A5066673011- Global Cancer Incidence and Screening
- Colorectal Cancer Screening and Detection
- BRCA gene mutations in cancer
- Cervical Cancer and HPV Research
- Telomeres, Telomerase, and Senescence
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- AI in cancer detection
- Pluripotent Stem Cells Research
- Radiomics and Machine Learning in Medical Imaging
- Tissue Engineering and Regenerative Medicine
- T-cell and B-cell Immunology
National University of Singapore
2021-2025
National University Health System
2021-2022
Duke-NUS Medical School
2016
National Cancer Centre Singapore
2016
Routine mammography screening is currently the standard tool for finding cancers at an early stage, when treatment most successful. Current breast programmes are one-size-fits-all which all women above a certain age threshold encouraged to participate. However, cancer risk varies by individual. The BREAst Tailored HEr (BREATHE) study aims assess acceptability of comprehensive risk-based personalised in Singapore. Advancing beyond current age-based paradigm, BREATHE integrates both genetic...
<title>Abstract</title> <bold>Objective</bold> Biennial mammography screening is well-established for women aged 50 and above, but guidelines younger are less clear. Risk-based may provide with key information to make informed decisions about their breast cancer risk screening. This study examines how predicted (BC) shapes women’s perception confidence in prediction. <bold>Methods</bold> Women 35 59 years were recruited a prospective multi-centre cohort stratified into above-average,...
In most human somatic cells, the lack of telomerase activity results in progressive telomere shortening during each cell division. Eventually, DNA damage responses triggered by critically short telomeres induce an irreversible cycle arrest termed replicative senescence. However, cellular pluripotent stem cells to uncapping remain unknown. We generated knockout embryonic (ES) through gene targeting. Telomerase inactivation ES shortening. Telomere and neural progenitor induces rapid apoptosis...
Singapore launched a population-based organised mammography screening (MAM) programme in 2002. However, uptake is low. A better understanding of breast cancer (BC) risk factors has generated interest shifting from one-size-fits-all to risk-based approach. public acceptability the change lacking. Focus group discussions (FGD) were conducted with 54 women (median age 37.5 years) no BC history. Eight online sessions transcribed, coded, and thematically analysed. Additionally, we surveyed 993...
Abstract Objective Ethnic disparity persists despite equal access to health care in Singapore, with Malay-Muslim women having the lowest mammogram uptake rate and highest breast cancer mortality rate. We sought understand barriers facilitators for this community. Methods used a sequential mixed-methods design first explore reasons screening not cancer, then determine factors associated regular survey. maximum variation sampling semi-structured in-depth interviews select screeners...
Abstract Background Routine mammography screening is currently the standard tool for finding cancers at an early stage, when treatment most successful. Current breast programmes are one-size-fits-all which all women above a certain age threshold encouraged to participate. However, cancer risk varies by individual. The BREAst Tailored HEr (BREATHE) study aims assess acceptability of comprehensive risk-based personalised in Singapore. Methods/Design Advancing beyond current age-based paradigm,...