A5060485249- Ovarian cancer diagnosis and treatment
- Cancer Treatment and Pharmacology
- Cancer-related cognitive impairment studies
- Global Cancer Incidence and Screening
- Glioma Diagnosis and Treatment
- Cancer Risks and Factors
- BRCA gene mutations in cancer
- Renal cell carcinoma treatment
- Breast Cancer Treatment Studies
- Chemotherapy-related skin toxicity
- Cancer, Lipids, and Metabolism
- Intensive Care Unit Cognitive Disorders
- Inflammatory Biomarkers in Disease Prognosis
- Reproductive Biology and Fertility
- Genetic Associations and Epidemiology
- Colorectal Cancer Treatments and Studies
- Nutrition, Genetics, and Disease
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Screening and Detection
- Cancer survivorship and care
- Economic and Financial Impacts of Cancer
- Breast Lesions and Carcinomas
- Endometrial and Cervical Cancer Treatments
- Head and Neck Cancer Studies
- Health Systems, Economic Evaluations, Quality of Life
National Cancer Centre Singapore
2016-2025
Duke-NUS Medical School
2023
KK Women's and Children's Hospital
2020
SingHealth
2018
BC Cancer Agency
2015-2016
National Cancer Centre Japan
2012
Singapore General Hospital
2009
Existing evidence suggests that proinflammatory cytokines play an intermediary role in postchemotherapy cognitive impairment. This is one of the largest multicentered, cohort studies conducted Singapore to evaluate prevalence and biomarkers associated with impairment breast cancer patients.Chemotherapy-receiving patients (stages I-III) were recruited. Proinflammatory plasma concentrations [interleukin (IL)-1β, IL-2, IL-4, IL-6, IL-8, IL-10, granulocyte-macrophage colony-stimulating factor,...
Aim To define a predictive model for clinical behaviour of breast phyllodes tumours (PT) using histological parameters and surgical margin status. Methods Cases PT diagnosed in the Department Pathology Singapore General Hospital between January 1992 December 2010 were stratified into benign, borderline malignant grades based on combination (stromal atypia, hypercellularity, mitoses, overgrowth nature tumour borders). Surgical status was assessed. Clinical follow-up biostatistical modelling...
Introduction: Cutaneous melanoma is rare in Asia and the clinical presentation outcome of not well described Southeast Asia. In addition, it unclear if ethnic variations exist between various racial groups. The objective our study to present characteristics Singapore highlight ethnical differences Asians Caucasians living Singapore. Materials Methods: Data were retrospectively collected from 48 patients with histological confirmation who seen both National Skin Centre Cancer Results: Acral...
Comparison of patient health-related quality life (HRQOL) scores to a reference group is needed quantify the HRQOL impact disease or treatment. This study aimed establish population norms for 2 questionnaires-EuroQol 5-dimension 5-level questionnaire (EQ-5D-5L) and European Organisation Research Treatment Cancer Quality Life Questionnaire-Core Question-naire 30 (EORTC QLQ-C30) according age, sex ethnicity-and explore relationships between EQ-5D-5L, EORTC QLQ-C30 sociodemographic...
Hand-foot syndrome (HFS) is a common adverse effect of capecitabine treatment.To compare the incidence and time to onset grade 2 or greater HFS in patients receiving pyridoxine vs placebo identify biomarkers predictive HFS.This single-center, randomized double-blind, placebo-controlled phase 3 trial conducted at National Cancer Centre Singapore assessed whether oral could prevent higher 210 scheduled receive single-agent chemotherapy for breast, colorectal, other cancers.Patients were...
The most recent version of the European Society for Medical Oncology (ESMO) Clinical Practice Guidelines diagnosis, treatment and follow-up patients with endometrial cancer was published in 2022. It therefore decided, by both ESMO Indian Paediatric (ISMPO), to convene a virtual meeting July 2022 adapt guidelines take into account variations management Asia. These represent consensus opinion panel Asian experts representing oncological societies China (CSCO), India Indonesia (ISHMO), Japan...
Abstract Objective To assess large language models on their ability to accurately infer cancer disease response from free-text radiology reports. Materials and Methods We assembled 10 602 computed tomography reports patients seen at a single institution. All were classified into: no evidence of disease, partial response, stable or progressive disease. applied transformer models, bidirectional long short-term memory model, convolutional neural network conventional machine learning methods...
The Gail model (GM) is a risk-assessment used in individual estimation of the absolute risk invasive breast cancer, and has been applied to both clinical counselling cancer prevention studies. Although GM validated several Western studies, its applicability outside North America Europe remains uncertain. Singapore Breast Cancer Screening Project (SBCSP) nation-wide prospective trial screening mammography conducted between Oct 1994 Feb 1997, only such date. With long-term outcomes from this...
