A5101726597- Hematopoietic Stem Cell Transplantation
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Orthopaedic implants and arthroplasty
- Dental Implant Techniques and Outcomes
- Peptidase Inhibition and Analysis
- Total Knee Arthroplasty Outcomes
- Nutrition and Health in Aging
- Anatomy and Medical Technology
- Soft Robotics and Applications
- Bone Tissue Engineering Materials
- Cytomegalovirus and herpesvirus research
- Medical Imaging and Analysis
- Intensive Care Unit Cognitive Disorders
- Long-Term Effects of COVID-19
- Cardiac Arrest and Resuscitation
- Lung Cancer Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Frailty in Older Adults
- Renal Transplantation Outcomes and Treatments
- Plasma Diagnostics and Applications
- Phytochemical compounds biological activities
- Transplantation: Methods and Outcomes
- Immunotherapy and Immune Responses
Nagoya University Hospital
2012-2024
Hyogo University
2024
Fred Hutch Cancer Center
2021-2024
The University of Tokyo
2024
Saga University
2024
Hyogo Medical University
2007-2022
Teijin (Japan)
2016-2022
Okayama Prefecture
2022
Kyoto Medical Center
2022
Iwate Prefectural University
2021
We report the clinical and serologic features of Japanese patients with chronic inflammatory demyelinating polyneuropathy (CIDP) displaying anti-neurofascin-155 (NF155) immunoglobulin G4 (IgG4) antibodies.
The major problems in human leukocyte antigen (HLA)-mismatched stem cell transplantation (SCT) are graft failure and graft-versus-host disease (GVHD). Less-intensive regimens should be associated with a lower release of inflammatory cytokines possibly less GVHD. objective this study was to investigate whether HLA-haploidentical SCT can performed using nonmyeloablative conditioning pharmacologic GVHD prophylaxis, including glucocorticoids. Using consisting fludarabine, busulfan,...
An orally active, nonpeptide bradykinin (BK) B 2 receptor antagonist, FR173657 (E)‐3‐(6‐acetamido‐3‐pyridyl)‐N‐[N‐[2‐4‐dichloro‐3‐[(2‐methyl‐8‐quinolinyl) oxymethyl]phenyl]‐N‐methylaminocarbonyl‐methyl]acrylamide) has been identified. This compound displaced [ 3 H]‐BK binding to receptors present in guinea‐pig ileum membranes with an IC 50 of 5.6 × 10 −10 M and rat uterus 1.5 −9 M. It did not inhibit different specific radio‐ligand other sites. In human lung fibroblast IMR‐90 cells, 2.9 a K...
A novel class of potent, selective, and orally active non-peptide bradykinin (BK) B2 receptor antagonists were designed synthesized starting from 8-benzyloxyimidazo[1,2-a]pyridine derivative 2. The unique screening lead (2) was discovered by a two-step intentional random process, involving recognition the relationship between BK angiotensin II (Ang II) common structural features. Systematic chemical modification 2 elucidated requirements essential for binding affinity leading to...
Surgery for esophageal cancer is associated with high morbidity and mortality. Reduced pulmonary functions exercise capacity are known as risk factors complications after esophagectomy. The 6-minute walk distance (6MWD) measured by the test (6MWT) a simple field that can be used to evaluate functional of patients who undergo thoracic surgery. aim this study was association preoperative 6MWD postoperative in cancer. Records total 111 underwent surgery followed rehabilitation from January 2013...
ABSTRACT Introduction We present a painful small‐fiber neuropathy variant of Guillain‐Barré syndrome characterized by antecedent infectious symptoms, hyporeflexia, and albuminocytologic dissociation. Methods Two patients received intravenous immunoglobulin, one corticosteroids. Results The subsequently improved. Immunoglobulin G (IgG) antibodies in their acute phase sera strongly bound to murine small nerve fibers, the binding disappeared during convalescent phase. Serum transfer nociceptive...
Surgery for cancer of the thoracic esophagus is a challenging procedure associated with high morbidity and mortality. Perioperative rehabilitation has been introduced to promote early mobilization patients prevent postoperative pulmonary complications. The purpose present study was characterize preoperative functional exercise capacity, muscle strength, anxiety, depression, health-related quality life (QOL) in esophageal cancer, evaluate impact radical esophagectomy on these parameters. We...
Kinins, members of a family peptides released from kininogens by the action kallikreins, exhibit variety biological activities including vasodilation, increased vascular permeability, contraction smooth muscle cells, and activation sensory neurons. However, investigation physiological actions kinins has been greatly hampered because its effects are curtailed rapid proteolysis in blood, lung, liver. We describe pharmacological characteristics novel nonpeptide bradykinin receptor agonist...
1. A nonionic surfactant, Pluronic F68, was used in prolonged experimental and clinical extracorporeal circulation, data are presented which support the efficacy of use this agent. 2. Hemolysis fat embolism resulting from cardiopulmonary bypass with a bubble oxygenator were greatly reduced by surfactant. 3. The surfactant markedly prevented improved intravascular "sludging." 4. also fibrin deposition on filter oxygenator. 5. function pump not affected. 6. No adverse physiological effects...
The marked stimulatory effect of locally applied pepsin-digested bovine tracheal cartilage upon wound fibroplasia and collagen deposition has been well documented by Prudden his group.<sup>1,2</sup>Not only is its at the seventh postoperative day, but it shown<sup>3</sup>that phenomenon demonstrable a very early time in course healing persists approximately same relative advantage (over controls) until 11th day (the last which measurements were made). This stimulation repair process did not...
Recently we reported the identification of a series 8-[[3-(N-acylglycyl-N-methylamino)-2, 6-dichlorobenzyl]oxy]-3-halo-2-methylimidazo[1,2-a]pyridines as first orally active non-peptide bradykinin (BK) B2 receptor antagonists (1-3). These compounds inhibited specific binding [3H]BK to guinea pig ileum membrane preparations expressing receptors with nanomolar IC50's and also displayed in vivo functional antagonistic activities against BK-induced bronchoconstriction pigs at 1 mg/kg by oral...
The nonpeptide bradykinin (BK) B 2 receptor antagonist, FR165649 (8‐[2,6‐dichloro‐3‐[N‐[(E)‐4‐(N‐ methylcarbamoyl)cinnamidoacetyl] ‐N‐methylamino] benzyloxy] ‐2 ‐ methylquinoline), and agonist, FR190997 (8‐[2,6‐dichloro‐3‐[N‐[(E)‐4‐(N‐methylcarbamoyl) cinnamidoacetyl]‐N‐methylamino]benzyloxy]‐2‐methyl‐4‐(2‐pyridylmethoxy)quinoline) have been identified. These compounds a common chemical structure, the 2‐pyridylmethoxy group is only structural difference between them. Both displaced [ 3 H]‐BK...
Immobilization is often associated with decreased muscle elasticity. This condition known as contracture; however, the mechanism remains unclear. The purpose of this study was to clarify governing contracture in rat soleus by identifying changes ankle joint mobility, insoluble collagen concentration and type I III isoforms following 1- 3-week immobilizations. Following a 1-week immobilization, range motion (ROM) dorsiflexion declined 90% control value; additionally, ROM dropped 67.5% value...
The outcome of cord blood transplantation following reduced-intensity conditioning is suboptimal because fatal infection triggered by prolonged neutropenia and graft-versus-host disease (GVHD) in addition to graft rejection. Intrabone marrow injection (IBMI) may improve the providing better hematopoietic engraftment less GVHD. We therefore evaluated IBMI safety stem cell transplantation. Furthermore, we used unwashed avoid loss. Ten patients (median age = 61 years old) were enrolled. Cord...