J. Wesley Diddle
A5048082088- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Sepsis Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Cardiac, Anesthesia and Surgical Outcomes
- Congenital Heart Disease Studies
- Respiratory Support and Mechanisms
- Emergency and Acute Care Studies
- Disaster Response and Management
- Acute Kidney Injury Research
- Neonatal and fetal brain pathology
- Simulation-Based Education in Healthcare
- Trauma Management and Diagnosis
- Neonatal Respiratory Health Research
- Ultrasound in Clinical Applications
- Cardiac Structural Anomalies and Repair
- Viral Infections and Vectors
- Renal and Vascular Pathologies
- Injury Epidemiology and Prevention
- Aortic Disease and Treatment Approaches
- Airway Management and Intubation Techniques
- Heart Failure Treatment and Management
- Intensive Care Unit Cognitive Disorders
Children's Hospital of Philadelphia
2023-2025
Children's National
2018-2025
University of Pennsylvania
2023-2025
Philadelphia University
2023-2025
George Washington University
2018-2024
Children's Hospital Colorado
2022
University of Colorado Denver
2022
Society of Thoracic Surgeons
2022
Children's Hospital of Pittsburgh
2015
University of Pittsburgh Medical Center
2015
Objectives: To characterize survival outcomes for adult patients with acute myocarditis supported extracorporeal membrane oxygenation and identify risk factors in-hospital mortality. Design: Retrospective review of Extracorporeal Life Support Organization registry database. Setting: Data reported to by 230 centers. Patients: Patients 16 years old or older during 1995 2011. Interventions: None. Measurements Main Results: There were 150 separate runs 147 a diagnosis in the database from...
Approximately 40% of children who experience an in-hospital cardiac arrest survive to hospital discharge. Achieving threshold intra-arrest diastolic blood pressure (BP) targets during cardiopulmonary resuscitation (CPR) and systolic BP after the return circulation may be associated with improved outcomes.To evaluate effectiveness a bundled intervention comprising physiologically focused CPR training at point care structured clinical event debriefings.A parallel, hybrid stepped-wedge, cluster...
Objectives: Extubation failure (EF) in neonates recovering from congenital cardiac surgery is associated with morbidity and mortality. Adding continuous physiologic monitoring data risk analytics algorithms to clinical factors has the potential assist clinicians identifying those at high for EF. We aimed evaluate association of two evaluating probability inadequate delivery oxygen index (ID o 2 ) ventilation carbon dioxide (IV co EF receiving mechanical (MV) after surgery. A secondary aim...
Families and clinicians have limited validated tools available to assist in estimating long-term outcomes early after pediatric cardiac arrest. Blood-based brain-specific biomarkers may be helpful aid outcome assessment. To analyze the association of blood-based brain injury biomarker concentrations with 1 year The Personalizing Outcomes After Child Cardiac Arrest multicenter prospective cohort study was conducted intensive care units at 14 academic referral centers US between May 16, 2017,...
OBJECTIVES: Arterial diastolic blood pressure (DBP) greater than 25 mm Hg in infants and 30 children 1 year old during cardiopulmonary resuscitation (CPR) was associated with survival to hospital discharge one prospective study. We sought validate these potential hemodynamic targets a larger multicenter cohort. DESIGN: Prospective observational SETTING: Eighteen PICUs the ICU-RESUScitation trial from October 2016 March 2020. PATIENTS: Children less or equal 18 years CPR seconds invasive (BP)...
Abstract Background Epinephrine is provided during cardiopulmonary resuscitation (CPR) to increase systemic vascular resistance and generate higher diastolic blood pressure (DBP) improve coronary perfusion attain return of spontaneous circulation (ROSC). The DBP response epinephrine pediatric CPR its association with outcomes have not been well described. Thus, the objective this study was measure between change in after administration ROSC. Methods This a prospective multicenter children...
To evaluate associations between sodium bicarbonate use and outcomes during pediatric in-hospital cardiac arrest (p-IHCA).Prespecified secondary analysis of a prospective, multicenter cluster randomized interventional trial.Eighteen participating ICUs the ICU-RESUScitation Project (NCT02837497).Children less than or equal to 18 years old greater 37 weeks post conceptual age who received chest compressions any duration from October 2016 March 2021.None.Child event characteristics, prearrest...
Assess the effect of a simulation "boot camp" on ability pediatric nurse practitioners to identify and treat low cardiac output state in postoperative patients with congenital heart disease. Additionally, assess practitioners' confidence satisfaction training.Prospective pre/post interventional pilot study.University center.Thirty acute care from 13 academic medical centers North America.We conducted an expert opinion survey guide curriculum development. The included didactic sessions, case...
Supported by laboratory and clinical investigations of adult cardiopulmonary arrest, resuscitation guidelines recommend monitoring end-tidal carbon dioxide (ETCO
Clinical observations and some studies suggest that dengue virus infection is more severe among children with better nutritional status. We examined the status of in El Salvador its relationship between this severity infection. Z-scores for weight-for-age, height-for-age, body mass index (BMI)-for-age fever (66), hemorrhagic (62), healthy controls (74) were compared. There no differences weight-for-age or BMI-for-age three groups. Children had a greater height-for-age than but significant...
OBJECTIVES: To assess associations between outcome and cardiopulmonary resuscitation (CPR) quality for in-hospital cardiac arrest (IHCA) in children with medical cardiac, surgical or noncardiac disease. DESIGN: Secondary analysis of a multicenter cluster randomized trial, the ICU-RESUScitation Project (NCT02837497, 2016–2021). SETTING: Eighteen PICUs. PATIENTS: Children less than equal to 18 years old greater 37 weeks postconceptual age receiving chest compressions (CC) any duration during...
Abstract Introduction Though early hypotension after pediatric in-hospital cardiac arrest (IHCA) is associated with inferior outcomes, ideal post-arrest blood pressure (BP) targets have not been established. We aimed to leverage prospectively collected BP data explore the association of thresholds outcomes. hypothesized that systolic and diastolic would be higher than currently recommended post-cardiopulmonary resuscitation rates survival hospital discharge. Methods performed a secondary...
Quality of cardiopulmonary resuscitation (CPR) is associated with survival, but recommended guidelines are often not met, and less than half the children an in-hospital arrest will survive to discharge. A single-center before-and-after study demonstrated that outcomes may be improved a novel training program in which all pediatric intensive care unit staff encouraged participate frequent CPR refresher regular, structured debriefings focused on patient-centric physiology. This ongoing trial...
OBJECTIVES: Data to support epinephrine dosing intervals during cardiopulmonary resuscitation (CPR) are conflicting. The objective of this study was evaluate the association between and outcomes. We hypothesized that less than 3 minutes would be associated with improved neurologic survival compared greater or equal minutes. DESIGN: This is a secondary analysis ICU-RESUScitation Project (NCT028374497), multicenter trial quality improvement bundle physiology-directed CPR training post-cardiac...
Importance Morbidity and mortality after pediatric cardiac arrest are chiefly due to hypoxic-ischemic brain injury. Brain features seen on magnetic resonance imaging (MRI) spectroscopy (MRS) may identify injury aid in outcome assessments. Objective To analyze the association of lesions T2-weighted MRI diffusion-weighted N-acetylaspartate (NAA) lactate concentrations MRS with 1-year outcomes arrest. Design, Setting, Participants This multicenter cohort study took place intensive care units at...