A5089500212- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Breast Implant and Reconstruction
- Global Cancer Incidence and Screening
- BRCA gene mutations in cancer
- Cancer and Skin Lesions
- Cancer Genomics and Diagnostics
- Cancer Risks and Factors
- HER2/EGFR in Cancer Research
- Genetic Associations and Epidemiology
- Milk Quality and Mastitis in Dairy Cows
- Advanced Breast Cancer Therapies
- Cancer Diagnosis and Treatment
- AI in cancer detection
- Nutrition, Genetics, and Disease
- Genetic factors in colorectal cancer
- Epigenetics and DNA Methylation
- Digital Imaging in Medicine
- Metastasis and carcinoma case studies
- Genomics and Rare Diseases
- Digital Radiography and Breast Imaging
- Meteorological Phenomena and Simulations
- Reconstructive Surgery and Microvascular Techniques
- Body Image and Dysmorphia Studies
- Anatomy and Medical Technology
KK Women's and Children's Hospital
2016-2025
Duke-NUS Medical School
2017-2025
SingHealth
2024
National University of Singapore
2014-2024
SingHealth Duke-NUS Academic Medical Centre
2021-2024
Cancer Research Malaysia
2024
Breast Center
2024
Public Health Ontario
2024
Singapore General Hospital
2014-2023
County Durham and Darlington NHS Foundation Trust
2021
Abstract Background HER2-low breast cancer (BC) is currently an area of active interest. This study evaluated the impact low expression HER2 on survival outcomes in HER2-negative non-metastatic (BC). Methods Patients with BC from 6 centres within Asian Breast Cancer Cooperative Group (ABCCG) ( n = 28,280) were analysed. was defined as immunohistochemistry (IHC) 1+ or 2+ and situ hybridization non-amplified (ISH−) HER2-zero IHC 0. Relapse-free (RFS) overall (OS) by hormone receptor status 0,...
Polygenic risk scores (PRS) have been shown to predict breast cancer in European women, but their utility Asian women is unclear. Here we evaluate the best performing PRSs for European-ancestry using data from 17,262 cases and 17,695 controls of ancestry 13 case-control studies, 10,255 Chinese a prospective cohort (413 incident cancers). Compared middle quintile distribution, highest 1% PRS distribution ~2.7-fold lowest has ~0.4-fold developing cancer. There no evidence heterogeneity...
MVA-BN is an orthopoxvirus vaccine that provides protection against both smallpox and mpox. In June 2022, Canada launched a publicly-funded vaccination campaign to offer at-risk populations including men who have sex with (MSM) workers. The safety of has not been assessed in this context. To address this, the Canadian National Vaccine Safety Network (CANVAS) conducted prospective surveillance during public health campaigns Toronto, Ontario Vancouver, British Columbia. Vaccinated participants...
Introduction: Nipple sparing mastectomy is oncologically safe and has a good cosmetic outcome. However, nipple was conventionally performed with reconstruction. Minimal scar (MSM) novel technique which could allow women, non-ptotic breasts, who do not want reconstruction, to conserve their areolar complex (NAC) avoid the transverse associated modified radical mastectomy. This first study on outcomes of MSM. Methods: MSM complications risk factors, recurrence rates were assessed. As...
Family history, and genetic non-genetic risk factors can stratify women according to their individual of developing breast cancer. The extent overlap between these predictors is not clear.
Abstract Purpose Removal of clipped nodes can improve sentinel node biopsy accuracy in breast cancer patients post neoadjuvant chemotherapy (NACT). However, the current methods localization have limitations. We evaluated feasibility a novel and removal technique by preoperative skin marking Skin Mark Axillary Technique (SMART), with secondary aim assessing ultrasound visibility various clips axillary after NACT. Methods Invasive histologically metastatic nodes, going for NACT, ≤3...
Abstract Background Early detection of breast cancer (BC) through mammography screening (MAM) is known to reduce mortality. We examined the differential effect that has on BC characteristics and overall survival sociodemographic determinants MAM utilization in a multi-ethnic Asian population. Methods This study included 3739 patients from Singapore Breast Cancer Cohort (2010–2018). Self-reported were collected using structured questionnaire. Clinical data obtained medical records. Patients...
Abstract Objective Reluctance to share hereditary cancer syndrome genetic test results with family is reported among Asian patients. This study aims explore patient factors influencing result sharing family, improve overall testing uptake. Methods Participants were women a personal/family history of breast and/or ovarian who received positive, negative, or variant uncertain significance result. In‐depth interviews conducted theme saturation facilitators and barriers for family. Grounded...
Removal of sonographically abnormal (up to 3) metastatic clipped nodes, without sentinel lymph node biopsy, could accurately predict axillary status in breast cancer patients receiving neoadjuvant chemotherapy. ypT and the first were statistically significant factors for nodal pathologic complete response. This novel approach requires validation larger studies.In who have node-positive cancer, chemotherapy result response (pCR) avoid an dissection (ALND). Axillary staging, such cases, can be...
BackgroundClinical management of Asian BRCA1 and BRCA2 pathogenic variants (PV) carriers remains challenging due to imprecise age-specific breast (BC) ovarian cancer (OC) risks estimates. We aimed refine these estimates using six multi-ethnic studies in Asia.MethodsData were collected on 271 301 families from Malaysia Singapore, ascertained through population/hospital-based case-series (88%) genetic clinics (12%). Age-specific estimated a modified segregation analysis method, adjusted for...
Li-Ping Wang, Li-Hua Yao, Dan Geok Hoon Lim, Mohammed Yahia Almaghrabi, Hua Shen, Xiao Yuan, Shan-Shan Liang
To assess the association of a polygenic risk score (PRS) for functional genetic variants with developing breast cancer.
Objectives To determine the waiting time for administration of analgesia to patients presenting emergency department (ED) with traumatic pain, and how severity pain affects patient's perception treatment they receive. Methods Consecutive aged 18–65 years ED during 2-week study period complaint secondary trauma were prospectively recruited. The numeric rating scale (NRS) was used indicate level experienced by patients. They interviewed using a structured questionnaire chart review also done...
PURPOSE: The initial staging CT scan for patients with colorectal cancer may reveal small, “indeterminate” hepatic lesions. significance of these lesions is often unknown at the time diagnosis. Surveillance recommended because they have an impact on subsequent management patients. This study was designed to determine prevalence and small (<1 cm scan), indeterminate liver detected preoperatively in whether further surveillance imaging required. METHODS: Data were collected retrospectively,...
There is no specific treatment for dengue-associated fulminant liver failure. We report a child with failure who was treated successfully intravenous N-acetylcysteine. A 6-year-old boy diagnosed After administration of N-acetylcysteine, rapid decrease in transaminases and normalization coagulation profile observed followed by clinical improvement favourable outcome despite factors associated poor prognosis. The use N-acetylcysteine safe efficient the failure, especially centres when...