal Achievement Scale, consolidated House Functional Classification, Zancolli and the active range motion were measured before surgery 5–14 months after 18 children, aged 6–16 years, mean 11 years. AHA improved from 44.5 units (range 20–66) 52.5 25–69) (P<0.005) on 0–100 unit scale. Active...
Arthrogryposis Multiplex Congenita (AMC) is a heterogeneous condition characterized by multiple joint contractures at birth. Greater movements in the trunk and pelvis during walking have been observed children with AMC using orthoses compared to those wearing only shoes. This study investigated gait dynamics identified compensatory mechanisms that accommodate walking.Twenty-six who walked or shoes control group consisting of 37 typically-developing were evaluated 3D analysis. Children...
To provide a detailed gene and protein expression analysis related to mitochondrial biogenesis assess content in skeletal muscle of children with cerebral palsy (CP).Biceps brachii samples were collected from 19 CP (mean [SD] age 15y 4mo [2y 6mo], range 9-18y, 16 males, three females) 10 typically developing comparison [4y], 7-21y, eight two females). Gene (quantitative reverse transcription polymerase chain reaction [PCR]), DNA (mtDNA) genomic ratio PCR), abundance (western blotting)...
In this study, the properties of circulating extracellular vesicles (EVs) were examined in cerebral palsy (CP) and typically developed (TD) individuals at rest after aerobic exercise, focusing on size, concentration, microRNA cargo EVs. Nine adult with CP performed a single exercise bout consisting 45 min Frame Running, TD participants completed either cycling (n = 10; EX) or enrolled as controls no CON). Blood was drawn before 30 analyzed for EV content. The size EVs similar vs. TD, had...
Background Children with cerebral palsy (CP) use their paretic arm less than normal but have a relative overactivity of wrist flexors, causing an impairing flexed position the wrist. Voluntary muscle downregulates myosin heavy chain (MyHC) IIx, it is unclear whether flexors and extensors in children CP affects MyHC expression compared to subjects. Questions/purposes We therefore asked composition differs controls related clinical findings. Methods took biopsies from during hand surgery (n =...