Background: There is conflicting evidence on the effect of chemotherapy and psychosocial distress perceived cognitive changes in cancer patients. Objective: To compare severity disturbance Asian breast patients receiving those not chemotherapy, identify clinical characteristics associated with disturbances. Methods: A cross-sectional, observational study was conducted at largest center Singapore. Breast completed Functional Assessment Cancer Therapy–Cognitive Function (FACT-Cog), European...
Family history, and genetic non-genetic risk factors can stratify women according to their individual of developing breast cancer. The extent overlap between these predictors is not clear.
5565 Background: The optimal treatment of recurrent ovarian clear cell carcinoma (rOCCC) remains unknown. Prior data suggests rOCCC is a chemo-resistant disease that may respond to programmed death protein 1 (PD-1)/programmed death-ligand (PD-L1) immune checkpoint inhibition (ICI). We aimed determine the efficacy D versus PCC in pts with rOCCC. Methods: In this multicentre, open-label, randomised phase 2 trial, 9 academic centres across Singapore, South Korea and Australia, enrolled...
Background: The majority of patients with hepatocellular carcinoma (HCC) are inoperable and results conventional chemotherapy dismal. Many end up no treatment options resort to alternative medicine. authors report the use Coriolus versicolor (CV) in advanced HCC poor liver function or who were unfit receive standard therapy. Methods: Fifteen eligible cases randomized 2:1 either CV placebo. primary endpoint was median time progression (TTP) between both arms. Secondary endpoints include...
<h3>Objectives</h3> The natural history and optimal management of serous tubal intraepithelial carcinoma (STIC), regardless <i>BRCA</i> status, is unknown. We report the follow-up findings a series incidental fallopian tube high-grade carcinomas (HGSCs) STICs identified in women at low risk for hereditary breast ovarian cancer (HBOC), undergoing surgery other indications. <h3>Materials Methods</h3> Cases STIC HGSC were from 2008. Patients with known <i>BRCA1</i> or <i>BRCA2</i> mutations,...
Statins, HMG-CoA reductase inhibitors, are commonly used cholesterol-lowering medications which also increasingly recognized to have anti-cancer properties for various cancers, including breast cancer. Most clinical evidence supports a protective effect of statin on reducing cancer recurrence, particularly in hormone-receptor positive cancers.This study seeks the impact use recurrence an Asian population.This is retrospective patients diagnosed with at National Cancer Centre and Singapore...
Incidence of breast cancer is rising rapidly in Asia. Some risk factors are modifiable. We examined the impact known factors, including body mass index (BMI), reproductive and hormonal density on incidence cancer, Singapore. The study population was a population-based prospective trial screening mammography - Singapore Breast Cancer Screening Project. Population attributable absolute risks due to various were calculated. Among 28,130 women, 474 women (1.7%) developed cancer. highest for...
Introduction: We conducted a randomized controlled trial evaluating the efficacy and tolerability of cryotherapy in preventing chemotherapy-induced peripheral neuropathy (CIPN) patients with early breast cancer receiving neo/adjuvant weekly paclitaxel. Methods: Patients were recruited from National Cancer Centre Singapore (1:1) to receive either or usual care. Cryotherapy was applied as frozen gloves socks on all extremities 15 min before paclitaxel until post-infusion every cycle. Efficacy...
Breast size as a risk factor of breast cancer has been studied extensively with inconclusive results. Here we examined the associations between and factors in 24,353 Asian women aged 50 to 64 years old enrolled nationwide mammography screening project conducted October 1994 February 1997. Information on demographic reproductive was obtained via questionnaire. ascertained bust line measured at study recruitment total area from mammogram. The average 91.2 cm 102.3 cm2, respectively. two...
Known prediction models for breast cancer can potentially by improved the addition of mammographic density and common genetic variants identified in genome-wide associations studies known to be associated with risk disease. We evaluated benefit including cumulative effect among women a Singapore population.We estimated using prospective cohort 24,161 aged 50 64 from available mammograms factors who were recruited between 1994 1997. measured medio-lateral oblique views both breasts. Each...
Background The optimal treatment of recurrent ovarian clear cell carcinoma remains unknown. There is increasing rationale to support the role immune checkpoint inhibitors targeting programmed death protein 1 (PD - 1)/programmed death-ligand (PD-L1) axis in carcinoma. Primary objective To evaluate efficacy durvalumab (MEDI-4736) compared with standard chemotherapy patients Study hypothesis Patients treated will have improved progression-free survival those physician’s choice. Trial design...