A5091312187- Optical Imaging and Spectroscopy Techniques
- Traumatic Brain Injury and Neurovascular Disturbances
- Non-Invasive Vital Sign Monitoring
- Hemodynamic Monitoring and Therapy
- Photoacoustic and Ultrasonic Imaging
- Advanced MRI Techniques and Applications
- Hemoglobinopathies and Related Disorders
- Spectroscopy Techniques in Biomedical and Chemical Research
- Neonatal and fetal brain pathology
- S100 Proteins and Annexins
- Congenital Heart Disease Studies
- Cardiovascular Health and Disease Prevention
- Intracranial Aneurysms: Treatment and Complications
- Infrared Thermography in Medicine
- Climate Change and Health Impacts
- MRI in cancer diagnosis
- Neuroinflammation and Neurodegeneration Mechanisms
- Aortic Disease and Treatment Approaches
- Cerebrovascular and Carotid Artery Diseases
- Functional Brain Connectivity Studies
- Cerebrospinal fluid and hydrocephalus
- Thermoregulation and physiological responses
- Photoreceptor and optogenetics research
- Neurosurgical Procedures and Complications
- Iron Metabolism and Disorders
The Wallace H. Coulter Department of Biomedical Engineering
2017-2025
Georgia Institute of Technology
2016-2025
Emory University
2017-2025
Children's Healthcare of Atlanta
2019-2025
Emory and Henry College
2016-2024
Parker Hannifin (United States)
2023
Drexel University
2022
The University of Melbourne
2020
Austin Health
2020
Peninsula Health
2020
Diffuse correlation spectroscopy (DCS) is an emerging optical modality used to measure cortical cerebral blood flow. This outlook presents a brief overview of the technology, summarizing advantages and limitations method, describing its recent applications animal, adult, infant cohorts. At last, paper highlights future where DCS may play pivotal role individualizing patient management enhancing our understanding neurovascular coupling, activation, brain development.
This report is the second part of a comprehensive two-part series aimed at reviewing an extensive and diverse toolkit novel methods to explore brain health function. While first focused on neurophotonic tools mostly applicable animal studies, here, we highlight optical spectroscopy imaging relevant noninvasive human studies. We outline current state-of-the-art technologies software advances, most recent impact these neuroscience clinical applications, identify areas where innovation needed,...
We employ a hybrid diffuse correlation spectroscopy (DCS) and near-infrared (NIRS) monitor for neonates with congenital heart disease (n=33). The NIRS-DCS device measured changes during hypercapnia of oxyhemoglobin, deoxyhemoglobin, total hemoglobin concentrations; cerebral blood flow (rCBF<sub>DCS</sub>); oxygen metabolism (rCMRO<sub>2</sub>). Concurrent measurements arterial spin-labeled magnetic resonance imaging (rCBF<sub>ASL-MRI</sub>, n=12) cross-validate rCBF<sub>DCS</sub> against...
Diffuse optics has proven useful for quantitative assessment of tissue oxy- and deoxyhaemoglobin concentrations and, more recently, measurement microvascular blood flow. In this paper, we focus on the flow monitoring technique: diffuse correlation spectroscopy (DCS). Representative clinical pre-clinical studies from our laboratory illustrate potential DCS. Validation DCS indices in human brain muscle is presented. Comparison with arterial spin-labelled MRI, xenon-CT Doppler ultrasound shows...
Neonatal congenital heart disease (CHD) is associated with altered cerebral hemodynamics and increased risk of brain injury. Two novel noninvasive techniques, magnetic resonance imaging (MRI) diffuse optical correlation spectroscopies (diffuse spectroscopy (DOS), (DCS)), were employed to quantify blood flow ( CBF) oxygen metabolism CMRO 2 ) 32 anesthetized CHD neonates at rest during hypercapnia. Cerebral venous saturation S v O CBF measured simultaneously MRI in the superior sagittal sinus,...
Four very low birth weight, premature infants were monitored during a 12 degrees postural elevation using diffuse correlation spectroscopy (DCS) to measure microvascular cerebral blood flow (CBF) and transcranial Doppler ultrasound (TCD) macrovascular velocity in the middle artery. DCS data correlated significantly with peak systolic, end diastolic, mean velocities measured by TCD (p(A) =0.036, 0.036, 0.047). Moreover, population averaged yielded no significant hemodynamic response this...
Near-infrared spectroscopy (NIRS) and diffuse correlation (DCS) are two optical technologies for brain imaging that sensitive to changes in hemoglobin concentrations blood flow, respectively. Measurements both modalities acquired on the scalp, therefore hemodynamic processes extracerebral vasculature confound interpretation of cortical signals. The sensitivity NIRS versus tissue contrast-to-noise ratio (CNR) cerebral responses have been well characterized, but same has not evaluated DCS....
