A5075094434- Global Cancer Incidence and Screening
- Colorectal Cancer Screening and Detection
- BRCA gene mutations in cancer
- Health Systems, Economic Evaluations, Quality of Life
- Cancer Risks and Factors
- Nutrition, Genetics, and Disease
- Genetic Associations and Epidemiology
- Acute Ischemic Stroke Management
- Cervical Cancer and HPV Research
- Breast Cancer Treatment Studies
- Stroke Rehabilitation and Recovery
- Dementia and Cognitive Impairment Research
- Female Genital Mutilation/Cutting Issues
- Cancer survivorship and care
- Genital Health and Disease
National University of Singapore
2014-2022
National University Health System
2014-2022
Objectives This study aimed to quantify health-related quality of life (HRQoL) loss associated with first episode stroke by comparing patient-reported HRQoL before and after onset. The impact in local population was also evaluated the pre- post-stroke that general population. Methods survivors assessed EQ-5D-3L index score at recruitment, for recalled pre-stroke HRQoL, 3 12 month post-stroke. Change from self-reported 285 238 patients, respectively. Mean EQ each time point (baseline: 464...
Family history, and genetic non-genetic risk factors can stratify women according to their individual of developing breast cancer. The extent overlap between these predictors is not clear.
Routine mammography screening is currently the standard tool for finding cancers at an early stage, when treatment most successful. Current breast programmes are one-size-fits-all which all women above a certain age threshold encouraged to participate. However, cancer risk varies by individual. The BREAst Tailored HEr (BREATHE) study aims assess acceptability of comprehensive risk-based personalised in Singapore. Advancing beyond current age-based paradigm, BREATHE integrates both genetic...
Abstract Background Early detection of breast cancer (BC) through mammography screening (MAM) is known to reduce mortality. We examined the differential effect that has on BC characteristics and overall survival sociodemographic determinants MAM utilization in a multi-ethnic Asian population. Methods This study included 3739 patients from Singapore Breast Cancer Cohort (2010–2018). Self-reported were collected using structured questionnaire. Clinical data obtained medical records. Patients...
Health-related quality of life (HRQoL) is a key metric to understand the impact stroke from patients' perspective. Yet HRQoL not readily measured in clinical practice. This study aims investigate extent which outcomes during admission predict at 3 months and 1 year post-stroke.Stroke patients admitted five tertiary hospitals Singapore were assessed with Shah-modified Barthel Index (Shah-mBI), National Institute Health Stroke Scale (NIHSS), Modified Rankin (mRS), Mini-Mental State Examination...
This study aimed to evaluate the cost-effectiveness of a breast cancer screening programme that incorporates genetic testing using associated single nucleotide polymorphisms (SNPs), against current biennial mammogram-only aid in its implementation into Singapore.A Markov model was used compare costs and health outcomes programme, polygenic risk-tailored which can advise long-term strategy depending on individual's risk. The took perspective healthcare system, with time horizon 40 years,...
This article aims to provide a detailed description of the Singapore Breast Cancer Cohort (SGBCC), an ongoing multi-ethnic cohort established with overarching goal identify genetic markers for breast cancer risk, prognosis and treatment response, as well understand ethnic differences in disease risk outcome Asian setting. The comprises patients aged 21 years above from six public hospitals which diagnose treat nearly 76% cases Singapore. Self-reported data on sociodemographic lifestyle,...
Background Genital warts (GW) are a common sexually transmissible infection (STI) among young adults and associated with poor quality of life (QoL). We investigated the functional psychosocial effect GW on Singaporean patients evaluated for any variations in QoL between genders.Patients completed standard questionnaire containing Short Form-36 (SF-36) health survey Cuestionario Específico para Condiloma Acuminado cross-sectional survey. deficits were determined by comparing SF-36 scores...
Abstract BackgroundThis study aimed to evaluate the cost effectiveness of a breast cancer screening programme that incorporates genetic testing using associated single nucleotide polymorphisms (SNPs) in Singapore, against current biennial mammogram only programme.MethodsA Markov model was used compare costs and health outcomes programme, polygenic risk tailored advises long term depending risk. The took perspective healthcare system, with time horizon 40 years, following women from age 35...
Physical activity (PA) is known to reduce breast cancer (BC) risk and improve patient prognosis. However, the association between pre-diagnostic PA aggressiveness of BC unclear. We investigated associations PA, tumour characteristics, survival. This retrospective observational study included 7688 patients from Singapore Breast Cancer Cohort (2010−2016). information questionnaire intensity (light/moderate/vigorous) duration (<1 h/1−2 h/>2 h per week). A score (1−5) incorporating was...
e22500 Background: Early detection of breast cancer (BC) through mammography screening (MAM) is known to reduce mortality. We examined the differential effect that has on BC characteristics and overall survival sociodemographic determinants MAM utilisation in a multi-ethnic Asian population. Methods: This study included 3,739 patients from Singapore Breast Cancer Cohort (2010–2018). Self-reported socio-demographic were collected using structured questionnaire. Clinical data obtained medical...
Abstract Background Routine mammography screening is currently the standard tool for finding cancers at an early stage, when treatment most successful. Current breast programmes are one-size-fits-all which all women above a certain age threshold encouraged to participate. However, cancer risk varies by individual. The BREAst Tailored HEr (BREATHE) study aims assess acceptability of comprehensive risk-based personalised in Singapore. Methods/Design Advancing beyond current age-based paradigm,...