A5008045921- Peripheral Neuropathies and Disorders
- Cancer Treatment and Pharmacology
- Pain Mechanisms and Treatments
- Olfactory and Sensory Function Studies
- Botulinum Toxin and Related Neurological Disorders
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Infection Control and Ventilation
- Migraine and Headache Studies
- Advanced Chemical Sensor Technologies
- Chemotherapy-related skin toxicity
- Hereditary Neurological Disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- COVID-19 and healthcare impacts
- Advancements in Transdermal Drug Delivery
- Acute Ischemic Stroke Management
- Coffee research and impacts
- COVID-19 and Mental Health
- Trigeminal Neuralgia and Treatments
- Cardiac pacing and defibrillation studies
- SARS-CoV-2 and COVID-19 Research
- Antifungal resistance and susceptibility
- Cardiovascular Syncope and Autonomic Disorders
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Arrhythmias and Treatments
National University Hospital
1995-2025
National University of Singapore
2004-2025
National University Health System
2018-2024
Creative Commons
2023
Rohde & Schwarz (Germany)
2023
Hong Kong University of Science and Technology
2023
University of Hong Kong
2023
National University Cancer Institute, Singapore
2022
University Health System
2022
Colorado Permanente Medical Group
2021
BACKGROUND Aging is associated with changes of the systolic blood pressure that may increase cardiac work and myocardial flow at rest reduce reserve. This might be misinterpreted as age-related impairment coronary vasodilator capacity. METHODS AND RESULTS Myocardial was quantified after administration intravenous dipyridamole in 40 healthy volunteers (12 women 28 men) 13N-ammonia positron emission tomography. Eighteen normal subjects were less than 22 older 50 years (31 +/- 9 versus 64...
Coronavirus disease (COVID-19) causes an immunosuppressed state and increases risk of secondary infections like mucormycosis. We evaluated clinical features, predisposing factors, diagnosis outcomes for mucormycosis among patients with COVID-19 infection. This prospective, observational, multi-centre study included 47 consecutive mucormycosis, diagnosed during their course illness, between January 3 March 27, 2021. Data regarding demography, underlying medical conditions, illness treatment...
Coronavirus disease 2019 (COVID-19) has been associated with various neurologic manifestations, including anosmia, acute ischemic stroke, Guillain-Barré syndrome, and encephalopathy.c During the COVID-19 pandemic, physicians seeing patients these manifestations should consider as a differential diagnosis to prevent diagnostic delays further transmission of disease.c Cranial nerve involvement could potentially be COVID-19. Oy-sters cWhen patient presents isolated facial palsy, careful...
Background and aimCOVID-19 pandemic has resulted in an unprecedented increased usage of Personal protective equipment (PPE) by healthcare-workers. PPE causes headache majority users. We evaluated changes cerebral hemodynamics among healthcare-workers using PPE.MethodsFrontline donning at our tertiary center were included. Demographics, co-morbidities blood-pressure recorded. Transcranial Doppler (TCD) monitoring middle artery was performed with 2-MHz probe. Mean flow velocity (MFV)...
Abstract Background and purpose COVID-19 pandemic led to wide-spread use of face-masks, respirators other personal protective equipment (PPE) by healthcare workers. Various symptoms attributed the PPE are believed be, at least in part, due elevated carbon-dioxide (CO2) levels. We evaluated concentrations CO2 under various PPE. Methods In a prospective observational study on healthy volunteers, levels were measured during regular breathing while donning 1) no mask, 2) JustAir® powered air...
Impaired sense of smell occurs in a fraction patients with COVID-19 infection, but its effect on cerebral activity is unknown. Thus, this case report investigated the infection frontotemporal cortex during olfactory stimuli. In preliminary study, who recovered from (n = 6) and healthy controls never contracted were recruited. Relative changes oxy-hemoglobin stimuli was acquired using functional near-infrared spectroscopy (fNIRS). The area under curve (AUC) for time interval 5 s before 15...
