A5084090691- Optical Imaging and Spectroscopy Techniques
- Microplastics and Plastic Pollution
- Turtle Biology and Conservation
- Hemodynamic Monitoring and Therapy
- Congenital Heart Disease Studies
- Non-Invasive Vital Sign Monitoring
- Recycling and Waste Management Techniques
- Traumatic Brain Injury and Neurovascular Disturbances
- Toxic Organic Pollutants Impact
- Neonatal and fetal brain pathology
- Effects and risks of endocrine disrupting chemicals
- Mercury impact and mitigation studies
- Air Quality and Health Impacts
- Photoacoustic and Ultrasonic Imaging
- Advanced MRI Techniques and Applications
- Environmental Toxicology and Ecotoxicology
- Anesthesia and Neurotoxicity Research
- Herpesvirus Infections and Treatments
- Cardiac Arrest and Resuscitation
- Physiological and biochemical adaptations
- Thermal Regulation in Medicine
- Avian ecology and behavior
- Per- and polyfluoroalkyl substances research
- Water Quality Monitoring and Analysis
- Aortic Disease and Treatment Approaches
Hawaii Pacific University
2018-2025
National Institute of Standards and Technology
2016-2025
University of Pennsylvania
2012-2025
Children's Hospital of Philadelphia
2016-2025
Norfolk and Norwich University Hospital
2024
National Institute of Standards
2024
Drexel University
2023
Duke University
2023
University of South Carolina Beaufort
2023
Janssen (United States)
2022
Microplastic pollution research has suffered from inadequate data and tools for spectral (Raman infrared) classification. Spectral matching often are not accurate microplastics identification cost-prohibitive. Lack of accuracy stems the diversity microplastic pollutants, which represented in libraries. Here, we propose a viable software solution: Open Specy. Specy is on web (www.openspecy.org) an R package. free allows users to view, process, identify, share their spectra community library....
The ubiquitous pollution of the environment with microplastics, a diverse suite contaminants, is growing concern for science and currently receives considerable public, political, academic attention. potential impact microplastics in has prompted great deal research recent years. Many methods have been developed to answer different questions about microplastic pollution, from sources, transport, fate environment, effects on humans wildlife. These are often insufficiently described, making...
This report is the second part of a comprehensive two-part series aimed at reviewing an extensive and diverse toolkit novel methods to explore brain health function. While first focused on neurophotonic tools mostly applicable animal studies, here, we highlight optical spectroscopy imaging relevant noninvasive human studies. We outline current state-of-the-art technologies software advances, most recent impact these neuroscience clinical applications, identify areas where innovation needed,...
Neonatal congenital heart disease (CHD) is associated with altered cerebral hemodynamics and increased risk of brain injury. Two novel noninvasive techniques, magnetic resonance imaging (MRI) diffuse optical correlation spectroscopies (diffuse spectroscopy (DOS), (DCS)), were employed to quantify blood flow ( CBF) oxygen metabolism CMRO 2 ) 32 anesthetized CHD neonates at rest during hypercapnia. Cerebral venous saturation S v O CBF measured simultaneously MRI in the superior sagittal sinus,...
Life for many of the world's marine fish begins at ocean surface. Ocean conditions dictate food availability and govern survivorship, yet little is known about habitat preferences larval during this highly vulnerable life-history stage. Here we show that surface slicks, a ubiquitous coastal convergence feature, are important nurseries from habitats ecosystem scales. Slicks had higher densities phytoplankton (1.7-fold), zooplankton (larval prey; 3.7-fold), (8.1-fold) than nearby ambient...
Polymeric differences of plastic debris were assessed across four compartments the Main Hawaiian Islands (sea surface, windward beaches, leeward and seafloor) to better describe sources fate. Plastic pieces (n = 4671) collected from 11 three sea surface tows, seafloor dives. Fourier transform infrared spectroscopy identified polymers 3551 pieces. Significant (p < 0.05) in concentration, types, polymer composition, weathering found among compartments. Windward beaches had 1-2 orders magnitude...
Diffuse correlation spectroscopy (DCS) is a novel optical technique that appears to be an excellent tool for assessing cerebral blood flow in continuous and non-invasive manner at the bedside. We present new clinical validation of DCS methodology by demonstrating strong agreement between indices relative based on phase-encoded velocity mapping magnetic resonance imaging (VENC MRI) jugular veins superior vena cava. Data were acquired from 46 children with single ventricle cardiac lesions...
Pelagic Pacific sea turtles eat relatively large quantities of plastic (median 5 g in gut). Using Fourier transform infrared spectroscopy, we identified the polymers ingested by 37 olive ridley, 9 green, and 4 loggerhead caught as bycatch Hawaii- American Samoa-based longline fisheries. Unidentifiable samples were analyzed using high-temperature size exclusion chromatography with multiple detectors and/or X-ray photoelectron spectroscopy. Regardless species differences dive depths foraging...
Background Infants with congenital heart disease (CHD) are at risk for white matter injury (WMI) before neonatal surgery. Better knowledge of the causes preoperative WMI may provide insights into interventions that improve neurodevelopmental outcomes in these patients. Methods and Results A prospective single-center study neonates CHD recorded data on primary cardiac diagnosis, maternal-fetal environment (MFE), delivery type, subject anthropometrics, care. Total maturation score were...
We study aging in a colloidal suspension consisting of micron-sized particles liquid. This system is made glassy by increasing the particle concentration. observe samples composed two sizes, with size ratio 1:2.1 and volume fraction 1:6, using fast laser scanning confocal microscopy. technique yields real-time, three-dimensional movies deep inside glass. Specifically, we look at how size, motion, structural organization relate to overall Particles move spatially heterogeneous cooperative...
In excess of 13,000 chemicals are added to plastics ('additives') improve performance, durability, and production plastic products. They categorized into numerous chemical classes including flame retardants, light stabilizers, antioxidants, plasticizers. While research on additives in the marine environment has increased over past decade, there is a lack methodological standardization. To direct future measurement additives, we compiled first-of-its-kind dataset literature assessing...
The chiA gene of Vibrio cholerae encodes a polypeptide which degrades chitin, homopolymer N-acetylglucosamine (GlcNAc) found in cell walls fungi and the integuments insects crustaceans. has coding capacity corresponding to 846 amino acids having predicted molecular mass 88.7 kDa. A 52-bp region with promoter activity was immediately upstream open reading frame. Insertional inactivation chromosomal copy confirmed that expression chitinase by V. required chiA. Fluorescent analogues were used...
ABSTRACT Varicella-zoster virus (VZV) codes for a protein serine kinase called ORF47; the herpes simplex (HSV) homolog is UL13. No recombinant alphaherpesvirus has been biologically active in vitro. We discovered that preservation of intrinsic activity VZV ORF47 required unusually stringent vitro conditions, including physiological concentrations polyamines. In this assay, phosphorylated two regulatory proteins: ORF62 (homolog HSV ICP4) and ORF63 ICP22). Of interest, also coprecipitated from...