A5070116343- Dementia and Cognitive Impairment Research
- Geriatric Care and Nursing Homes
- Intergenerational Family Dynamics and Caregiving
- Palliative Care and End-of-Life Issues
- Frailty in Older Adults
- Context-Aware Activity Recognition Systems
- Nutrition and Health in Aging
- Health disparities and outcomes
- Grief, Bereavement, and Mental Health
- Retinal Imaging and Analysis
- Stroke Rehabilitation and Recovery
- Nutritional Studies and Diet
- Health Systems, Economic Evaluations, Quality of Life
- Family Caregiving in Mental Illness
- Aging, Elder Care, and Social Issues
- Migration, Aging, and Tourism Studies
- Acute Ischemic Stroke Management
- Cerebral Palsy and Movement Disorders
- Aging and Gerontology Research
- Cognitive Functions and Memory
- Balance, Gait, and Falls Prevention
- Chronic Disease Management Strategies
- Glaucoma and retinal disorders
- Intensive Care Unit Cognitive Disorders
- Pressure Ulcer Prevention and Management
Geriatric Education and Research Institute
2016-2025
Khoo Teck Puat Hospital
2016-2025
Nanyang Technological University
2025
Ministry of Agriculture and Agro Based Industry
2023
Singapore General Hospital
2019
Alexandra Hospital
2006-2016
National University of Singapore
2009-2013
Alexandra Hospital
2010
BackgroundIt is important to establish whether frailty among older individuals reversible with nutritional, physical, or cognitive interventions, singly in combination. We compared the effects of 6-month-duration interventions nutritional supplementation, physical training, and combination treatment vs control reducing community-dwelling prefrail frail persons.MethodsWe conducted a parallel group, randomized controlled trial community-living old adults Singapore. The participants' mean age...
Abstract Background Although cerebral small‐vessel disease has been implicated in the development of Alzheimer's (AD), microcirculation is difficult to visualize directly vivo. Because retina provides a noninvasive window assess microcirculation, we determined whether quantitatively measured retinal microvascular parameters are associated with AD. Methods We conducted case‐control study (case:control matching ≈ 1:2). Retinal photographs were analyzed using computer program, and spectrum...
Background: Alzheimer's disease (AD) is a neurodegenerative disorder with emerging evidence that it associated retinal ganglion cell loss; however, few data exist to establish this association. Objective: To determine whether macular
<h3>Importance</h3> The association of the metabolic syndrome (MetS) and component cardiovascular risk factors with developing mild cognitive impairment (MCI) MCI progression to dementia is not well established. <h3>Objective</h3> To investigate MetS its incidence dementia. <h3>Design, Setting, Participants</h3> Prospective longitudinal study from September 1, 2003, through December 31, 2009, in communities 5 districts South East region Singapore. Study participants were a population-based...
This study aims to validate the Zarit Burden Interview as an instrument measure level of burden experienced by caregivers patients with dementia (PWD) in Singapore.Adult family PWD were recruited from ambulatory clinic a tertiary hospital and Alzheimer's Disease Association. All subjects completed battery questionnaires which consisted demographic questions following instruments: (ZBI), Assessment Scale (BAS), General Health Questionnaire (GHQ-28), Dementia Management Strategies (DMSS),...
The independent and combined effects of physical cognitive domains frailty in predicting the development mild impairment (MCI) or dementia are not firmly established. This study included cross-sectional longitudinal analyses (Cardiovascular Health Study criteria), (Mini-Mental State Examination [MMSE]), neurocognitive disorder (DSM-5 criteria) among 1,575 community-living Chinese older adults from Singapore Longitudinal Ageing Studies. At baseline, 2% were frail, 32% prefrail, 9% had (MMSE...
With an ever-growing ageing population, dementia is fast becoming the chronic disease of 21st century. Elderly people affected with progressively lose their autonomy as they encounter problems in Activities Daily Living (ADLs). Hence, need supervision and assistance from family members or professional caregivers, which can often lead to underestimated psychological financial stress for all parties. The use Ambient Assistive (AAL) technologies aims empower relieve burden caregivers.The aim...
To examine the association between marital status and cognitive impairment among community-dwelling Chinese older adults.We analyzed data from 2,498 aged 55 Singapore Longitudinal Aging Study cohort. Cognitive was defined as a Mini-Mental State Examination total score of 23 or below. Odds ratios associations were reported adjusted for potential confounders in logistic regression models.The prevalence 12.2% (n = 306). Being single associated with about 2.5 times increased odds compared to...
