A5005136928- Malaria Research and Control
- Mosquito-borne diseases and control
- Global Maternal and Child Health
- Viral Infections and Outbreaks Research
- Census and Population Estimation
- Statistical Methods and Bayesian Inference
- Genetic and phenotypic traits in livestock
- Vibrio bacteria research studies
- Influenza Virus Research Studies
- Diabetes and associated disorders
- Pharmacogenetics and Drug Metabolism
- COVID-19 Clinical Research Studies
- Child Nutrition and Water Access
- Bacterial Infections and Vaccines
- Zoonotic diseases and public health
- Immune Response and Inflammation
- Viral gastroenteritis research and epidemiology
- Wikis in Education and Collaboration
- Neonatal Health and Biochemistry
- Diverse Scientific Research Studies
- Child Nutrition and Feeding Issues
- Monoclonal and Polyclonal Antibodies Research
- Respiratory viral infections research
- Disaster Response and Management
- Epilepsy research and treatment
Sanofi (France)
2017-2019
Clinique Pasteur
2018
University of Liverpool
2012-2017
Liverpool School of Tropical Medicine
2012-2017
Malawi-Liverpool-Wellcome Trust Clinical Research Programme
2012-2017
MRC Unit the Gambia
2008-2016
McGill University
2012
Ministry of Health
2012
Michigan State University
2012
University of Malawi
2012
In some areas of Africa, health facility data have indicated declines in malaria that might resulted from increasingly effective control programs. Most such reports been countries where transmission is highly seasonal or modest intensity. Malawi, perennial intense, and measures scaled up during the past decade. We examined for children seen as outpatients parasitemia-positive hospitalized with cerebral a large national hospital. The proportion Plasmodium falciparum-positive slides among...
Abstract Background Individual malaria interventions provide only partial protection in most epidemiological situations. Thus, there is a need to investigate whether combining provides added benefit reducing mortality and morbidity from malaria. The potential benefits of IPT children (IPTc) with home management (HMM) was investigated. Methods During the 2008 transmission season, 1,277 under five years age resident villages within rural Farafenni demographic surveillance system (DSS) North...
Summary Data from multiple prevalence surveys can provide information on common parameters of interest, which therefore be estimated more precisely in a joint analysis than by separate analyses the data each survey. However, fitting single model to combined is inadvisable without testing implicit assumption that all are directed at same inferential target. We propose multivariate generalized linear geostatistical accommodates two sources heterogeneity across correct for spatially structured...
The safety and immunogenicity of PfAMA1, adjuvanted with Alhydrogel® was assessed in malaria–experienced Malian adults. malaria vaccine, PfAMA1-FVO [25-545] is a recombinant protein Pichia pastoris-expressed AMA-1 from Plasmodium falciparum FVO clone adsorbed to Alhydrogel®, the control vaccine tetanus toxoid produced formaldehyde detoxified purified toxin. A double blind randomized controlled phase 1 study enrolled followed 40 healthy adults aged 18–55 years Bandiagara, Mali, West Africa,...
Background Chlorproguanil-dapsone (Lapdap), developed as a low-cost antimalarial, was withdrawn in 2008 after concerns about safety G6PD deficient patients. This trial conducted 2004 to evaluate the and effectiveness of CD comparison with artemether-lumefantrine (AL) under conditions routine use normal patients uncomplicated malaria The Gambia. We also examined effects common genetic variant that affects chlorproguanil metabolism on risk treatment failure. Methods 1238 children aged 6 months...
Here, we report a randomized multicenter phase III trial assessing the lot-to-lot consistency of 2014-2015 Northern Hemisphere quadrivalent split-virion inactivated influenza vaccine (IIV4; Sanofi Pasteur) and comparing its immunogenicity safety with that trivalent (IIV3) in younger older adults (EudraCT no. 2014-000785-21). Younger (18-60 y, n = 1114) (>60 1111) were 2:2:2:1:1 to receive single dose one three lots IIV4, licensed IIV3 containing B Yamagata lineage strain, or an...
In this article, we frame issues around food security and the Ebola epidemic in West Africa discuss potential contribution of interrelated factors like seafood access, bush meat consumption, public health concerns with recent outbreak. Since is a major dietary constituent affected countries, posit that unavailability due to unsustainable fishing practices global change may increase demand for risk exposure zoonosis such as through hunting wildlife interactions. We these contextual drivers...
Improving influenza vaccine efficacy is a priority to reduce the burden of influenza-associated morbidity and mortality. By careful selection individuals based on health we show sustained response vaccination in older adults. Sustaining aging could be an important player maintaining immune responses vaccination.NCT03266237. Registered 30 August 2017, https://clinicaltrials.gov/ct2/show/NCT03266237.
Data from multiple prevalence surveys can provide information on common parameters of interest, which therefore be estimated more precisely in a joint analysis than by separate analyses the data each survey. However, fitting single model to combined is inadvisable without testing implicit assumption that all are directed at same inferential target. In this paper we propose multivariate generalized linear geostatistical accommodates two sources heterogeneity across so as correct for spatially...
Microscopy is generally relied upon for malaria diagnosis and determination of parasite density. However in drug efficacy trials where high throughput screening required, microscopy slow, labour intensive unable to detect low-grade infections reliably. Estimation density antimalarial important as endpoints such time clearance or percentage reduction the initial parasitaemia level allows comparison different combinations. In this study, Real-time Quantitative PCR (qPCR) was used determine an...