Shubhada Hooli
A5090104827- Pneumonia and Respiratory Infections
- Emergency and Acute Care Studies
- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
- Global Maternal and Child Health
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Child Nutrition and Water Access
- Respiratory viral infections research
- Non-Invasive Vital Sign Monitoring
- Ultrasound in Clinical Applications
- Global Health and Surgery
- Hemodynamic Monitoring and Therapy
- Traumatic Brain Injury and Neurovascular Disturbances
- Healthcare Technology and Patient Monitoring
- Cardiac Arrest and Resuscitation
- Climate Change and Health Impacts
- Biomedical Ethics and Regulation
- Ethics and Legal Issues in Pediatric Healthcare
- Data-Driven Disease Surveillance
- Reproductive Health and Technologies
- Injury Epidemiology and Prevention
- Health Systems, Economic Evaluations, Quality of Life
- Demographic Trends and Gender Preferences
- Kawasaki Disease and Coronary Complications
- Sepsis Diagnosis and Treatment
Baylor College of Medicine
2016-2025
Texas Children's Hospital
2016-2024
Stanford University
2024
Johns Hopkins University
2023
British Columbia Children's Hospital
2022
University of British Columbia
2022
World Health Organization - Pakistan
2022
World Health Organization
2021-2022
Karolinska Institutet
2021
University College London
2021
Background Pneumonia is the leading infectious cause of under-5 mortality in sub-Saharan Africa. Clinical prediction tools may aide case classification, triage, and allocation hospital resources. We performed an external validation two published compared this to a locally developed tool identify children admitted with pneumonia at increased risk for in-hospital Malawi. Methods retrospectively analyzed performance Respiratory Index Severity Children (RISC) modified RISC (mRISC) scores child...
Background The mortality impact of pulse oximetry use during infant and childhood pneumonia management at the primary healthcare level in low-income countries is unknown. We sought to determine outcomes infants children diagnosed referred using clinical guidelines with or without Malawi. Methods findings conducted a data linkage study prospective health facility community case data. matched prospectively collected worker (CHW) centre (HC) outpatient hospital community-based surveillance...
Abstract The OpenOximetry Dataset stores clinical and lab pulse oximetry data. It supports measurements of arterial oxygen saturation (SaO2) by blood gas co-oximetry (SpO2), alongside processed unprocessed photoplethysmography (PPG) data other metadata. This includes skin color measurements, finger diameter, vital signs (e.g., pressure, end-tidal carbon dioxide), parameters acid-base balance, hemoglobin concentration). All data, from desaturation studies to trials, are collected...
Introduction Existing risk assessment tools to identify children at of hospitalised pneumonia-related mortality have shown suboptimal discriminatory value during external validation. Our objective was derive and validate a novel tool aged 2–59 months across various settings. Methods We used primary, baseline, patient-level data from 11 studies, including evaluated for pneumonia in 20 low-income middle-income countries. Patients with complete were included logistic regression model assess the...
ObjectivesWe determined the pulse oximetry benefit in pediatric pneumonia mortality risk stratification and chest-indrawing in-hospital factors.MethodsWe report characteristics pneumonia-related of children aged 2-59 months who were included Pneumonia Research Partnership to Assess WHO Recommendations dataset. We developed multivariable logistic regression models identify factors.ResultsAmong 285,839 children, 164,244 (57.5%) from hospital-based studies included. case fatality (CFR) without...
We describe hypoxemic pneumonia prevalence in outpatient and inpatient settings, in-hospital mortality, clinical guideline performance for identifying hypoxemia young infants Malawi. In this retrospective analysis of a prospective cohort study, we investigate younger than 2 months participating surveillance at seven hospitals 18 health centers Malawi between 2011 2014. Logistic regression, multiple imputation with chained equations, pattern mixture modeling were used to determine the...
To assess the frequency, interventions, and outcomes of children presenting with traumatic brain injury or infectious encephalopathy in low-resource settings.Prospective study.Four hospitals Sub-Saharan Africa.Children age 1 day to 17 years old evaluated at hospital encephalopathy.None.We frequency consecutively over 4 weeks any department encephalopathy. Pediatric Cerebral Performance Category score was assessed pre morbidity discharge. Overall, 130 were studied (58 [45%] had injury) from...
