A5079814077- Sepsis Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Emergency and Acute Care Studies
- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Airway Management and Intubation Techniques
- Renal function and acid-base balance
- Cardiac, Anesthesia and Surgical Outcomes
- Traumatic Brain Injury and Neurovascular Disturbances
- Global Maternal and Child Health
- Trauma and Emergency Care Studies
- Congenital Heart Disease Studies
- Acute Kidney Injury Research
- Kawasaki Disease and Coronary Complications
- Nosocomial Infections in ICU
- Child and Adolescent Health
- Tracheal and airway disorders
- Patient Safety and Medication Errors
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Mechanical Circulatory Support Devices
- Metabolism and Genetic Disorders
- Pharmaceutical studies and practices
- Neonatal Health and Biochemistry
- Anesthesia and Sedative Agents
- Child Nutrition and Water Access
Aga Khan University Hospital
2016-2025
Aga Khan University
2016-2025
Aga Khan University
2020-2024
Aga Khan University Hospital Nairobi
2015-2024
Indus Hospital
2019-2023
Seattle Children's Hospital
2023
Boston Children's Hospital
2023
University of Babylon
2019
The true global burden of paediatric critical illness remains unknown. Studies on children with life-threatening conditions are hindered by the absence a common definition for acute (DEFCRIT) that outlines components and attributes does not depend local capacity to provide care. We present an evidence-informed consensus framework illness. DEFCRIT was developed following scoping review 29 studies key concepts identified interdisciplinary, international core expert panel (n=24). A modified...
Objectives: Extubation failure (EF) in neonates recovering from congenital cardiac surgery is associated with morbidity and mortality. Adding continuous physiologic monitoring data risk analytics algorithms to clinical factors has the potential assist clinicians identifying those at high for EF. We aimed evaluate association of two evaluating probability inadequate delivery oxygen index (ID o 2 ) ventilation carbon dioxide (IV co EF receiving mechanical (MV) after surgery. A secondary aim...
There is a scarcity of data regarding coronavirus disease 2019 (COVID-19) infection in children from southeast and south Asia. This study aims to identify risk factors for severe COVID-19 among the region. an observational with hospitals contributing Pediatric Acute Critical Care Registry Laboratory-confirmed cases were included this registry. The primary outcome was severity as defined by World Health Organization (WHO) (mild, moderate, severe, or critical). Epidemiology, clinical...
To develop a tele-intensive care service providing peer-to-peer teleconsultation for physicians in remote and resource-constrained health-care settings treatment of critically ill patients, to evaluate the outcomes service. The Aga Khan University started coronavirus disease 2019 (COVID-19) unit 2020. A central command centre used two-way audiovisual technology connect experienced intensive specialists clinical teams hospital settings. service, always available, messaging applications...
To determine clinical, laboratory features and outcomes of Multisystem Inflammatory Syndrome in children (MIS-C) its comparison with historic Kawasaki Disease (KD) Viral Myocarditis (VM) cohorts.All (1 month- 18 years) who fulfilled the World Health Organization criteria MIS-C presenting to two tertiary care centers Karachi from May 2020 till August 31st were included. KD VM admitted one study last five years prior this pandemic, was compared MIS-C.Thirty median age 24 (interquartile range...
Background: Pediatric Intensive Care Unit (PICU) patients are often prescribed antibiotics with a low threshold in comparison to elsewhere.Irrational use can lead rapid emergence of drug resistance, so surveillance their is important.Objectives: To evaluate the relation bacteriological findings PICU Tertiary Hospital.Methods: Retrospective review medical records all children (age 1 month-16 years) admitted our closed multidisciplinary-cardiothoracic from January June 2013 was performed,...
The use of antibiotics in paediatric intensive care units (PICU) is very high (ranging from 67% to 97%) due several reasons including incidence community-acquired sepsis, healthcare-associated infections or as a postoperative prophylaxis.1 This antibiotic leads problems development resistance, drug toxicity and interactions.2 Infectious Diseases Society America for Healthcare Epidemiology has initiated stewardship programme (ASP) better delivery hospitalised patients 2007 updated April 2016,...
We aimed to explore the epidemiological, clinical, and phenotypic parameters of pediatric patients hospitalized with COVID-19 in Pakistan.This longitudinal cohort study was conducted five tertiary care hospitals Pakistan from March 2020 December 2021. Data on various epidemiological clinical variables were collected using Case Report Forms (CRFs) adapted WHO data platform at baseline monthly follow-ups for 3 months.A total 1090 children included. The median age 5 years (Interquartile range...
