A5042086613- HER2/EGFR in Cancer Research
- Advanced Breast Cancer Therapies
- Cancer Immunotherapy and Biomarkers
- Breast Cancer Treatment Studies
- Cancer Treatment and Pharmacology
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- Chemotherapy-related skin toxicity
- Colorectal Cancer Treatments and Studies
- Head and Neck Cancer Studies
- BRCA gene mutations in cancer
- Lung Cancer Research Studies
- Genetic factors in colorectal cancer
- Gastrointestinal Tumor Research and Treatment
- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Viral-associated cancers and disorders
- Lung Cancer Treatments and Mutations
- Lymphoma Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Angiogenesis and VEGF in Cancer
- Pancreatic and Hepatic Oncology Research
- Cancer survivorship and care
- Hair Growth and Disorders
- Ferroptosis and cancer prognosis
National University Cancer Institute, Singapore
2017-2025
National University Hospital
2020-2025
National University Health System
2019-2024
National University of Singapore
2022
Prince of Wales Hospital
2017
Chinese University of Hong Kong
2017
University of Toronto
2014
Maritime and Port Authority of Singapore
2000
Circulating cell-free Epstein-Barr virus (EBV) DNA is a biomarker for nasopharyngeal carcinoma. We conducted prospective study to investigate whether EBV in plasma samples would be useful screen early carcinoma asymptomatic persons.We analyzed specimens participants who did not have symptoms of Participants with initially positive results were retested approximately 4 weeks later, and those persistently underwent nasal endoscopic examination magnetic resonance imaging (MRI).A total 20,174...
Colorectal cancer (CRC) remains a significant global health challenge, ranking among the leading causes of cancer-related morbidity and mortality worldwide. Recent advancements in molecular characterization have revolutionized our understanding heterogeneity within colorectal tumors, particularly context tumor sidedness. Tumor sidedness, referring to location primary either right or left colon, has emerged as critical factor influencing prognosis treatment responses metastatic CRC. Molecular...
Abstract Background Durvalumab consolidation is associated with improved survival following concurrent chemoradiotherapy (CCRT) in patients stage III non‐small cell lung cancer (NSCLC). Given the heterogeneity of NSCLC patients, this study we evaluated efficacy and safety durvalumab real‐world setting. Method Unresectable were retrospectively studied: one cohort received CCRT, another had CCRT‐durvalumab. Primary endpoints progression‐free (PFS) overall (OS), secondary relapse rate safety....
We evaluated the relevance of PD-1+CD8+ T-cells in gastric cancer (GC) including prognostic significance, association with chemotherapy and immunotherapy sensitivity correlations tumor microenvironment (TME).Discovery cohort: GC samples were for AE1/3, CD8, PD-1, Ki-67 Granzyme-B expression fluorescence-based multiplex immunohistochemistry (mIHC). Validation cohorts: we analyzed bulk RNAseq datasets from TCGA, "3G" trial an phase 2 trial. The cox proportional hazards model was used to...
Scalp cooling is standard-of-care for prevention of chemotherapy-induced alopecia (CIA), with proven safety and efficacy. Limb cryotherapy has shown promise in preventing peripheral neuropathy (CIPN). The safe application concomitant scalp limb cryotherapies during chemotherapy crucial due to concerns about potential interactions, including central hypothermia, yet limited data exist on their delivery this context. Here we report a prospective, single-arm study assessing feasibility, safety,...
Multiple primary cancers (MPC) are an indicator of potential hereditary cancer predisposition syndrome. There remains insufficient data on genetic testing outcomes and the optimal panel for MPC. We evaluated prevalence MPC, spectrum pathogenic germline variants (PGVs) role extended in Cancer patients seen a genetics clinic tertiary centre Singapore from 2000 to 2023 were included. Clinical characteristics, PGV patterns analysed. Most tested with 49 genes, but selected 156 216 genes was...
Abstract Introduction: Peripheral blood mononuclear cells (PBMCs) are key mediators of immune surveillance and response against malignancies. Profiling PBMC subsets provides insights into dynamics in cancer progression therapeutic response, reflecting systemic changes that may mirror the tumor microenvironment. This study aimed to identify differences profiles between colorectal (CRC) patients deriving clinical benefit from first-line therapy those with poor outcomes. Methods: We recruited...
