A5040892560- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Sepsis Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Family and Patient Care in Intensive Care Units
- Childhood Cancer Survivors' Quality of Life
- Airway Management and Intubation Techniques
- Clinical Nutrition and Gastroenterology
- Intensive Care Unit Cognitive Disorders
- Infant Development and Preterm Care
- Mechanical Circulatory Support Devices
- Traumatic Brain Injury and Neurovascular Disturbances
- Tracheal and airway disorders
- Congenital Heart Disease Studies
- Neonatal and Maternal Infections
- Respiratory viral infections research
- Congenital Diaphragmatic Hernia Studies
- Pneumonia and Respiratory Infections
- Nutrition and Health in Aging
- Renal function and acid-base balance
- Emergency and Acute Care Studies
- Anesthesia and Sedative Agents
- Electrolyte and hormonal disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Neonatal and fetal brain pathology
KK Women's and Children's Hospital
2016-2025
Duke-NUS Medical School
2016-2025
SingHealth Duke-NUS Academic Medical Centre
2015-2025
SingHealth
2022-2025
National University of Singapore
2013-2024
King Saud bin Abdulaziz University for Health Sciences
2023
BioCruces Health research Institute
2023
Hospital de Cruces
2023
St. Jude Children's Research Hospital
2022-2023
Intensive Care Society
2015-2021
We sought to update our 2015 work in the Second Pediatric Acute Lung Injury Consensus Conference (PALICC-2) guidelines for diagnosis and management of pediatric acute respiratory distress syndrome (PARDS), considering new evidence topic areas that were not previously addressed.International consensus conference series involving 52 multidisciplinary international content experts PARDS four methodology from 15 countries, using methodology, implementation science.Not applicable.Patients with or...
Importance The use of hypertonic saline (HTS) vs mannitol in the control elevated intracranial pressure (ICP) secondary to neurotrauma is debated. Objective To compare mortality and functional outcomes treatment with 3% HTS 20% among children moderate severe traumatic brain injury (TBI) at risk ICP. Design, Setting, Participants This prospective, multicenter cohort study was conducted between June 1, 2018, December 31, 2022, 28 participating pediatric intensive care units Pediatric Acute...
Objective: Although more children are surviving critical illness, little is known about long-term physical impairment. This scoping review aims to critically appraise existing literature on functional outcome measurement tools, prevalence, and risk factors for impairments in pediatric care survivors. Data Sources: PubMed, Embase, Cumulative Index Nursing Allied Health Literature, using a combination of MeSH terms keywords (critical intensive care, outcomes/status). Study Selection: All human...
The impact of multiple tracheal intubation (TI) attempts on outcomes in critically ill children with acute respiratory failure is not known. objective our study to determine the association between number TI and severe desaturation (SpO2 < 70 %) adverse associated events (TIAEs). We performed an analysis a prospective multicenter database (National Emergency Airway Registry for Children: NEAR4KIDS). Primary exposure variable was trichotomized as one, two, or ≥3 attempts. Estimates were...
Abstract Background Fewer children than adults have been affected by the COVID-19 pandemic, and clinical manifestations are distinct from those of adults. Some particularly with acute or chronic co-morbidities likely to develop critical illness. Recently, a multisystem inflammatory syndrome (MIS-C) has described in some these patients requiring care pediatric ICU. Methods An international collaboration was formed review available evidence evidence-based guidelines for critically ill...
OBJECTIVES: In 2015, the Pediatric Acute Lung Injury Consensus Conference (PALICC) provided first pediatric-specific definitions for acute respiratory distress syndrome (pediatric [PARDS]). These have since been operationalized in cohort and interventional PARDS studies. As substantial data accrued we an opportunity to assess construct validity utility of initial PALICC definitions. Therefore, Second (PALICC-2) brought together multiple experts aimed identify summarize relevant evidence...
The true global burden of paediatric critical illness remains unknown. Studies on children with life-threatening conditions are hindered by the absence a common definition for acute (DEFCRIT) that outlines components and attributes does not depend local capacity to provide care. We present an evidence-informed consensus framework illness. DEFCRIT was developed following scoping review 29 studies key concepts identified interdisciplinary, international core expert panel (n=24). A modified...
Malnutrition is prevalent in critically ill children. We aim to describe nutrition received by children with acute respiratory distress syndrome (ARDS) and determine whether provision of adequate associated improved clinical outcomes.We studied characteristics outcomes 2 groups patients: (1) those who calories (defined as ≥80% predicted resting energy expenditure) (2) protein ≥1.5g/kg/d protein). Outcomes interest were mortality, ventilator-free days (VFDs), intensive care unit (ICU)-free...
Tracheal intubation in PICUs is a common procedure often associated with adverse events. The aim of this study to evaluate the association between immediate events such as tracheal or desaturation and ICU outcomes: length stay, duration mechanical ventilation, mortality. Prospective cohort 35 using multicenter quality improvement database (National Emergency Airway Registry for Children: NEAR4KIDS) from January 2013 June 2015. Desaturation defined Spo2 less than 80%. participating NEAR4KIDS....
Objectives: More children are surviving critical illness but at risk of residual or new health conditions. An evidence-informed and stakeholder-recommended core outcome set is lacking for pediatric care outcomes. Our objective was to create a multinational, multistakeholder-recommended inclusion in clinical research programs. Design: A two-round modified Delphi electronic survey conducted with 333 invited research, clinical, family/advocate stakeholders. Stakeholders completing the first...
OBJECTIVES: To describe the infrastructure and resources for pediatric emergency critical care delivery in resource-limited settings worldwide. DESIGN: Cross-sectional survey with items developed through literature review revised following piloting. SETTING: The electronic was disseminated internationally November 2019 via e-mail directories of intensive societies networks using social media. PATIENTS: Healthcare providers who self-identified as working settings. INTERVENTIONS: None....
Objectives: To identify a PICU Core Outcome Measurement Set (PICU COMS), set of measures that can be used to evaluate the COS) domains in patients and their families. Design: A modified Delphi consensus process. Setting: Four webinars attended by physicians nurses, pediatric surgeons, rehabilitation physicians, scientists with expertise clinical care or research ( n = 35). Attendees were from eight countries convened Pediatric Acute Lung Injury Sepsis Investigators Outcomes STudies after...
We describe the incidence, risk factors and outcomes of invasive candidiasis in infants >1500 g birth weight.
Acute respiratory distress syndrome (ARDS) represents the most severe form of acute lung injury. The aim our study is to describe epidemiology pediatric ARDS in Singapore and compare outcomes using following indices: PaO2/FiO2 ratio (P/F ratio), SpO2/FiO2 (S/F oxygenation index (OI), oxygen saturation (OSI).We examined medical records patients admitted Children's Intensive Care Unit KK Women's Hospital from 2009 2012. Those who fulfilled criteria for American-European Consensus Conference...