Olfactory dysfunction in neurodegenerative conditions such as Parkinson's syndrome and Alzheimer's disease can hallmark onset. We hypothesized that patients with diabetes mellitus, a condition featuring peripheral central neurodegeneration, would have decreased olfaction abilities. examined participants diabetic neuropathy, without control blinded fashion using standardized Sniffin' Sticks. Diabetic neuropathy severity was quantified the Utah Early Neuropathy Scale. Further subcategorization...
ABSTRACT Introduction We present a painful small‐fiber neuropathy variant of Guillain‐Barré syndrome characterized by antecedent infectious symptoms, hyporeflexia, and albuminocytologic dissociation. Methods Two patients received intravenous immunoglobulin, one corticosteroids. Results The subsequently improved. Immunoglobulin G (IgG) antibodies in their acute phase sera strongly bound to murine small nerve fibers, the binding disappeared during convalescent phase. Serum transfer nociceptive...
Small fiber neuropathy (SFN) is clinically and etiologically heterogeneous. Although autoimmunity has been postulated to be pathophysiologically important in SFN, few autoantibodies have described. We aimed identify associated with idiopathic SFN (iSFN) by a novel high-throughput protein microarray platform that captures expressed the native conformational state.Sera from 58 patients 20 age- gender-matched healthy controls (HCs) were screened against >1,600 immune-related antigens....
Abstract: Ultrasmall superparamagnetic iron-oxide particles (USPIOs) loaded into stem cells have been suggested as a way to track cell transplantation with magnetic resonance imaging, but the labeling, and post-labeling proliferation, viability, differentiation, retention of USPIOs within yet be determined for each type USPIO. Molday ION Rhodamine B™ (BioPAL, Worcester, MA, USA) (MIRB) has shown USPIO labeling agent mesenchymal cells, glial progenitor lines. In this study, we evaluated MIRB...
Abstract Purpose Severe peripheral neuropathy is a common dose-limiting toxicity of taxane chemotherapy, with no effective treatment. Frozen gloves have shown to reduce the severity in several studies but comes incidence undesired side effects such as cold intolerance and frostbite extreme cases. A device thermoregulatory features which can safely deliver tolerable amounts cooling while ensuring efficacy required overcome deficiencies frozen gloves. The role continuous-flow prevention...
The COVID-19 pandemic has had an unprecedented impact on healthcare systems globally, giving rise to significant morbidity and mortality. Vaccination been widely regarded as the most important strategy contain pandemic. Whilst local side-effects of BNT-162b2 (Pfizer-BioNTech) vaccine are well known, concern emerged due sporadic reports immune-mediated adverse effects (Cines Bussel, 2021; Rela et al., 2021). As August 19, 2021, 4.54 million individuals received vaccines in Singapore (Oxford...
Allergic rhinitis (AR) is an extremely common disease worldwide and one of the top-ten reasons for a visit to primary care clinics. This study aimed investigate understanding current guidelines concepts management AR among general practitioners (GPs) in Singapore.A postal questionnaire was designed survey dispensing practice Singapore GPs.Two hundred GPs completed questionnaire. estimated be 10-40% total patient visits 50% clinics surveyed. There no significant difference diagnosis...
Prior studies have shown that plaque inflammation on FDG-PET and the symptomatic carotid atheroma lumen-stenosis (SCAIL) score were associated with recurrent ischemic events, but findings thus far not been widely validated. Therefore, we aimed to validate of prior studies.A single-center prospective cohort study recruited patients (1) recent TIA or stroke within past 30 days, (2) ipsilateral artery stenosis ≥50%, (3) considered for early revascularization. The maximum standardized uptake...
A 25-year-old banker, a nonsmoker and nondrinker, presented with pain in the hands feet for 4 weeks that progressed to involve shoulders hips. Pain was associated constipation, followed by diarrhea. He had no prior trauma, vaccinations, or infectious symptoms. Medical history noncontributory; he on medication. consulted numerous doctors pain, who noted transient urinary hesitancy, tachycardia, hypertension required short duration treatment antihypertensives. All symptoms except resolved...
This report illustrates an adult patient presenting with tumefactive acute disseminated encephalomyelitis complicating human swine influenza.Its presentation, diagnosis, investigation findings, course, and response to treatment are discussed herein.