A5015977944- Dementia and Cognitive Impairment Research
- Neurological Disease Mechanisms and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Functional Brain Connectivity Studies
- Neurological Disorders and Treatments
- Alzheimer's disease research and treatments
- Frailty in Older Adults
- Intracranial Aneurysms: Treatment and Complications
- Retinal Imaging and Analysis
- Cardiovascular Health and Disease Prevention
- Cognitive Functions and Memory
- Traumatic Brain Injury and Neurovascular Disturbances
- Religion, Spirituality, and Psychology
- Family Caregiving in Mental Illness
- Genetics, Bioinformatics, and Biomedical Research
- Sleep and related disorders
- Advanced Neuroimaging Techniques and Applications
- Blood Pressure and Hypertension Studies
- Diet and metabolism studies
- Innovations in Medical Education
- Health disparities and outcomes
- Older Adults Driving Studies
- Social and Intergroup Psychology
- Death Anxiety and Social Exclusion
- Acute Ischemic Stroke Management
Nanyang Technological University
2023-2025
National Neuroscience Institute
2022-2023
James Cook University Singapore
2015-2020
Previous research regarding reflective practice has considered the training and development of skills; little attention been paid to how these are used by clinicians in practice. This study aims understand clinical psychologists experience reflection their day-to-day role. Six practicing Singapore were interviewed experiences. The interviews analysed using Interpretative Phenomenological Analysis. Participants experienced many ways. Reflection helped participants themselves better they...
Global aging populations are facing increased prevalence of mild cognitive impairment (MCI) - the preclinical stage dementia characterized by single/multi-domain neurocognitive decline that does not impair an individual's normal daily functioning. Asian at risk developing MCI and dementia, many cases go undetected in Southeast Asia (SEA), resulting burden on patients, caregivers national healthcare systems. There is urgent need for efficient scalable diagnostic management strategies across...
Mild behavioral impairment (MBI) is one of the earliest observable changes when a person experiences cognitive decline and could be an early manifestation underlying Alzheimer's disease neuropathology. Limited attention has been given to investigating clinical applicability biomarkers for detection prodromal dementia.
Perivascular spaces (PVS) support metabolic clearance in the brain and are increasingly recognized as key contributors to dementia pathogenesis. Plasma-based biomarkers, such glial fibrillary acidic protein (GFAP) amyloid β42/40 (Aβ42/40) ratio, show promise diagnosis but remain understudied vascular cognitive impairment (VCI). VCI, a major global cause of decline, may be more prevalent Southeast Asia. Despite its impact, it is underdiagnosed compared Alzheimer's, highlighting need for...
The use of structural and perfusion brain imaging in combination with behavioural information the prediction cognitive syndromes using a data-driven approach remains to be explored. Here, we thus examined contribution features existing classification approach.
Abstract Background White matter hyperintensities, a neuroimaging marker of small-vessel cerebrovascular disease and apolipoprotein ε4 (APOE4) allele, are important dementia risk factors. However, APOE4 as key effect modifier in the relationship between white hyperintensities grey volume needs further exploration. Methods One hundred ninety-two early-stage (including mild cognitive impairment dementia) 259 cognitively unimpaired participants from neurocognitive research cohort with data,...
Abstract Background Perivascular spaces (PVS) are fluid‐filled in the brain, hypothesized promoting clearance of metabolites implicated dementia through glymphatic system drainage. PVS classified according to Grades (0‐4). Blood‐based biomarkers including Glial fibrillary acidic protein (GFAP), Amyloid β 42/40 (Aβ42/40) ratio have shown promise diagnosing and prognosing dementia. However, association between blood‐based remains relatively unexplored Vascular Cognitive Impairment (VCI)...
Background: A delay in the detection of mild cognitive impairment (MCI) community delays opportunity for early intervention. Accurate tools to detect MCI are lacking. The Visual Cognitive Assessment Test (VCAT) is a visual based test useful multilingual populations without need translation. Objective: Here, we evaluate usefulness VCAT detecting population Singapore. Methods: We recruited 301 participants from who completed detailed neuropsychological assessment and 170 them 3T magnetic...
Abstract Background Dementia affects 55 million people worldwide, with 60% of the burden in Asia. White Matter Hyperintensities (WMH) is a key marker small vessel disease, high prevalence Asian populations prodromal and clinical dementia. WMH described as: Deep (DWMH), Periventricular (PVH) or Fazekas‐Total (DWMH PVH). However, association between topography performance specific cognitive domains remains unexplored. Thus, this study aims to characterise impact Fazekas‐Total, DWMH PVH on...
This article reports 7 studies showing that God primes inhibit self-concept accessibility. Study 1A provided the first supportive evidence using undergraduate samples. 1B replicated findings working adult participants. 2A to 2C showed inhibitory effect of concept on implicit self-concepts was not due concepts related love, power, hope, religion, devil, and father. 3 found same when prime subliminally presented. 4 priming influenced self-representations, but other types representations....
