A5044675432- Cerebral Palsy and Movement Disorders
- Muscle Physiology and Disorders
- Botulinum Toxin and Related Neurological Disorders
- Neurogenetic and Muscular Disorders Research
- Bacterial biofilms and quorum sensing
- Muscle activation and electromyography studies
- Family and Disability Support Research
- Pelvic floor disorders treatments
- Pelvic and Acetabular Injuries
- Laser Applications in Dentistry and Medicine
- Micro and Nano Robotics
- Motor Control and Adaptation
- Genetic Neurodegenerative Diseases
- Neurological disorders and treatments
- Cardiomyopathy and Myosin Studies
- Bacterial Genetics and Biotechnology
- Grief, Bereavement, and Mental Health
- Hernia repair and management
- Microfluidic and Bio-sensing Technologies
- Diatoms and Algae Research
- Biochemical and Structural Characterization
University of California, San Diego
2012-2018
La Jolla Bioengineering Institute
2012-2018
University of California System
2015
University of Illinois Urbana-Champaign
2010-2011
Bacterial biofilms are structured multicellular communities involved in a broad range of infections. Knowing how free-swimming bacteria adapt their motility mechanisms near surfaces is crucial for understanding the transition between planktonic and biofilm phenotypes. By translating microscopy movies into searchable databases bacterial behavior, we identified fundamental type IV pili-driven Pseudomonas aeruginosa surface distinct foraging strategies. Bacteria stood upright "walked" with...
Abstract Muscle contractures that occur after upper motor neuron lesion are often surgically released or lengthened. However, surgical manipulation of muscle length changes a muscle's sarcomere ( L s ), which can affect force production. To predict effects surgery, both macro‐ (fascicle f )) and micro‐ ) level structural measurements needed. Therefore, the purpose this study was to quantify in patients with cerebral palsy (CP) as well typically developing (TD) children. Soleus ultrasound...
Cerebral palsy (CP), caused by an injury to the developing brain, can lead alterations in muscle function. Subsequently, increased stiffness and decreased joint range of motion are often seen patients with CP. We examined mechanical biochemical properties gastrocnemius soleus muscles, which involved equinus contracture. Passive testing single fibers from CP undergoing surgery for deformity showed a significant increase fiber (p < 0.01). Bundles that included their surrounding connective...
Abstract We characterized the architecture, fiber type, titin isoform distribution, and collagen content of 27 portions 22 muscles in murine forelimb. The mouse forelimb was different from human arm that it had extensor digitorum lateralis muscle no brachioradialis muscle. Architecturally, differed humans with regard to load bearing, having a much larger contribution extensors than flexors. In mice, : flexor PCSA ratio is 2.7, whereas only 1.4. When architectural difference index calculated,...
Summary In this study, we compare rotator cuff muscle architecture of typically used animal models to humans and quantify the scaling relationships these muscles across mammals. The four that correspond human cuff: supraspinatus, infraspinatus, subscapularis, teres minor, 10 commonly studied animals were excised subjected a series comparative measurements. When body mass among was regressed against PCSA (physiological cross sectional area), mass, normalized fiber length, confidence intervals...
Cerebral palsy (CP) is the most common cause of pediatric neurodevelopmental and physical disability in United States. It defined as a group motor disorders caused by nonprogressive perinatal insult to brain. Although brain lesion nonprogressive, there progressive, lifelong impact on skeletal muscles, which are shorter, spastic, may develop debilitating contractures. Satellite cells resident muscle stem that indispensable for postnatal growth regeneration muscles. Here we measured myogenic...
This study provides global transcriptomic profiling and analysis of botulinum toxin A (BoNT-A)-treated muscle over a 1-year period.Microarray was performed on rat tibialis anterior muscles from 4 groups (n = 4/group) at 1, 4, 12, 52 weeks after BoNT-A injection compared with saline-injected rats 12 weeks.Dramatic transcriptional adaptation occurred 1 week paradoxical increase in expression slow immature isoforms, activation genes competing pathways repair atrophy, impaired mitochondrial...
access to these services among CSHCN have not yet been well described.The objective of this study was examine DME or therapy by (1) identifying the prevalence unmet need, (2) determining sociodemographic and diagnostic characteristics with (3) potential barriers care.Study Design: A cross-sectional utilizing secondary analysis 2009-2010 National Survey Children Special Health Care Needs (NS-CSHCN).Study Participants Setting: The NS-CSHCN is a nationally representative randomly selected...
Here we report the time course of gene expression changes after a single injection botulinum toxin type A (Botox ® , Allergan, Inc., Irvine, CA). Following an approved Institutional Animal Care and Use Committee protocol, 90 male 3‐month‐old Sprague‐Dawley rats were given 100 μL saline containing either 6U/kg Botox or only (control) in their right tibialis anterior (TA) muscle. TAs from four each collected at: 1 week, month, 3 months, year injection, as well 4 control at months. Gene was...
Articles| September 01 1985 Ascending and descending spinal cord tracts M Mathewson Search for other works by this author on: This Site PubMed Google Scholar Crit Care Nurse (1985) 5 (5): 10–14. https://doi.org/10.4037/ccn1985.5.5.10 Views Icon Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Facebook Twitter LinkedIn MailTo Tools Cite Get Permissions Citation Mathewson; tracts. 1 1985; doi: Download citation file: Ris (Zotero) Reference Manager EasyBib...