A5002984939- Breast Lesions and Carcinomas
- Breast Cancer Treatment Studies
- Cancer and Skin Lesions
- HER2/EGFR in Cancer Research
- Salivary Gland Tumors Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Monoclonal and Polyclonal Antibodies Research
- Advanced Breast Cancer Therapies
- Cancer Treatment and Pharmacology
- Colorectal and Anal Carcinomas
- Urologic and reproductive health conditions
- Soft tissue tumor case studies
- Ovarian cancer diagnosis and treatment
- Uterine Myomas and Treatments
- Breast Implant and Reconstruction
- Cancer-related Molecular Pathways
- Endometrial and Cervical Cancer Treatments
- Cancer Genomics and Diagnostics
- Cell Adhesion Molecules Research
- Gynecological conditions and treatments
- BRCA gene mutations in cancer
- Cancer Risks and Factors
- Medical Imaging Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- AI in cancer detection
KK Women's and Children's Hospital
2016-2025
Singapore General Hospital
2019
Imperial College Healthcare NHS Trust
2009-2015
Boston Children's Hospital
2014
Imperial College London
2009-2013
Charing Cross Hospital
2012-2013
The London College
2009-2013
Hammersmith Hospital
2009-2010
Effective anticancer therapy induces tumor cell death through apoptosis. Noninvasive monitoring of apoptosis during may provide predictive outcome information and help tailor treatment. A caspase-3–specific imaging radiotracer, <sup>18</sup>F-(<i>S</i>)-1-((1-(2-fluoroethyl)-1H-[1,2,3]-triazol-4-yl)methyl)-5-(2(2,4-difluorophenoxymethyl)-pyrrolidine-1-sulfonyl)isatin (<sup>18</sup>F-ICMT-11), has been developed for use in PET studies. We report the safety, biodistribution, internal radiation...
Fibroepithelial lesions (FELs) are a heterogeneous group of tumours comprising fibroadenomas (FAs) and phyllodes (PTs). Here we used 16-gene panel that was previously discovered to be implicated in pathogenesis progression, characterise large international cohort FELs via targeted sequencing. The study comprised 303 (38%) FAs 493 (62%) PTs which were contributed by the International Consortium. There 659 (83%) Asian 109 (14%) non-Asian FELs, while ethnicity rest unknown. Genetic aberrations...
Abstract Purpose Removal of clipped nodes can improve sentinel node biopsy accuracy in breast cancer patients post neoadjuvant chemotherapy (NACT). However, the current methods localization have limitations. We evaluated feasibility a novel and removal technique by preoperative skin marking Skin Mark Axillary Technique (SMART), with secondary aim assessing ultrasound visibility various clips axillary after NACT. Methods Invasive histologically metastatic nodes, going for NACT, ≤3...
Our study aims to audit and evaluate the accuracy pitfalls of intraoperative evaluation frozen sentinel lymph nodes (IOE-FSLN) resection margins (IOE-FSM) compared final findings in paraffin sections. A total 264 cases underwent evaluation, encompassing 688 (SLNs) 1186 surgical margins. Frozen section (FS) diagnoses were with corresponding permanent sections FS (PFS). Sensitivity, specificity, false-negative rate, false-positive concordance rates assessed. Cases discrepancies a detailed...
ABSTRACT The use of cryoablation for B3 fibroepithelial lesions (FELs) the breast has not been well‐documented. Cryoablation offers several advantages over surgery in treating masses, including avoidance general anesthesia, less invasiveness, shorter recovery, and greater cost‐effectiveness. This prospective study reported outcome a patient with FEL treated cryoablation. Post‐procedure, low pain scores, early return to work, good cosmesis without complications. mass also reduced size,...
Aims To validate the Singapore nomogram for outcome prediction in breast phyllodes tumours a large cohort of Singaporean patients, as previous validation studies were conducted on small numbers patients. We also investigate association fibroadenomas and within subset our cohort. Methods Histological parameters, surgical margin status clinical follow-up data 259 women diagnosed with analysed. Patients concurrent malignant or premalignant disease excluded from to minimise confounding...
Removal of sonographically abnormal (up to 3) metastatic clipped nodes, without sentinel lymph node biopsy, could accurately predict axillary status in breast cancer patients receiving neoadjuvant chemotherapy. ypT and the first were statistically significant factors for nodal pathologic complete response. This novel approach requires validation larger studies.In who have node-positive cancer, chemotherapy result response (pCR) avoid an dissection (ALND). Axillary staging, such cases, can be...
Malignant transformation results in overexpression of choline-kinase (CHK) and altered choline metabolism, which is potentially detectable by immunohistochemistry (IHC). We investigated the utility CHK-alpha (CHKA) IHC as a complement to current diagnostic investigation prostate cancer analysing expression patterns normal (no evidence malignancy) malignant human tissue samples.
Malignant adenomyoepithelioma of the breast is a rare tumour with around 30 cases reported in literature. Metastases associated these tumours are usually haematogenous. Axillary lymph node metastases thought to be unusual, and it has been recently suggested that axillary dissection not indicated unless clinically palpable. We here present case 63-year-old woman, who developed malignant metastasis, included epithelial myoepithelial elements, spite absence enlarged nodes. suggest histological...
This is a case report of 51 year old male who was found to have an incidental left sided non-functioning adrenal mass on routine medical examination and which confirmed by CT MRI scans. A laparoscopic adrenalectomy done. On gross the tumour solitary well circumscribed solid-cystic with homogenous pinkish white cut surface. microscopic examination, composed variably sized tubules fenestrated channels lined bland cuboidal cells epithelioid cells. There focal extension capsule peri-adrenal fat....
Phyllodes tumours are uncommon fibroepithelial lesions that typically grow up to 4cm in size but 10cm known as giant phyllodes have been described. We present a case report of 20cm benign tumour and literature review.A 54 years old lady with an enlarging left breast mass measuring 6 months duration presented our outpatient clinic. She also had incidental right parotid lump. Core biopsy the returned cellular lesion. A mastectomy axillary lymph node sampling were done skin cover was obtained...
Abstract Overexpression of human epidermal growth factor receptor 2 (HER2) protein in breast cancers carries significant prognostic and therapeutic implications. Anti-HER2 blockade has shown to be a useful adjunct surgery treating HER2-positive tumours. Up till today, the HER2 immunohistochemistry (IHC) situ hybridisation (ISH) scoring algorithms are geared towards identifying cases. A recently published Phase III clinical trial (DESTINY-Breast04) demonstrated that an antibody–drug conjugate...
Trastuzumab-based chemotherapy has shown remarkable clinical benefits for patients with HER2-positive breast cancer. However, treatment regimens involving trastuzumab had little or no effect a subset of patients. Preliminary studies revealed WW-binding protein 2 (WBP2), an oncogenic transcription coactivator, to be coamplified HER2 in 36% cancers. We hypothesize that WBP2 regulates and correlates the response cancer trastuzumab.The coexpression tumors was validated using IHC. The role...
Diagnosing low-grade adenosquamous carcinoma (LGASC) presents significant challenges due to its subtle morphology, variable immunohistochemical expression, and resemblance benign lesions like radial scar complex sclerosing lesions.