A5102708446- Wound Healing and Treatments
- Burn Injury Management and Outcomes
- Surgical Sutures and Adhesives
- Reconstructive Surgery and Microvascular Techniques
- Dermatologic Treatments and Research
- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- Pressure Ulcer Prevention and Management
- Orthopedic Surgery and Rehabilitation
- Diabetic Foot Ulcer Assessment and Management
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Laser Applications in Dentistry and Medicine
- Digital Imaging in Medicine
- Cell Adhesion Molecules Research
- Electrospun Nanofibers in Biomedical Applications
- Tendon Structure and Treatment
- Immune Response and Inflammation
- Bone fractures and treatments
- Facial Rejuvenation and Surgery Techniques
- S100 Proteins and Annexins
- Dermatology and Skin Diseases
- Body Contouring and Surgery
- Skin Protection and Aging
- Diagnosis and Treatment of Venous Diseases
- Connexins and lens biology
Film Independent
2022-2025
University of California, San Diego
2001-2019
University of California San Diego Medical Center
2006-2018
UC San Diego Health System
2015-2017
Creative Commons
2016
Plastic Surgery Hospital
2010
University of Lübeck
2009
La Jolla Alcohol Research
2008
Rady Children's Hospital-San Diego
2006
University of Tübingen
2005
Epidermal T cells have been shown to play unique roles in tissue homeostasis and repair mice through local secretion of distinct growth factors the skin. Human epidermis contains both alphabeta(+) gammadelta(+) whose functional capabilities are not understood. We demonstrate that human epidermal able produce insulin-like factor 1 (IGF-1) upon activation promote wound healing a skin organ culture model. Moreover, an analysis isolated from acute versus chronic wounds revealed striking...
Cerebral palsy (CP), caused by an injury to the developing brain, can lead alterations in muscle function. Subsequently, increased stiffness and decreased joint range of motion are often seen patients with CP. We examined mechanical biochemical properties gastrocnemius soleus muscles, which involved equinus contracture. Passive testing single fibers from CP undergoing surgery for deformity showed a significant increase fiber (p < 0.01). Bundles that included their surrounding connective...
The association between injurious falls requiring hospitalization and selected classes of medications was examined in a case-control study nursing home residents. Information for this obtained exclusively from four computerized administrative databases. Over the period April 1987 to March 1992, total 1, 560 first occurred 14, 744 residents Manitoba, Canada, homes who were eligible inclusion study. An fall defined as an injury consequent that resulted admission hospital treatment. Medication...
Patients who have been injured by burns often suffer from persistent and debilitating post burn pruritus. Despite a myriad of therapeutic interventions medications, this complex condition remains particularly difficult to ameliorate. Recently, new generation antipruritic medications has demonstrated clinical success in managing pruritus number dermatologic, nephritic hepatic disease states, targeting unique aspects the pruritic pathways. While specific trials demonstrating efficacy safety...
Effective prevention and treatment of hypertrophic scars (HTSs), a common consequence deep-partial thickness injury, remain significant clinical challenge. Previous studies from our group have shown that autologous adipose-derived regenerative cells (ADRCs) represent promising approach to improve wound healing and, thereby, impact HTS development. The purpose this study was assess the influence local delivery ADRCs immediately following cutaneous injury on development in red Duroc (RD)...
Objective: The use of noncultured autologous stromal vascular fraction or clinical grade adipose-derived regenerative cells (ADRCs) is a promising strategy to promote wound healing and tissue repair. Nevertheless, issues regarding the optimal mode administration remain unclear. purpose this study was compare effects local injection topical spray delivery ADRCs in porcine model thermal burns. Approach: Full-thickness burns were created on dorsum 10 Gottingen minipigs. Two days following...
In an effort to achieve inconspicuous scars, plastic surgeons try place their incisions in established creases and folds of skin. Although well the face abdomen, these folding lines are often disputable on other parts body. Striae distensae always develop perpendicular tension, direction can be used determine optimal incision lines.The authors examined photographs 213 individuals with striae, a composite diagram was created. This along descriptions Langer lines, Pinkus main Kraissl were...
In many clinical trials on cutaneous healing, wound closure is the primary endpoint and single most important outcome parameter, making precise assessment of this time point one utmost importance. The can be performed either by subjective inspection or with a variety methodologies anticipated to provide more objective data. aim study was examine intra- interrater variability blinded photographic analysis human partial thickness wounds, as well reliability remote wounds that direct...
To develop an approach that models the cutaneous healing occurs in a patient with full thickness thermal burn injury complicated by total body radiation exposure sufficient to induce sub-lethal prodromal symptoms. An assessment of effects autologous cell therapy on wound concomitant was used validate utility model.Göttingen minipigs were subjected 1.2 Gy irradiation 6 MV X-ray linear accelerator followed ∼10 cm2 burns (pre-heated brass block calibrated spring). Three days after injury,...