A5103262521- Cardiac Arrest and Resuscitation
- Neonatal and fetal brain pathology
- Mechanical Circulatory Support Devices
- Disaster Response and Management
- Anesthesia and Neurotoxicity Research
- Non-Invasive Vital Sign Monitoring
- Thermal Regulation in Medicine
- Neuroscience of respiration and sleep
- Trauma and Emergency Care Studies
- Patient Safety and Medication Errors
- Emergency and Acute Care Studies
- Respiratory Support and Mechanisms
- Healthcare Technology and Patient Monitoring
- Simulation-Based Education in Healthcare
- Medical Malpractice and Liability Issues
- Sepsis Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Vitamin D Research Studies
- Clinical Reasoning and Diagnostic Skills
- Neonatal Respiratory Health Research
- Eicosanoids and Hypertension Pharmacology
- Cardiac Ischemia and Reperfusion
- Family and Patient Care in Intensive Care Units
- Airway Management and Intubation Techniques
- Delphi Technique in Research
Texas A&M University – Corpus Christi
2024
Children's Hospital of San Antonio
2021
Post Graduate Institute of Medical Education and Research
2021
Johns Hopkins University
2013-2018
Johns Hopkins Medicine
2013-2018
Children's Hospital of Philadelphia
2012-2018
University of Pennsylvania
2010-2018
University of Utah
2018
Kennedy Krieger Institute
2018
University of Michigan–Ann Arbor
2018
Therapeutic hypothermia is recommended for comatose adults after witnessed out-of-hospital cardiac arrest, but data about this intervention in children are limited.We conducted trial of two targeted temperature interventions at 38 children's hospitals involving who remained unconscious arrest. Within 6 hours the return circulation, patients were older than 2 days and younger 18 years age randomly assigned to therapeutic (target temperature, 33.0°C) or normothermia 36.8°C). The primary...
Objectives: During cardiopulmonary resuscitation, adequate coronary perfusion pressure is essential for establishing return of spontaneous circulation. Current American Heart Association guidelines recommend standardized interval administration epinephrine patients in cardiac arrest. The objective this study was to compare short-term survival using a hemodynamic directed resuscitation strategy versus chest compression depth-directed porcine model Design: Randomized interventional study....
Treatment algorithms for cardiac arrest are rescuer centric and vary little from patient to patient. The objective of this study was determine if cardiopulmonary resuscitation-targeted arterial blood pressure coronary perfusion rather than optimal guideline care would improve 24-hour survival in a porcine model ventricular fibrillation arrest.Preclinical animal laboratory using female 3-month-old swine.A randomized interventional study.After induction anesthesia 7 minutes untreated...
The consequences of therapeutic hypothermia for neonatal hypoxic–ischemic encephalopathy are poorly understood. Adverse effects from suboptimal rewarming could diminish neuroprotection hypothermia. Therefore, we tested whether is associated with apoptosis. Piglets underwent hypoxia–asphyxia followed by normothermic or hypothermic recovery at 2 hours. Hypothermic groups were divided into those no rewarming, 0.5 °C/hour, 4 °C/hour. Neurodegeneration 29 hours was assessed hematoxylin and eosin...
The severity of perinatal hypoxia-ischemia and the delay in initiating therapeutic hypothermia limit efficacy hypothermia. After neonatal piglets, arachidonic acid metabolite 20-hydroxyeicosatetraenoic (20-HETE) has been found to contribute oxidative stress at 3 h reoxygenation eventual neurodegeneration. We tested whether early administration a 20-HETE synthesis inhibitor after augments neuroprotection with 3-hour delayed In two hypothermic groups, whole body cooling from 38.5 34°C was...
Objective To determine if standardised chart review applied to records of patients discussed at a paediatric intensive care unit (PICU) morbidity and mortality conference (MMC) yields additional or different information regarding safety event occurrence characteristics. Design Retrospective record review. Setting Single tertiary referral PICU in Baltimore, Maryland, USA. Participants 96 the MMC over 14 months (November 2011–December 2012). Main outcome measures Safety events their...