Cardiovascular risk factors (CRFs) such as hypertension, high cholesterol, and diabetes are increasingly implicated in cognitive decline cerebral small vessel disease (cSVD). White matter hyperintensities (WMH), a hallmark of cSVD, strongly linked to impairment, but their underlying mechanisms remain unclear. Blood-brain barrier (BBB) dysfunction has been proposed potential contributor WMH development. This study aimed explore the relationships between CRFs, BBB integrity, burden. We...
Abstract Background Integrating behavioural assessments with blood-based biomarkers (BBM) could improve diagnostic accuracy for Mild Cognitive Impairment (MCI) linked to early-stage neurodegenerative disease (NDD). This study investigates the potential of combining neuropsychiatric symptoms (NPS) BBM enhance differentiation between older adults MCI and those Normal Cognition (NC) in a multi-ethnic Southeast Asian cohort. Methods cross-sectional analyzed baseline data from Biomarkers Study,...
Importance Mild Behavioral Impairment(MBI), characterized by neuropsychiatric symptoms(NPS) that precede cognitive decline, may reflect early neurodegenerative changes. Identifying structural brain changes associated with MBI could enhance risk stratification and intervention. Objective To investigate the association between symptoms cortical thinning as a marker of neurodegeneration in Southeast Asian cohort. Design, Setting, Participants This cross-sectional study analyzed baseline data...
Abstract Background The Test of Practical Judgement (TOP‐J) in its 9‐item (TOPJ9) and 15‐item (TOPJ15) versions (Rabin et el., 2007), validated for assessing practical judgement, encompasses day‐to‐day scenarios medical, financial, safety, social/ethical domains. This study seeks to evaluate utility distinguishing cognitively unimpaired (CU) individuals from those with Mild Cognitive Impairment (MCI) within a Southeast Asian population. investigation aims contribute insights into the...
Abstract Background Mild Behavioral Impairment (MBI) is the onset of sustained neuropsychiatric symptoms that are considered as a possible precursor to neurodegenerative conditions, especially dementia. The concept MBI recognizes behavioral changes may be an early sign brain due neurodegeneration. Very recent research has shown in might linked structure, including cortical thickness. Cortical thickness associated with various diseases, Alzheimer’s disease and other forms We examined...
Abstract Background Visual Cognitive Assessment Test(VCAT) is a visual‐based cognitive evaluation tool which can be administered to multilingual populations without translation. VCAT has shown effective in differentiating mild impairment(MCI) from cognitively normal and useful for diagnosing MCI AD(Kandiah et al., 2016). However, whether also between vascular non‐vascular remains explored. Method 604 non‐demented participants were recruited the community as part of Southeast Asian Biomarker...
Abstract Background Behavioural changes are among the first symptoms noticeable to person themselves as they begin experience cognitive decline. Blood‐based biomarkers could potentially be a less invasive and easily detectable biomarker for early identification of Alzheimer's disease dementia. However, contributions pathobiology blood trajectory prevalence in Asians requires further definition. We examined association between blood‐based markers(BBM) neuropsychiatric symptoms(NPS)...
Abstract Background Astrocyte reactivity marked by elevations in Glial Fibrillary Acidic Protein(GFAP), was found to increase Phosphorylated Tau181(pTau181) induced neurodegenerative effects Alzheimer’s Disease (Bellaver et al., 2023). Nevertheless, the effect of GFAP‐ pTau181 axis vascular/mixed dementias has yet be completely elucidated. In this study, we investigated GFAP‐pTau181 on cognition a Southeast Asian cohort having high burden cerebrovascular disease. Methods A cross‐sectional...
Abstract Background Factors contributing to cognitive decline in adults include vascular risk factors (hypertension, hyperlipidemia, diabetes), lower education, age, Apolipoprotein E4(ApoE4) and cerebral hypoperfusion. The interplay between aging processes disrupts hemodynamics, heightening the of impairment neurological disorders. Similarly, ApoE4 gene increases vascular‐related small vessel disease. interaction factors, perfusion carrier status on performance needs further exploration a...
Abstract Background The Visual Cognitive Assessment Test (VCAT) is a visual based, language neutral cognitive assessment validated across cultures and ethnicities, that allows for early diagnosis of impairment. VCAT assess domains cognition – Memory, Visuospatial function, attention, Executive function. Mild Behavioural Impairment Checklist (MBI‐C) was developed to five NPS Decreased motivation, emotional dysregulation, impulse control, social inappropriateness abnormal beliefs/perceptions...
Abstract Background Post Stroke Cognitive Impairment (PSCI) is seen in 40‐60% of patients with ischemic strokes. Response PSCI to structured cognitive rehabilitation not clearly understood. We evaluated baseline variables that predict response an eight‐week non‐pharmacological intervention among mild strokes and compared the responses acute stroke without chronic cerebrovascular disease (CVD). Method 139 survivors were recruited from a tertiary hospital Singapore. All underwent group...