A5090714588- Optical Imaging and Spectroscopy Techniques
- Photoacoustic and Ultrasonic Imaging
- Non-Invasive Vital Sign Monitoring
- Spectroscopy Techniques in Biomedical and Chemical Research
- Infrared Thermography in Medicine
- Thermoregulation and physiological responses
- Hemodynamic Monitoring and Therapy
- Traumatic Brain Injury and Neurovascular Disturbances
- Heart Rate Variability and Autonomic Control
- Photodynamic Therapy Research Studies
- Advanced Optical Sensing Technologies
- EEG and Brain-Computer Interfaces
- Advanced MRI Techniques and Applications
- Atomic and Subatomic Physics Research
- Calibration and Measurement Techniques
- Cardiovascular Health and Disease Prevention
- Optical Coherence Tomography Applications
- ECG Monitoring and Analysis
- Advanced Fluorescence Microscopy Techniques
- Photoreceptor and optogenetics research
- Advanced Measurement and Metrology Techniques
- Glaucoma and retinal disorders
- Tribology and Lubrication Engineering
- Advanced Sensor Technologies Research
- Cerebrovascular and Carotid Artery Diseases
Institute of Biocybernetics and Biomedical Engineering
2016-2025
Polish Academy of Sciences
2014-2025
Children's Hospital of Philadelphia
2022
University of Florence
2015
Bionics Institute
2010
Physikalisch-Technische Bundesanstalt
2001-2008
Medical University of Warsaw
2008
Klinikum Chemnitz
1999-2007
Humboldt-Universität zu Berlin
2005
Charité - Universitätsmedizin Berlin
2005
This report is the second part of a comprehensive two-part series aimed at reviewing an extensive and diverse toolkit novel methods to explore brain health function. While first focused on neurophotonic tools mostly applicable animal studies, here, we highlight optical spectroscopy imaging relevant noninvasive human studies. We outline current state-of-the-art technologies software advances, most recent impact these neuroscience clinical applications, identify areas where innovation needed,...
We report on multidistance time-resolved diffuse reflectance spectroscopy of the head a healthy adult after intravenous administration bolus indocyanine green. Intracerebral and extracerebral changes in absorption are deduced from moments (integral, mean time flight, variance) distributions times flight photons (DTOFs), recorded simultaneously at four different source-detector separations. calculate sensitivity factors converting depth-dependent into DTOFs by Monte Carlo simulations using...
A multi-center study has been set up to accurately characterize the optical properties of diffusive liquid phantoms based on Intralipid and India ink at near-infrared (NIR) wavelengths.Nine research laboratories from six countries adopting different measurement techniques, instrumental set-ups, data analysis methods determined their best relative uncertainties dilutions prepared with common samples two compounds.By exploiting a suitable statistical model, comprehensive reference values three...
Performance assessment of instruments devised for clinical applications is key importance validation and quality assurance. Two new protocols were developed applied to facilitate the design optimization time-domain optical brain imaging within European project nEUROPt. Here, we present “Basic Instrumental Performance” protocol direct measurement relevant characteristics. tests are discussed in detail. First, responsivity detection system a measure overall efficiency detect light emerging...
The nEUROPt protocol is one of two new protocols developed within the European project to characterize performances time-domain systems for optical imaging brain. It was applied in joint measurement campaigns compare various instruments and assess impact technical improvements. This addresses characteristic brain detect, localize, quantify absorption changes implemented with types inhomogeneous liquid phantoms based on Intralipid India ink well-defined properties. First, small black...
A novel method for the determination of optical properties tissue from time-domain measurements is presented. The data analysis based on evaluation first moment and second centralized moment, i.e., mean time flight variance measured distribution times (DTOF) photons injected by short (picosecond) laser pulses. Analytical expressions are derived calculation absorption reduced scattering coefficients these moments application diffusion theory infinite semi-infinite homogeneous media. proposed...
Abstract Monitoring of human tissue hemodynamics is invaluable in clinics as the proper blood flow regulates cellular-level metabolism. Time-domain diffuse correlation spectroscopy (TD-DCS) enables noninvasive measurements by analyzing temporal intensity fluctuations scattered light. With time-of-flight (TOF) resolution, TD-DCS should decompose at different sample depths. For example, head, it allows us to distinguish flows scalp, skull, or cortex. However, tissues are typically...
