Effects of regional diastolic pressure differences within the left ventricle on measured transmitral pressure-flow relation were determined by simultaneous micromanometric atrial (LAP) and ventricular (LVP) measurements, Doppler echocardiograms in 11 anesthetized, closed-chest dogs. Intraventricular recordings at sites that 2, 4, 6 cm from apex obtained. Profound between these noted during early (preatrial) filling. In measurements to base, minimum LVP increased (1.6 +/- 0.7 3.1 0.8 mm Hg,...

A recurring difficulty in the Minimal Model Program is that while log terminal singularities are quite well behaved (for instance, they rational), canonical much more complicated; need not even be Cohen-Macaulay. The aim of this paper to prove Du Bois. concept Bois singularities, introduced by Steenbrink, a weakening rationality. We also flatness cohomology sheaves relative dualizing complex projective family with fibers. This implies each connected component moduli space stable varieties...

Background— Heart failure with preserved ejection fraction (HFPEF) involves of cardiovascular reserve in multiple domains. In HFPEF animal models, dietary sodium restriction improves ventricular and vascular stiffness function. We hypothesized that the sodium-restricted approaches to stop hypertension diet (DASH/SRD) would improve left diastolic function, arterial elastance, ventricular–arterial coupling hypertensive HFPEF. Methods Results— Thirteen patients treated compensated consumed...

The duration of diastole can be defined in terms mechanical events. Mechanical diastolic (MDD) is comprised by the phases early rapid filling (E wave), diastasis, and late atrial (A wave). effect heart rate (HR) on predictable from kinematic modeling known cellular physiology. To determine dependence MDD each phase velocity time integral (VTI) HR, simultaneous transmitral Doppler flow velocities ECG were recorded during supine bicycle exercise healthy volunteers. Durations, peak values, VTI...

A new parametrized diastolic filling (PDF) formalism for evaluation of holodiastolic (left and right) ventricular function via Doppler echocardiography is presented. It motivated by the empiric observation that during diastole heart behaves as a suction pump whose dynamics, in certain respects, are those damped harmonic oscillator. An expression elastic recoil (suction) initiated fluid inflow velocity v(t) obtained differentiation from solution x(t) linear differential equation describes...

A consistent pattern of intraventricular regional pressure gradients exists under physiological conditions during the rapid filling phase diastole in normal dog left ventricle. We hypothesized that this gradient is caused, part, by early diastolic recoil ventricular walls conjunction with release elastic potential energy stored systole, generating suction and thus contributing to filling. If so, any condition interferes systolic function might be expected modify gradients. Accordingly,...

Abstract The laws of fluid dynamics govern vortex ring formation and precede cardiac development by billions years, suggesting that diastolic is instrumental in defining the shape heart. Using novel validated magnetic resonance imaging measurements, we show healthy left ventricle moves tandem with expanding ring, indicating form function epigenetically optimized to accommodate for volume pumping. Healthy hearts demonstrate a strong coupling between volumes (R 2 = 0.83), but this phenotype...

Although modeling the four-chambered heart as a constant-volume pump successfully predicts causal physiological relationships between cardiac indexes previously deemed unrelated, real slightly deviates from state by ventricular end systole. This deviation has consequences that affect chamber function, specifically, left atrial (LA) function. LA attributes have been characterized booster pump, reservoir, and conduit functions, yet characterization of their temporal occurrence or relationship...

We prove that any coarse moduli space of stable log-varieties general type is projective. also subadditivity log-Kodaira dimension for fiber spaces whose log type.

Two complementary mathematical modelling approaches are covered. They contrast the degree of and computational sophistication that can be applied to cardiovascular physiology problems they highlight differences between a fluid dynamic versus kinematic (lumped parameter) approach. McQueen & Peskin model tissue as being incompressible, having essentially uniform mass density, apply modified form Navier–Stokes equations four chambered heart great vessels. Using supercomputer their solution...

A chamber stiffness ( K LV )-transmitral flow (E-wave) deceleration time relation has been invasively validated in dogs with the use of average [(ΔP/ΔV) avg ]. is equivalent to k E , parameterized diastolic filling model. Prediction and validation 1) (ΔP/ΔV) terms 2) early rapid-filling ] 3) passive (postdiastasis) PD from waves parameter for Doppler wave ) have not achieved. Simultaneous micromanometric left ventricular (LV) pressure (LVP) transmitral 131 subjects were analyzed. (ΔP) (ΔV)...

Abstract Given a normal variety Z , p -form σ defined on the smooth locus of and resolution singularities $\pi : \widetilde {Z} \to Z$ we study problem extending pull-back π * ( ) over -exceptional set $E \subset {Z}$ . For log canonical pairs for certain values show that an extension always exists, possibly with logarithmic poles along E As corollary, it is shown sheaves reflexive differentials enjoy good properties. A natural generalization well-known Bogomolov–Sommese vanishing theorem to...

Chronic Kidney Disease (CKD) is a global health concern and frequently underdiagnosed due to its subtle initial symptoms, contributing increasing morbidity mortality. A comprehensive understanding of CKD comorbidities could lead the identification risk-groups, more effective treatment improved patient outcomes. Our research presents two-fold objective: developing an machine learning (ML) workflow for text classification entity relation extraction assembling broad list diseases influencing...

Let X be a proper complex variety with Du Bois singularities. Then H(X,C)→ H(X,) is surjective for all i. This property makes this class of singularities behave well regard to Kodaira type vanishing theorems. Steenbrink conjectured that rational are and Kollár log canonical Bois. also under some reasonable extra conditions canonical. In article Steenbrink's conjecture proved in its full generality, Kollár's first second set conditions, shown these cannot relaxed.

The constant-volume hypothesis regarding the four-chambered heart states that total pericardial volume remains invariant throughout cardiac cycle. Previous canine studies have indicated constant within 5%; however, this has not been validated in humans using state-of-the-art technology. several predictable functional consequences, including a relationship between atrial ejection fraction and chamber equilibrium volumes. Using magnetic resonance (MR) imaging (MRI), we measured extent to which...