Joseph J. Zhao
A5024614139- Cancer Immunotherapy and Biomarkers
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Treatments and Mutations
- Esophageal Cancer Research and Treatment
- Colorectal Cancer Treatments and Studies
- Cancer Genomics and Diagnostics
- Lung Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Renal cell carcinoma treatment
- Advanced Breast Cancer Therapies
- Pancreatic and Hepatic Oncology Research
- Breast Cancer Treatment Studies
- Lung Cancer Research Studies
- Cancer Cells and Metastasis
- Single-cell and spatial transcriptomics
- Radiomics and Machine Learning in Medical Imaging
- Ferroptosis and cancer prognosis
- Advanced Causal Inference Techniques
- Minimally Invasive Surgical Techniques
- Vascular Procedures and Complications
- Central Venous Catheters and Hemodialysis
- Appendicitis Diagnosis and Management
- Liver Disease Diagnosis and Treatment
- Cancer-related Molecular Pathways
National University of Singapore
2020-2025
National University Cancer Institute, Singapore
2023-2025
National University Hospital
2023-2025
Duke-NUS Medical School
2024-2025
Singapore General Hospital
2021-2023
National Cancer Centre Singapore
2023
UCLA Medical Center
2023
Singapore College of Traditional Chinese Medicine
2021-2022
Ministry of Health
2022
Hangzhou Cancer Hospital
2018
Laparoscopic and robotic techniques have both been well adopted as safe options in selected patients undergoing hepatectomy. However, it is unknown whether either approach superior, especially for major hepatectomy such right or extended (RH/ERH).To compare the outcomes of vs laparoscopic RH/ERH.In this case-control study, propensity score matching analysis was performed to minimize selection bias. Patients RH/EHR at 29 international centers from 2008 2020 were included.Robotic RH/ERH.Data...
Abstract Gastric cancer (GC) is a major cause of global mortality with high levels heterogeneity. To explore geospatial interactions in tumor ecosystems, we integrated 2,138 spatial transcriptomic regions-of-interest (ROIs) 152,423 single-cell expression profiles across 226 GC samples from 121 patients. We observed pervasive expression-based intratumor heterogeneity, recapitulating progression through spatially localized and functionally ordered subgroups associated specific immune...
To compare the outcomes between robotic major hepatectomy (R-MH) and laparoscopic (L-MH).Robotic techniques may overcome limitations of liver resection. However, it is unknown whether R-MH superior to L-MH.This a post hoc analysis multicenter database patients undergoing or L-MH at 59 international centers from 2008 2021. Data on patient demographics, center experience volume, perioperative outcomes, tumor characteristics were collected analyzed. Both 1:1 propensity-score matched (PSM)...
Peritoneal metastasis (PM) in gastric cancer (GC) is associated with poor prognosis and significant morbidity. We sought to understand the genomic, transcriptomic, tumor microenvironment (TME) features that contribute peritoneal organotropism GC.
Objective: To compare the outcomes of robotic limited liver resections (RLLR) versus laparoscopic (LLLR) posterosuperior segments. Background: Both and have been used for tumors in However, comparative performance safety both approaches not well examined existing literature. Methods: This is a post hoc analysis multicenter database 5,446 patients who underwent RLLR or LLLR segments (I, IVa, VII VIII) at 60 international centers between 2008 2021. Data on baseline demographics, center...
The exact clinical course and factors associated with persistent endocrine immune-related adverse events (irAEs) are not well-established. Elucidation of these information will aid irAEs screening follow-up planning for patients on immunotherapy. We analysed the including thyroid pituitary dysfunction insulin-dependent diabetes mellitus (IDDM), identified dysfunction, determined association between survival parameters. This retrospective observational study enrolled metastatic cancer who...
Abstract Background Durvalumab consolidation is associated with improved survival following concurrent chemoradiotherapy (CCRT) in patients stage III non‐small cell lung cancer (NSCLC). Given the heterogeneity of NSCLC patients, this study we evaluated efficacy and safety durvalumab real‐world setting. Method Unresectable were retrospectively studied: one cohort received CCRT, another had CCRT‐durvalumab. Primary endpoints progression‐free (PFS) overall (OS), secondary relapse rate safety....
218 Background: Peritoneal metastases (PM) in colorectal cancer (CRC) portend a poor prognosis. We sought to elucidate spatially resolved molecular features facilitating transcoelomic dissemination and progression. Methods: 50 PT, 116 PM 37 primary normal samples from 96 patients were retrieved profiled with digital spatial profiling (GeoMx DSP, Nanostring Technologies). Through unsupervised clustering, we characterized the microenvironment of tumor-stroma compartments studied roles stromal...
Background Immune checkpoint inhibitors (ICIs) are the gold standard therapy in patients with deficient mismatch repair (dMMR)/microsatellite instability-high (MSI-H) metastatic colorectal cancer (mCRC). A significant proportion of show resistance, making identification determinants response crucial. Growing evidence supports role sex determining susceptibility to anticancer therapies, but data is lacking for MSI-H CRC. Methods In this real-world cohort comprising 624 mCRC receiving ICIs, we...
Abstract Background Within the tumor microenvironment (TME), association of B lymphocytes (B cells) with prognosis and therapy response in gastric cancer (GC) remains poorly characterized. We investigated predictive prognostic value cells, including their spatial organization within TME, one largest multi-cohort studies to date. Methods Using CD20 immunohistochemistry, we evaluated cell density resection specimens from 977 patients resectable GC across three cohorts, randomized phase III...
<div>Abstract<p>Gastric cancer is a major cause of global mortality. To explore geospatial interactions in gastric tumors, we integrated 2,138 spatial transcriptomic regions interest with 152,423 single-cell expression profiles across 226 samples from 121 patients. We observed pervasive expression-based intratumor heterogeneity, recapitulating tumor progression through spatially localized and functionally ordered subgroups associated specific immune microenvironments, checkpoint...
<p>(1) Supplementary Figure 1 shows morphologies of different ROI categories and their representative genes, pathways similarities with paired scRNA-seq data. (2) 2 validation findings from the discovery GeoMx DSP cohort in whole-section also TMA cohort. (3) 3 experiments validating that intratumor G1/G2 subregion expression is tumor-intrinsic using multiplexed IHC, Stereoseq spatial transcriptomics, vitro drug treatment profiling. (4) 4 individual immune checkpoints, chemokines,...