A5053692538- Cardiovascular Function and Risk Factors
- Non-Invasive Vital Sign Monitoring
- Optical Imaging and Spectroscopy Techniques
- Infrared Thermography in Medicine
- Cardiac Valve Diseases and Treatments
- Hemodynamic Monitoring and Therapy
- Nanoplatforms for cancer theranostics
- Photoacoustic and Ultrasonic Imaging
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Photodynamic Therapy Research Studies
- Cardiac pacing and defibrillation studies
- Vascular Malformations and Hemangiomas
- Heart Rate Variability and Autonomic Control
- Cardiovascular Health and Disease Prevention
- Cancer Research and Treatments
- Skin Protection and Aging
- Tumors and Oncological Cases
- Mechanical Circulatory Support Devices
- Systemic Sclerosis and Related Diseases
- Spectroscopy Techniques in Biomedical and Chemical Research
- Cardiovascular and exercise physiology
- Thermography and Photoacoustic Techniques
- Anatomy and Medical Technology
- Thermoregulation and physiological responses
Washington University in St. Louis
2013-2025
University of California, San Francisco
2023
Optica
2022
American Academy of Dermatology
2022
Harvard University
2002
When a drop of aqueous solution containing suspended particles dries, accumulate at the contact line. Often line undergoes sequence pinning−depinning events with accumulating whenever is pinned. These processes lead to ring formation, details which are examined here. In particular, we provide detailed measurements formation as function radius and size particles, report time dependence essentially stochastic cycles motion.
Fingertip pulse oximeters are widely available, inexpensive, and commonly used to make clinical decisions in many settings. Device performance is largely unregulated poorly characterised, especially people with dark skin pigmentation.
For noninvasive light-based physiological monitoring, optimal wavelengths of individual tissue components can be identified using absorption spectroscopy. However, because the lack sensitivity hardware at longer wavelengths, spectroscopy has typically been applied for in visible (VIS) and near-infrared (NIR) range from 400 to 1,000 nm. Hardware advancements short-wave infrared (SWIR) have enabled investigators explore ~1,000 nm 3,000 which fall characteristic peaks lipid, protein, water....
Background: Vascular malformations (VMs) are a collection of rare diseases that result from abnormal overgrowth vascular tissue and can lead to pain, infection, disfigurement, decreased mobility. invade or impinge on nearby structures, including nerves, causing numbness, and/or functional impairment. If nonsurgical therapy fails, surgical resection is considered. However, VMs’ thin walls tendency infiltrate recur makes difficult impossible. Rather than resecting, we have found patients still...
Some pulse oximeters perform worse in people with darker skin, and this may be due to inadequate diversity of skin pigment device development study cohorts. Guidance is needed accurately equitably characterize ensure research We tested multiple methods for characterizing assess comparability impact on cohort diversity. Assess reliability common measurement methodsCompare findings from different anatomical sitesDemonstrate that cannot assumed US National Institutes Health (NIH) race...
Significance: Detection and characterization of circulating tumor cells (CTCs), a key determinant metastasis, are critical for determining risk disease progression, understanding metastatic pathways, facilitating early clinical intervention. Aim: We aim to demonstrate label-free imaging suspected melanoma CTCs. Approach: use linear-array-based photoacoustic tomography system (LA-PAT) detect CTCs, quantify their contrast-to-noise ratios (CNRs), measure flow velocities in most the superficial...
Maximum elastance is an experimentally validated, load-independent systolic function index stemming from the time-varying paradigm that decoupled extrinsic load (intrinsic) contractility. Although Doppler echocardiography preferred method of diastolic (DF) assessment, all echo-derived indexes are dependent, and no invasive or noninvasive filling (LIIF) exists. In this study, we derived validated a LIIF. We used kinematic (the parameterized formalism) to predict derive (dimensionless) dynamic...
Average left ventricular (LV) chamber stiffness (Delta P(avg)/Delta V(avg)) is an important diastolic function index. An E-wave-based determination of Delta V(avg) (Little WC, Ohno M, Kitzman DW, Thomas JD, Cheng CP. Circulation 92: 1933-1939, 1995) predicted that deceleration time (DT) determines as follows: = N(pi/DT)(2) (where N constant), which implies if the DTs two LVs are indistinguishable, their indistinguishable well. We observed with may have markedly different values determined by...
During early rapid filling, blood aspirated by the left ventricle (LV) generates an asymmetric toroidal vortex whose development has been quantified using formation time (VFT), a dimensionless index defined length-to-diameter ratio of (equivalent cylindrical) fluid column. Since LV wall motion atrioventricular pressure gradient resulting in transmitral flow (Doppler E-wave) and associated formation, we hypothesized that causal relation between VFT diastolic function (DF), parametrized...
Disparities in surgical outcomes often result from subjective decisions dictated by training, experience, and available resources. To improve outcomes, surgeons have adopted advancements robotics, endoscopy, intra-operative imaging including fluorescence-guided surgery (FGS), which highlights tumors anatomy real-time. However, technical, economic, logistic challenges hinder widespread adoption of FGS beyond high-resource centers. overcome these impediments, we combined laser diodes,...
In current practice, empirical parameters such as the monoexponential time constant tau or logistic model tauL are used to quantitate isovolumic relaxation. Previous work indicates that and load dependent. A load-independent index of pressure decline (LIIIVPD) does not exist. this study, we derive validate a LIIIVPD. Recently, have derived validated kinematic decay (IVPD), where IVPD is accurately predicted by solution an equation motion parameterized stiffness (Ek), relaxation (tauc),...