A time-resolved optical instrument allowing for noninvasive assessment of cerebral oxygenation is presented. The equipped with picosecond diode lasers, fast photodetectors, and time-correlated single photon counting electronics. This technology enables depth-resolved estimation changes in absorption and, consequence, hemoglobin concentrations the brain cortex. Changes oxyhemoglobin (HbO2) deoxyhemoglobin (Hb) can be evaluated selectively extra- intracerebral tissue compartments using moments...
We study fluorescence lifetime of indocyanine green (ICG) using femtosecond laser and sensitive detection based on time-correlated single-photon counting. A time-resolved multichannel spectral system is constructed applied for determination the ICG in different solvents. Emission properties water, milk, 1% intralipid solution are investigated. Fluorescence fluorophore concentrations (in a range 1.7-160 μM) dissolved solutions excited by pulses generated with use Ti:Sa tuned within 740-790...
The in-vivo optical properties of the human head are investigated in 600-1100 nm range on different subjects using continuous wave and time domain diffuse spectroscopy. work was performed collaboration with research groups techniques were applied to same subject. Data analysis carried out homogeneous layered models final results also confirmed by Monte Carlo simulations. depth sensitivity each technique related probed region cerebral tissue. This work, based validated instruments, is a...
The <i>Journal of Biomedical Optics</i> (JBO) is a Gold Open Access journal that publishes peer-reviewed papers on the use novel optical systems and techniques for improved health care biomedical research.
Time-domain measurements facilitate the elimination of influence extracerebral, systemic effects, a key problem in functional near-infrared spectroscopy (fNIRS) adult human brain. The analysis measured time-of-flight distributions photons often relies on moments or time windows. However, systematic and quantitative characterization performance these measurands is still lacking. Based perturbation simulations for small localized absorption changes, we compared spatial sensitivity profiles...
Significance: Multi-laboratory initiatives are essential in performance assessment and standardization—crucial for bringing biophotonics to mature clinical use—to establish protocols develop reference tissue phantoms that all will allow universal instrument comparison. Aim: The largest multi-laboratory comparison of near-infrared diffuse optics is presented, involving 28 instruments 12 institutions on a total eight experiments based three consolidated (BIP, MEDPHOT, NEUROPT) as implemented...
Near-infrared spectroscopy (NIRS) is an established technique for measuring tissue oxygen saturation (StO2), which of high clinical value. For tissues that have layered structures, it challenging but clinically relevant to obtain StO2 the different layers, e.g. brain and scalp. this aim, we present a new method data analysis time-domain NIRS (TD-NIRS) two-layered blood-lipid phantom. The enables accurate determination even large changes absorption coefficient (Δµa) in multiple layers. By...
We present an efficient Monte Carlo algorithm for simulation of time-resolved fluorescence in a layered turbid medium. It is based on the propagation excitation and photon bundles assumption equal reduced scattering coefficients at emission wavelengths. In addition to distributions times arrival photons detector, 3-D spatial generation probabilities were calculated. The was validated by comparison with analytical solution diffusion equation from homogeneous semi-infinite applied two-layered...
Recently, it was shown in measurements carried out on humans that time-resolved near-infrared reflectometry and fluorescence spectroscopy may allow for discrimination of information originating directly from the brain avoiding influence contaminating signals related to perfusion extracerebral tissues. We report continuation these studies, showing light can be detected noninvasively surface tissue at large interoptode distance. A multichannel optical monitoring system constructed diffuse...
Recent studies have shown that time-resolved optical measurements of the head can estimate changes in absorption coefficient with depth discrimination. Thus, tissue oxygenation, which are specific to intracranial tissues, be assessed using this advanced technique, and method allows us avoid influence extracerebral oxygenation on measured signals. We report results imaging was carried out during carotid endarterectomy. This surgery remains "gold standard" treatment for stenosis,...
Abstract Time-resolved near-infrared spectroscopy is an optical technique which can be applied in tissue oxygenation assessment. In the last decade this method extensively tested as a potential clinical tool for noninvasive human brain function monitoring and imaging. present paper we show construction of instrument allows for: (i) estimation changes using two-wavelength approach (ii) perfusion assessment with use single-wavelength reflectometry or fluorescence measurements combined...