Developing multiple cancers is an indicator of underlying hereditary cancer predisposition, but there a paucity data regarding the clinical genetic testing outcomes these patients.We compared index patients with ≥2 primary malignancies versus 1 who underwent evaluation and multi-gene panels comprising up to 49 genes from 1998-2016.Among 1191 patients, 80.6%, 17.2%, 2.2% respectively had 1, 2, ≥3 malignancies. For 2 (n=205), most common pairs were bilateral breast (37.5%), breast-ovary...
Abstract Purpose Severe peripheral neuropathy is a common dose-limiting toxicity of taxane chemotherapy, with no effective treatment. Frozen gloves have shown to reduce the severity in several studies but comes incidence undesired side effects such as cold intolerance and frostbite extreme cases. A device thermoregulatory features which can safely deliver tolerable amounts cooling while ensuring efficacy required overcome deficiencies frozen gloves. The role continuous-flow prevention...
<b><i>Background:</i></b> The approved doses of the single agent nivolumab – an anti-programmed cell death protein 1 (PD-1) monoclonal antibody for renal carcinoma (RCC) are 3 mg/kg and a 240-mg flat dose, despite efficacy shown at lower in earlier CheckMate trials. In view financial constraints, minimum dose required remains critical area inquiry. <b><i>Methods:</i></b> A retrospective review RCC patients receiving single-agent anti-PD-1...
Oestrogen receptor positive, human epidermal growth factor receptor-2 (HER2) negative breast cancer (BC) is the most frequently diagnosed BC subtype. Combinations of cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) with anti-oestrogen therapy have led to improved survival compared alone for advanced/metastatic BC. The evaluation CDK4/6i in real-world facilitates treatment planning, insights into incidence drug toxicities, dose modifications including delays (DDs) and reductions (DRs)...
Abstract Purpose: RET is an estrogen response gene with preclinical studies demonstrating cross-talk between the and receptor (ER) pathways. We investigate role of lenvatinib, a multikinase inhibitor potent activity against RET, in patients metastatic breast cancer. Patients Methods: advanced ER+/HER2− cancer were treated lenvatinib plus letrozole phase Ib/II trial. Primary objectives included safety recommended II dose (RP2D) determination Ib, objective rates (ORR) expansion. Results:...
Germline genetic testing is traditionally carried out in patients suspected with hereditary cancer syndrome for enhanced surveillance and/or preventive strategies, but increasingly therapeutic indications.
Induction cisplatin and gemcitabine chemotherapy is a standard treatment for locally advanced nasopharyngeal carcinoma (NPC). Inhibition of VEGF axis has been shown to promote maturation microvasculature improve perfusion. We conducted four-arm study assess the effect two doses either sunitinib or bevacizumab with in NPC.Patients treatment-naïve NPC were treated three cycles 3-weekly preceded by 1 week anti-VEGF therapy each cycle, followed concurrent chemoradiation: arm A patients received...
Abstract Purpose Tumor angiogenesis controlled predominantly by vascular endothelial growth factor and its receptor (VEGF-VEGFR) interaction plays a key role in the propagation of cancer cells. However, newly formed network blood vessels is disorganized leaky. Pre-treatment with anti-angiogenic agents can “normalize” tumor vasculature allowing effective intra-tumoral delivery standard chemotherapy. Immunohistochemistry (IHC) analysis was applied to investigate compare normalization effects...
The authors have retracted this article because of confidentiality obligations. content has been removed for legal reasons. All agree to retraction. Response targeted therapy or chemotherapy following immunotherapy in patients with gastrointestinal cancers - a case
Peripheral Nerve Sheath Tumors (PNST) are a diverse group of mostly benign tumours uncommon in the general population. About 5-10% PNSTs hereditary, predominantly arising from germline variants NF1, NF2, SMARCB1, or LZTR1 gene.We reviewed clinical characteristics and genetic testing results patients referred to NCIS Adult Cancer Genetics Clinic for suspected hereditary PNST.3,001 have various cancer syndromes were evaluated between year 2000 March 2021. 13 (0.4%) clinically diagnosed PNSTs....