Existing scores to identify children at risk of hospitalized pneumonia-related mortality lack broad external validation. Our objective was externally validate three such scores. We applied the Respiratory Index Severity in Children (RISC) for HIV-negative children, RISC-Malawi, and Pneumonia Etiology Research Child Health (PERCH) REsearch Partnerships Assess WHO REcommendations (PREPARE) data set. The PREPARE set includes pooled from 41 studies on pediatric pneumonia across world. calculated...
The burden of pediatric critical illness and resource utilization by children with in limited settings (RLS) are largely unknown. Without specific data that captures key aspects illness, disease presentation, for populations RLS, development a contextual framework appropriate, evidence-based interventions to guide allocation but available resources is challenging. We present this methods paper which describes our efforts determine the prevalence, etiology, hospital outcomes, associated...
Objective: To describe characteristics of patients evaluated for carbon monoxide exposure during Winter Storm Uri and the associated Texas power grid failure to explore whether specific communities in Greater Houston were disproportionately affected.Study Design: This retrospective cross-sectional study investigates all between February 13-17, 2021, at emergency centers a quaternary children’s hospital system Houston, Texas. Individual, household, neighborhood evaluated. We reported...
Background WHO defines hypoxaemia, a low peripheral arterial oxyhaemoglobin saturation (SpO 2 ), as <90%. Although hypoxaemia is an important risk factor for mortality of children with respiratory infections, the optimal SpO threshold defining uncertain in low-income and middle-income countries (LMICs). We derived from well Bangladesh residing at altitude. Methods prospectively enrolled well, aged 3–35 months participating pneumococcal vaccine evaluation Sylhet district, between June...
Traumatic brain injury (TBI) is a leading cause of morbidity and mortality in low- middle-income countries (LMICs). Hospital care practices pediatric TBI patients LMICs are unknown. Our objective was to report on hospital management outcomes children with three centers LMICs.We completed secondary analysis prospective observational study (<18 years) over 4-week period. Outcome determined by Pediatric Cerebral Performance Category (PCPC) score; an unfavorable score defined as PCPC > 2 or...
Background Pulse oximeters are not routinely available in outpatient clinics low- and middle-income countries. We derived clinical scores to identify hypoxemic child pneumonia. Methods This was a retrospective pooled analysis of two datasets 3–35 month olds with World Health Organization (WHO)-defined pneumonia Bangladesh Malawi. constructed, internally validated, compared fit &amp; discrimination four models predicting SpO 2 &lt; 93% &lt;90%: (1) Integrated Management Childhood...
Abstract Background The existing World Health Organization (WHO) pneumonia case management guidelines rely on clinical symptoms and signs for identifying, classifying, treating in children up to 5 years old. We aimed collate an individual patient-level data set from large, high-quality pre-existing studies identify a of with greater validity the diagnosis, prognosis, possible treatment childhood improvement current guidelines. Methods Using published systematic review expert knowledge, we...
Extreme cold in February 2021 precipitated prolonged power failure Texas. In Houston, many patients presented for carbon monoxide exposure from neighborhoods with lower per capita income, higher rates of limited English proficiency, and median Social Vulnerability Indices than Greater Houston. Weather-related disasters disproportionately affect socially vulnerable communities.
ABSTRACT Background Hypoxemia predicts mortality at all levels of care, and appropriate management can reduce preventable deaths. However, pulse oximetry oxygen therapy remain inaccessible in many primary care health facilities. We aimed to develop validate a simple risk score comprising commonly evaluated clinical features predict hypoxemia 2-59-month-old children with pneumonia. Methods Data from 7 studies conducted 5 countries the Pneumonia Research Partnership Assess WHO Recommendations...
Abstract The OpenOximetry Repository is a structured database storing clinical and lab pulse oximetry data, serving as centralized repository data model for initiatives. It supports measurements of arterial oxygen saturation (SaO2) by blood gas co-oximetry (SpO2), alongside processed unprocessed photoplethysmography (PPG) other metadata. This includes skin color measurements, finger diameter, vital signs (e.g., pressure, end-tidal carbon dioxide), parameters acid-base balance, hemoglobin...