To describe the spectrum of complications Diabetic Ketoacidosis (DKA) observed in children admitted with severe DKA.Retrospective review medical records all diagnosis DKA Pediatric Intensive Care Unit (PICU) Aga Khan University Hospital, from January 2010 to December 2015 was done. Data collected on a structured proforma and descriptive statistics were applied.Total 37 complicated (1.9% total PICU admission 1.8% 3.4% 2015). Mean age study population 8.1±4.6 years 70% females (26/37). Prism...
To evaluate nationwide pediatric critical care facilities and resources in Pakistan.Cross-sectional observational study.Accredited training Pakistan.None.None.A survey was conducted using the Partners Health 4S (space, staff, stuff, systems) framework, via email or telephone correspondence. We used a scoring system which each item our checklist given score of 1, if available. Total scores were added up for component. Additionally, we stratified analyzed data between public private healthcare...
Abstract Background The healthcare system is highly complex, and adverse events often result from a combination of human factors failures, especially in crisis situations. Crisis resource management skills are crucial to optimize team performance patient outcomes such Simulation-based training offers promising approach developing controlled realistic environment. Methods This study employed mixed-methods (quantitative-qualitative) design aimed assess the effectiveness simulation-based...
Intracerebral hemorrhage (ICH) in children is a rare but disabling disease that accounts for almost half cases of stroke. We report our experience ICH children. Retrospective review medical records (1 month-16 years) admitted Pediatric Intensive Care Unit between January 2007 and December 2014 was done. Data collected included age, gender, presentation, examination findings, neuroimaging done (CT, MRI, angiography) management (conservative/intervention), outcome. Results are presented as...
To evaluate the clinical and prognostic utility of procalcitonin (PCT), C-reactive protein (CRP), lactic acid in children admitted to Pediatric Intensive Care Unit (PICU) a university teaching hospital.Medical records (1 month-16 years) tested for serum PCT at time admission PICU our hospital from July 1, 2013, January 15, 2015, were reviewed. Within 24 h admission, Risk Mortality Score, blood cultures, white cell count, neutrophil counts, CRP, plasma acid, noted. Patient outcome was...
The burden of pediatric critical illness and resource utilization by children with in limited settings (RLS) are largely unknown. Without specific data that captures key aspects illness, disease presentation, for populations RLS, development a contextual framework appropriate, evidence-based interventions to guide allocation but available resources is challenging. We present this methods paper which describes our efforts determine the prevalence, etiology, hospital outcomes, associated...
Tracheal stenosis is a known complication following intubation. However, owing to its delayed presentation and symptoms of progressive wheezing respiratory difficulty, it often misdiagnosed as asthma. We present the case 10-year-old Asian boy who presented with cough, wheezing, dyspnea. He was severe, uncontrolled asthma failure, remaining unresponsive initial management. During his current admission, he had difficult intubation, necessitating an emergency tracheostomy. Further subsequent...
Acute necrotizing encephalopathy of childhood (ANEC) is a rare condition mainly affecting children with distinct clinico-radiologic pattern. Initially thought to be secondary respiratory viral infections, there have been more insights the pathogenesis ANEC including genetics. We present case girl who developed this classical findings severe dengue infection and could not survive. report aim raise awareness about fatal complication as has become global health-care problem.
<b>Objectives:</b> To determine the frequency and immediate outcome of acute neurologic complications (ANCs) in children undergoing congenital heart surgery (CHS). <b>Materials Methods:</b> Inthis retrospective study, all patients CHS at our hospital from January 2007 to June 2016 were included. Patients followed up for development seizures, altered level consciousness (ALOC), abnormal movements, stroke. Results are presented as mean with standard deviation percentages. <b>Results:</b> Of...
Central venous catheter (CVC) placement in children resource-limited settings (RLSs) can be a difficult task. Timely administration of vasopressor medications (VMs) through peripheral intravenous line (PIV) help overcome this limitation. We aim to determine the safety PIVs admitted pediatric intensive care unit (PICU) RLS.Prospective observational study. Setting. An eight-bedded PICU tertiary hospital. Patients. Children aged 1 month 18 years PICU. Intervention. None. Measurements and Main...
Background: Thalassemia is one of the most common inherited diseases; it an impairment hemoglobin production, in which there partial or complete failure synthesis globin chain. Hepatitis B and hepatitis C had emerged as a major cause end-stage liver disease. Both viruses are transfusion-transmitted Objective: The objective study to assess prevalence thalassemic patients its relation with type thalassemia, blood transfusion, spleen status. Material Methods: A cross-sectional was conducted on...