To measure abdominal wall thickness to determine the depth at which renal vascular bed and mesenteric are located, appropriate site for placement of near-infrared spectroscopy probes accurate monitoring regional oxygen saturation index in children.Abdominal computerized tomography scans children were used ascertain location kidneys.Tertiary care children's hospital.Children 0-18 yrs age; n = 38.None.The main mass kidneys is located between vertebral levels T12 L2 on both sides. The left...
Head-tilt maneuver assists with achieving airway patency during resuscitation. However, the relationship between angle of head-tilt and has not been defined. Our objective was to define an optimal position for in neonates (age: 0–28 days) young infants 29 days–4 months). We performed a retrospective study head neck magnetic resonance imaging (MRI) patency. excluded those artificial or malformation. defined priori as occipito-ophisthion line ophisthion-C7 spinous process on sagittal MR...
To assess the knowledge, skills, and self-efficacy of health care participants completing a simulation-based blended learning training curriculum on managing maternal medical emergencies cardiac arrest (Obstetric Life Support).A formative assessment Obstetric Support was performed with prehospital cohort comprising emergency services professionals hospital-based who work primarily in hospital or urgent settings respond to emergencies. The consisted self-guided precourse an instructor-led...
Objective . We aimed to increase detection of pediatric cardiopulmonary resuscitation (CPR) events and collection physiologic performance data for use in quality improvement (QI) efforts. Materials Methods developed a workflow-driven surveillance system that leveraged organizational information technology systems trigger CPR analysis processes. characterized by notification source, type, location, year, compared it previous methods detection. Results From 1/1/2013 through 12/31/2015, there...
Background Simulation is used in critical care for skill development, formative assessment, and interprofessional team performance. Healthcare educators need to balance the relatively high cost deliver simulation education with potential impact on healthcare quality. It unclear how prioritize education, especially considering needs across adult pediatric populations. The objective of this study was topics developing simulation-based educational interventions. Methodology A modified Delphi...
Importance Management of maternal cardiac arrest (MCA) requires understanding the unique physiology pregnancy and modifications to life support. Health care professionals have historically demonstrated inadequate knowledge skills necessary treat MCA. Objective To evaluate effect Obstetric Life Support (OBLS) education on health professionals’ cognitive performance, skills, self-efficacy in managing Design, Setting, Participants In this single-masked randomized clinical trial, 46...
BACKGROUND Among in‐hospital cardiac arrest (IHCA) patients, the first rhythm documented on resuscitation records (FDR) is often used as a surrogate for etiology. Although FDR generally represents electrical activity at time of cardiopulmonary initiation, it may not be ideal to infer We hypothesized that present earlier—at code blue call—would frequently differ from FDR, because might represent later stage progressive process. OBJECTIVE To evaluate agreement between and telemetry call....
Introduction: In addition to traditional incident reporting, the MMC can augment ability surface AEs. Our objective is determine types, severity and preventability of AEs uncovered among patients discussed in a tertiary hospital PICU over specific time period compare these with reported for same cohort through reporting system, Patient Safety Network (PSN). Methods: Two independent reviewers conducted systematic retrospective record review 8 months (Nov2011-June2012). were identified...
The arachidonic acid metabolite 20-hydroxyeicosatetraenoic (20-HETE) has been found to contribute neurodegeneration after asphyxic cardiac arrest in neonatal piglets. Current therapy involving hypothermia is only partially effective, part, because initiation of often delayed. Therefore, an unmet need find a neuroprotective drug that can be safely given early resuscitation and provides additional protection compared delayed alone. Here, we tested whether administration the 20-HETE-synthesis...
Hemani, Malvi; Shah, Meehir; Kim, Barbara; Acharya, Soumyadipta; Allen, Robert; Bosemani, Thangamadhan; Huisman, Thierry; Bhalala, Utpal Author Information
Gutala, Divya1; Hemani, Malvi1; Chen, Steven1; Kitchen, Grant1; Allen, Robert1; Acharya, Soumyadipta1; Bosemani, Thangamadhan1; Bhalala, Utpal1 Author Information