A5048458941- Influenza Virus Research Studies
- Diabetes and associated disorders
- Immune Cell Function and Interaction
- Single-cell and spatial transcriptomics
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- Health, Environment, Cognitive Aging
- T-cell and B-cell Immunology
- Mosquito-borne diseases and control
- Exercise and Physiological Responses
- Respiratory viral infections research
- Viral Infections and Outbreaks Research
- Receptor Mechanisms and Signaling
- Cancer-related molecular mechanisms research
- Body Composition Measurement Techniques
- Vibrio bacteria research studies
- Clinical Nutrition and Gastroenterology
- Intensive Care Unit Cognitive Disorders
- COVID-19 Clinical Research Studies
- Frailty in Older Adults
- Nutrition and Health in Aging
Sanofi (France)
2009-2025
Sanofi (Mexico)
2018
The molecular characterization of immune subsets is important for designing effective strategies to understand and treat diseases. We characterized 29 cell types within the peripheral blood mononuclear (PBMC) fraction healthy donors using RNA-seq (RNA sequencing) flow cytometry. Our dataset was used, first, identify sets genes that are specific, co-expressed, have housekeeping roles across types. Then, we examined differences in mRNA heterogeneity abundance revealing type specificity. Last,...
Evidence suggests the pivotal contribution of nutrition as a modifiable risk factor for sarcopenia. The present cross-sectional study characterized nutritional and metabolic profile sarcopenia through an extensive exploration wide array blood biomarkers related to muscle protein metabolism transcriptomic signatures in community-dwelling elderly adults. Among 189 older individuals with mean age 73.2 years, was diagnosed according Asian Working Group Sarcopenia criteria based on appendicular...
Abstract Background Influenza A(H3N2) viruses exhibit significant genetic diversity and mutations may escape acquired host immunity, potentially triggering infections among vaccinees. This study aims to explore associations between changes in vaccinal status of their adult hosts vaccinated with quadrivalent attenuated standard dose (SD-IIV4) vaccine, recombinant (RIV4) or not vaccinated, alongside exploration other demographics. Overview virus populations characteristics. On the left part is...
Background: Elderly adults over 65 years of age are recommended to receive seasonal influenza vaccination as they at a higher risk infection and its complications than the younger community. The elderly often stratified according frailty status where frail individuals more susceptible adverse health outcomes their non-frail counterparts, however, it is not known whether immunity induced by impaired in elderly. Study Design: Two hundred five subjects Chinese ethnicity Singapore (mean 73.3 ±...
Improving influenza vaccine efficacy is a priority to reduce the burden of influenza-associated morbidity and mortality. By careful selection individuals based on health we show sustained response vaccination in older adults. Sustaining aging could be an important player maintaining immune responses vaccination.NCT03266237. Registered 30 August 2017, https://clinicaltrials.gov/ct2/show/NCT03266237.
The molecular characterization of immune cell types is important for designing and developing effective strategies to understand treat diseases. We characterized 29 different within the peripheral blood mononuclear (PBMC) fraction healthy donors using RNA sequencing (RNA-Seq) flow cytometry. Our RNA-Seq resource has been used first identify set genes that are specific, co-expressed have housekeeping role across types. Then, we analyzed composition each type in terms their relative mRNA...