A5041390159- Cardiac Arrest and Resuscitation
- Congenital Heart Disease Studies
- Mechanical Circulatory Support Devices
- Trauma and Emergency Care Studies
- Respiratory Support and Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Neonatal and fetal brain pathology
- Hemodynamic Monitoring and Therapy
- Trauma Management and Diagnosis
- Sepsis Diagnosis and Treatment
- Traumatic Brain Injury Research
- Emergency and Acute Care Studies
- Anesthesia and Neurotoxicity Research
- Disaster Response and Management
- Neonatal Respiratory Health Research
- Aortic Disease and Treatment Approaches
- Cardiac Structural Anomalies and Repair
- Optical Imaging and Spectroscopy Techniques
- Pulmonary Hypertension Research and Treatments
- Injury Epidemiology and Prevention
- Antibiotics Pharmacokinetics and Efficacy
- Non-Invasive Vital Sign Monitoring
- Cardiovascular Issues in Pregnancy
- Cardiac, Anesthesia and Surgical Outcomes
- Intensive Care Unit Cognitive Disorders
Children's Hospital of Philadelphia
2016-2025
University of Pennsylvania
2016-2025
Philadelphia University
2015-2025
Coventry (United Kingdom)
2022
University of Southern California
2016
Children's Hospital of Los Angeles
2016
The University of Texas Health Science Center at Houston
2016
University of British Columbia
2016
Ideon Innovation (Sweden)
2015
Valve (United States)
2014
Neonatal congenital heart disease (CHD) is associated with altered cerebral hemodynamics and increased risk of brain injury. Two novel noninvasive techniques, magnetic resonance imaging (MRI) diffuse optical correlation spectroscopies (diffuse spectroscopy (DOS), (DCS)), were employed to quantify blood flow ( CBF) oxygen metabolism CMRO 2 ) 32 anesthetized CHD neonates at rest during hypercapnia. Cerebral venous saturation S v O CBF measured simultaneously MRI in the superior sagittal sinus,...
There are few data on the prevalence or outcome of bystander cardiopulmonary resuscitation (BCPR) in children 18 years and younger.To characterize BCPR pediatric out-of-hospital cardiac arrests (OHCAs).This analysis Cardiac Arrest Registry to Enhance Survival database investigated nontraumatic OHCAs younger from January 2013 through December 2015.Bystander CPR, which included conventional CPR compression-only CPR.Overall survival neurologically favorable survival, defined as a Cerebral...
Approximately 40% of children who experience an in-hospital cardiac arrest survive to hospital discharge. Achieving threshold intra-arrest diastolic blood pressure (BP) targets during cardiopulmonary resuscitation (CPR) and systolic BP after the return circulation may be associated with improved outcomes.To evaluate effectiveness a bundled intervention comprising physiologically focused CPR training at point care structured clinical event debriefings.A parallel, hybrid stepped-wedge, cluster...
We evaluated the relationship between clinical features and hypoxic-ischemic injury (HII) shown by diffusion-weighted MRI (DWI) in young children with head trauma, comparing inflicted trauma (IT) to accidental (AT). This single-center consecutive cohort study included age birth 36 months admitted for July 2001 December 2004 brain magnetic resonance imaging (MRI) obtained ≤1 week, identified from prospectively maintained registries of trauma. Clinical radiological data during hospital stay...
Objectives: During cardiopulmonary resuscitation, adequate coronary perfusion pressure is essential for establishing return of spontaneous circulation. Current American Heart Association guidelines recommend standardized interval administration epinephrine patients in cardiac arrest. The objective this study was to compare short-term survival using a hemodynamic directed resuscitation strategy versus chest compression depth-directed porcine model Design: Randomized interventional study....
Although current resuscitation guidelines are rescuer focused, the opportunity exists to develop patient-centered strategies that optimize hemodynamic response of individual in hopes improve survival.To determine if titrating cardiopulmonary (CPR) blood pressure would 24-hour survival compared with traditional CPR a porcine model asphyxia-associated ventricular fibrillation (VF).After 7 minutes asphyxia, followed by VF, 20 female 3-month-old swine randomly received either pressure-targeted...
Treatment algorithms for cardiac arrest are rescuer centric and vary little from patient to patient. The objective of this study was determine if cardiopulmonary resuscitation-targeted arterial blood pressure coronary perfusion rather than optimal guideline care would improve 24-hour survival in a porcine model ventricular fibrillation arrest.Preclinical animal laboratory using female 3-month-old swine.A randomized interventional study.After induction anesthesia 7 minutes untreated...
We aimed to determine the prevalence and risk factors for electrographic seizures in neonates children requiring extracorporeal membrane oxygenation support.Prospective quality improvement project.Quaternary care pediatric institution.Consistent with American Clinical Neurophysiology Society electroencephalographic monitoring recommendations, support underwent clinically indicated monitoring.We performed a 2-year study from July 2013 June 2015 evaluating seizure factors.Ninety-nine of 112...
OBJECTIVES: Arterial diastolic blood pressure (DBP) greater than 25 mm Hg in infants and 30 children 1 year old during cardiopulmonary resuscitation (CPR) was associated with survival to hospital discharge one prospective study. We sought validate these potential hemodynamic targets a larger multicenter cohort. DESIGN: Prospective observational SETTING: Eighteen PICUs the ICU-RESUScitation trial from October 2016 March 2020. PATIENTS: Children less or equal 18 years CPR seconds invasive (BP)...
Chylothorax is an uncommon complication of cardiothoracic surgery in children that traditionally treated with either conservative (diet modification, octreotide administration, and percutaneous drainage) or surgical (thoracic duct ligation, pleurodesis, pleuroperitoneal shunt) approaches. We report here the cases 2 (a 6-month-old a 1-month-old) postoperative chylous leaks who were successfully by thoracic embolization.
Although advances in cardiopulmonary resuscitation have improved survival from cardiac arrest (CA), neurologic injury persists and impaired mitochondrial bioenergetics may be critical for targeted neuroresuscitation. The authors sought to determine if excellent postresuscitation care good traditional rates result persistently disordered cerebral a porcine pediatric model of asphyxia-associated ventricular fibrillation CA.After 7 minutes asphyxia, followed by fibrillation, 5 female...
Abstract Background Epinephrine is provided during cardiopulmonary resuscitation (CPR) to increase systemic vascular resistance and generate higher diastolic blood pressure (DBP) improve coronary perfusion attain return of spontaneous circulation (ROSC). The DBP response epinephrine pediatric CPR its association with outcomes have not been well described. Thus, the objective this study was measure between change in after administration ROSC. Methods This a prospective multicenter children...
Out-of-hospital cardiac arrests (OHCA) increased in the adult population during COVID pandemic.1,2,3,4,5,6,7,8. We aimed to determine if OHCAs pediatric pandemic and whether exacerbated pre-existing racial socio-economic disparities.13,17,18,19,20. Utilizing data from 2015 2020 Cardiac Arrest Registry Enhance Survival (CARES) database, 13,513 were analyzed. Age categories included infants (0-<1 year), children (1-12 years) adolescents (13-18 years). This information on patient demographics,...