Diffuse correlation spectroscopy (DCS) is a novel optical technique that appears to be an excellent tool for assessing cerebral blood flow in continuous and non-invasive manner at the bedside. We present new clinical validation of DCS methodology by demonstrating strong agreement between indices relative based on phase-encoded velocity mapping magnetic resonance imaging (VENC MRI) jugular veins superior vena cava. Data were acquired from 46 children with single ventricle cardiac lesions...
Neurophotonics was launched in 2014 coinciding with the launch of BRAIN Initiative focused on development technologies for advancement neuroscience. For last seven years, Neurophotonics' agenda has been well aligned this focus neurotechnologies featuring new optical methods and tools applicable to brain studies. While 2.0 is pivoting towards applications these novel quest understand brain, article we review an extensive diverse toolkit explore function that have emerged from related...
Microvascular cerebral blood flow exhibits pulsatility at the cardiac frequency that carries valuable information about cerebrovascular health. This study used diffuse correlation spectroscopy to quantify normative features of these waveforms in a cohort thirty healthy adults. We demonstrate they are sensitive changes vascular tone, as indicated by pronounced morphological with hypercapnia. Further, we observe significant sex-based differences waveform morphology, females exhibiting higher...
Congenital heart disease (CHD) patients are at risk for neurodevelopmental delay. The etiology of these delays is unclear, but abnormal prenatal cerebral maturation and postoperative hemodynamic instability likely play a role. A better understanding factors needed to improve outcome. In this study, we used bedside frequency-domain near infrared spectroscopy (FDNIRS) diffuse correlation (DCS) assess hemodynamics oxygen metabolism in neonates with single-ventricle (SV) CHD undergoing surgery...
Abstract Voxelotor is an inhibitor of sickle hemoglobin polymerization that used to treat cell disease. Although voxelotor has been shown improve anemia, the clinical benefit on brain remains be determined. This study quantified cerebral hemodynamic effects in children with anemia (SCA) using noninvasive diffuse optical spectroscopies. Specifically, frequency-domain near-infrared spectroscopy combined correlation were noninvasively assess regional oxygen extraction fraction (OEF), blood...
Investigating the cerebral physiology of healthy term newborns' brains is important for better understanding perinatal brain injuries, which most common etiologies are hypoxia and ischemia. Hence, blood flow oxygenation biomarkers health. In this study, we employed a hybrid diffuse optical system consisting correlation spectroscopy (DCS) frequency-domain near infrared (FDNIRS) to measure hemoglobin concentration, oxygen saturation, indices metabolism. We measured 30 infants assess...
Subarachnoid hemorrhage (SAH) is a devastating type of stroke, leading to high mortality and morbidity rates. Cerebral vasospasm delayed cerebral ischemia (DCI) are common complications following SAH that contribute significantly the poor outcomes observed in these patients. Intrathecal (IT) nicardipine delivered via an existing external ventricular drain off-label intervention has been shown be correlated with reduced DCI improved patient outcomes. The current study aims characterize...
Transcranial magnetic stimulation (TMS) modulates processing in the human brain and is therefore of interest as a treatment modality for neurologic conditions. During TMS administration, an electric current passing through coil on scalp creates rapidly varying field that induces currents cerebral cortex. The effects low-frequency (1 Hz), repetitive (rTMS ) motor cortex blood flow (CBF) tissue oxygenation seven healthy adults, during/after 20 min stimulation, reported. Noninvasive optical...
Repetitive concussions are associated with long-term cognitive dysfunction that can be attenuated by increasing the time intervals between concussions; however, biomarkers of safest rest interval injuries remain undefined. We hypothesize deranged cerebral blood flow (CBF) is a candidate biomarker for vulnerability to repetitive concussions. Using mouse model human concussion, we examined effect single and on cognition an index CBF (CBF i ) measured diffuse correlation spectroscopy. After...
Diffuse correlation spectroscopy (DCS) is a non-invasive optical technology for the assessment of an index cerebral blood flow (CBFi). Analytical methods that model head as three-layered medium (i.e., scalp, skull, brain) are becoming more commonly used to minimize contribution extracerebral layers measured DCS signal in adult studies. However, these models rely on priori knowledge layer properties and thicknesses. Errors values can lead errors estimation CBFi, although magnitude this...
One of the common complications non-traumatic subarachnoid hemorrhage (SAH) is delayed cerebral ischemia (DCI). Intrathecal (IT) administration nicardipine, a calcium channel blocker (CCB), upon detection large-artery vasospasm holds promise as treatment that reduces incidence DCI. In this observational study, we prospectively employed non-invasive optical modality called diffuse correlation spectroscopy (DCS) to quantify acute microvascular blood flow (CBF) response IT nicardipine (up 90...
Repetitive mild traumatic brain injury during adolescence can induce neurological dysfunction through undefined mechanisms. Interleukin-1 (IL-1) contributes to experimental adult diffuse and contusion TBI models, IL-1 antagonists have entered clinical trials for severe in adults; however, no such data exist adolescent TBI. We developed an mouse repetitive closed head (rCHI) model test the role of family members post-injury outcome. Compared one CHI, three daily injuries (3HD) produced acute...