<b><i>Aim:</i></b> To investigate the associations between hearing loss and prevalent incident mild cognitive impairment (MCI), dementia MCI <i>or </i>dementia (all cases). <b><i>Methods:</i></b> Cross-sectional longitudinal analyses of baseline follow-up data were performed in a population-based cohort. The sample 2,599 adults aged ≥55 included 1,515 cognitively normal subjects who followed up to 8 years. Hearing at was determined...
Using a sample of dementia caregivers, we compared the diagnostic utility various short versions Zarit Burden Interview (ZBI) with original scale to identify most optimal one. Next, established externally validated cutoffs for ZBI using probable depression cases as reference standard.Caregivers (N = 394; 236 males; Agemean 56 years) were administered and self-report measure. Participants who exceeded cutoff latter identified cases. For each versions, receiver operating characteristic (ROC)...
Objectives: Depression is a common health problem in elderly nursing home (NH) residents and often under-recognized under-treated. This study aimed to determine the prevalence rates of depression identify risk factors associated with NH population Singapore. Methods: A sample 375 six NHs Singapore, aged 55 years above, was assessed Structural Clinical Interview (SCID), based on Diagnostic Statistical Manual Mental Disorders, fourth edition (DSM-IV) criteria. The association demographic,...
Introduction: The detection of systemic risk factors aids in the formulation strategies to prevent multimorbidity and its associated mortality impact. We aimed determine associations inflammatory, metabolic, malnutrition, frailty indexes with onset progression their predictions multimorbidity-associated risk. Methods: A prospective cohort study (Singapore Longitudinal Aging Study [SLAS]) 5,089 community-dwelling older adults aged ≥55 years two waves recruitment (SLAS-1: March 2005-September...
This study aims to determine the prevalence, profile, and severity of neuropsychiatric symptoms (NPS) across dementia continuum their relative impact on caregiver distress quality life (QoL) in persons with (PWD).Six hundred sixty-seven PWD family caregivers presented a memory clinic tertiary hospital 60-month period. Clinicians determined diagnosis using Diagnostic Statistical Manual Mental Disorders, 4th Edition Clinical Dementia Rating scale, respectively. The Neuropsychiatric Inventory...
Background: Indicators of social isolation or support such as living alone, loneliness, being married, and life satisfaction are possible psychosocial risk protective factors for dementia. Objective: We investigate the associations these overlapping with incident MCI-dem entia (neurocognitive disorder) in a population cohort. Methods: Using data from 1601 participants Singapore Longitudinal Ageing Study (SLAS) who were free MCI dementia at baseline followed up to 8 years, we estimated...
Metabolic syndrome (MetS) is reported to be associated with cognitive decline and dementia, in particular vascular dementia. However, the evidence linking MetS Alzheimer's disease (AD) amnestic mild impairment (aMCI), a precursor of
The acute hospital ward can be unfamiliar and stressful for older patients with impaired cognition, rendering them prone to agitation resistive care. Extant literature shows that music therapy enhance engagement mood, thereby ameliorating agitated behaviours. This pilot study evaluates the impact of a creative (CMT) programme on mood in delirium and/or dementia (PtDD) an care setting. We hypothesize CMT improves pleasure these patients.Twenty-five PtDD (age 86.5 ± 5.7 years, MMSE 6/30 5.4)...
Objectives This study aimed to quantify health-related quality of life (HRQoL) loss associated with first episode stroke by comparing patient-reported HRQoL before and after onset. The impact in local population was also evaluated the pre- post-stroke that general population. Methods survivors assessed EQ-5D-3L index score at recruitment, for recalled pre-stroke HRQoL, 3 12 month post-stroke. Change from self-reported 285 238 patients, respectively. Mean EQ each time point (baseline: 464...
Abstract Background Informal caregiving is an integral part of post-stroke recovery with strenuous demands often resulting in burden, threatening sustainability and potentially impacting stroke survivor’s outcomes. Our study aimed to examine quantify objective subjective informal care burden after stroke; explore the factors associated Singapore. Methods Stroke patients their caregivers were recruited from all five tertiary hospitals Singapore December 2010 September 2013. comprised...
Diaper dermatitis and associated infections are common problems that often afflict diaper wearers. These will become more prevalent in the future, as our population ages people need to wear diapers. An urgent solution is therefore needed address these problems. Smart diapers have recently attracted much attention for their potential significantly reduce occurrence of skin infections, by enabling timely change soiled via instant notification. Over past decade, research has focused on...
Global aging populations are facing increased prevalence of mild cognitive impairment (MCI) - the preclinical stage dementia characterized by single/multi-domain neurocognitive decline that does not impair an individual's normal daily functioning. Asian at risk developing MCI and dementia, many cases go undetected in Southeast Asia (SEA), resulting burden on patients, caregivers national healthcare systems. There is urgent need for efficient scalable diagnostic management strategies across...