Prashant Kadam
A5056011321- Hepatocellular Carcinoma Treatment and Prognosis
- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Connexins and lens biology
- Heme Oxygenase-1 and Carbon Monoxide
- Liver Disease Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- Renal cell carcinoma treatment
- Pluripotent Stem Cells Research
- Animal Genetics and Reproduction
- Xenotransplantation and immune response
- Biomedical Research and Pathophysiology
- Hernia repair and management
- Gastric Cancer Management and Outcomes
- Tissue Engineering and Regenerative Medicine
- Renal Transplantation Outcomes and Treatments
- MRI in cancer diagnosis
- Urological Disorders and Treatments
- Academic integrity and plagiarism
- Transplantation: Methods and Outcomes
- Amino Acid Enzymes and Metabolism
Government Medical College
2024
Vrije Universiteit Brussel
2016-2024
University Hospitals Birmingham NHS Foundation Trust
2020-2024
Lokmanya Tilak Municipal General Hospital and Lokmanya Tilak Municipal Medical College
2012-2024
University of Nottingham
2024
Marathwada Mitra Mandal's College of Pharmacy
2023
Mitra Biotech (India)
2019-2023
Queen Elizabeth Hospital Birmingham
2020-2022
Queen Elizabeth Hospital
2021
University Hospitals Bristol and Weston NHS Foundation Trust
2020
Bioactive compounds from marine flora and fauna have extensive past present use in the treatment of many diseases serve as interest both their natural form templates for synthetic modification. Several molecules isolated various organisms (microorganisms, algae, fungi, invertebrates, vertebrates) are currently under study at an advanced stage clinical trials, some them already been marketed drugs. This article gives overview current trends screening activity analysis metabolites resources....
Laparoscopic and robotic techniques have both been well adopted as safe options in selected patients undergoing hepatectomy. However, it is unknown whether either approach superior, especially for major hepatectomy such right or extended (RH/ERH).To compare the outcomes of vs laparoscopic RH/ERH.In this case-control study, propensity score matching analysis was performed to minimize selection bias. Patients RH/EHR at 29 international centers from 2008 2020 were included.Robotic RH/ERH.Data...
Abstract Background Minimally invasive right posterior sectionectomy (RPS) is a technically challenging procedure. This study was designed to determine outcomes following robotic RPS (R-RPS) and laparoscopic (L-RPS). Methods An international multicentre retrospective analysis of patients undergoing R-RPS versus those who had purely L-RPS at 21 centres from 2010 2019 performed. Patient demographics, perioperative parameters, postoperative were analysed retrospectively central database....
Robotic liver resections (RLR) may have the ability to address some of drawbacks laparoscopic (LLR) but few studies done a head-to-head comparison outcomes after anterolateral segment by two techniques.A retrospective study was conducted 3202 patients who underwent minimally invasive LR segments at 26 international centres from 2005 2020. Two thousand six hundred and cases met criteria which there were 358 RLR 1868 LLR cases. Perioperative compared between groups using 1:3 Propensity Score...
Abstract Background Limited liver resections (LLRs) for tumours located in the posterosuperior segments of are technically demanding procedures. This study compared outcomes robotic (R) and laparoscopic (L) LLR (IV, VII, VIII). Methods was an international multicentre retrospective analysis patients who underwent R-LLR or L-LLR at 24 centres between 2010 2019. Patient demographics, perioperative parameters, postoperative were analysed; 1 : 3 propensity score matching (PSM) coarsened exact...
Can full spermatogenesis be achieved after xenotransplantation of prepubertal primate testis tissue to the mouse, in or subcutaneously?Intratesticular supported differentiation immature germ cells from marmoset (Callithrix jacchus) into spermatids and spermatozoa at 4 9 months post-transplantation, while subcutaneous transplants, spermatogenic arrest was observed none transplants survived months.Auto-transplantation cryopreserved (ITT) could a potential fertility restoration strategy for...
Spermatogonial stem cell transplantation (SSCT) could become a fertility restoration tool for childhood cancer survivors. However, since in mice, the colonization efficiency of transplanted spermatogonial cells (SSCs) is only 12%, procedure needs to be improved before clinical implementation possible. Co-transplantation mesenchymal (MSCs) might increase SSCs by restoring SSC niche after gonadotoxic treatment. A mouse model long-term infertility was developed and used transplant (SSCT, n =...
Sub-fertility is one of the most common problems observed in crossbred males, but etiology remains unknown cases. Although proteomic differences spermatozoa and seminal plasma between breeds have been investigated, possible at sperm precursor cells supporting/nourishing not studied. The present study reports differential profile spermatogenic Sertoli purebred bulls. Testis was removed by unilateral castration 12 peri-pubertal bulls (10 months age), four each from (Holstein Friesian ×...
Research questionWhich cryopreservation method better protects reproductive potential: the of a testicular cell suspension (TCS) or tissue (TET)?DesignTwo strategies for spermatogonial stem cells (SSCs) were compared in mouse model: as TET TCS. Evaluated outcomes number viable after thawing, and length donor-derived colonies transplantation (SSCT), litters, litter size pups mating.ResultsCompared with cryopreserving TCS, resulted significantly higher numbers thawing (TET: 13.4 × 104 ± 7.2...
The potential of Compritol®888 ATO as a release modifier to retard the highly water soluble drug, metoprolol succinate (MPL) was exploited. Different ratios versus MPL were utilized and effect various formulation methods evaluated sustain MPL. MPL: in 1:2 ratio could successfully Melt granulation method "as hot process" found be effective when compared direct compression wet granulation. vitro characteristics tablets studied pH 6.8 phosphate buffer at 50 rpm using USP Type II apparatus....
The present study evaluated the effects of glial cell line-derived neurotrophic factor (GDNF), fibroblast growth (FGF) 2 and epidermal (EGF) on proliferation expression some genes in spermatogonial cells. Spermatogonial cells were isolated from prepubertal buffalo testes enriched by double enzyme treatment, filtration through 80- 60-μm nylon mesh filters, differential plating lectin-coated dishes Percoll density gradient centrifugation. Cells then cultured a Sertoli feeder layer formed...
Abstract Background Spermatogonial stem cell transplantation (SSCT) is a promising therapy in restoring the fertility of childhood cancer survivors. However, low efficiency SSCT significant concern. could be improved by co-transplanting transforming growth factor beta 1 (TGFβ1)-induced mesenchymal cells (MSCs). In this study, we investigated reproductive and safety spermatogonial (SSCs) TGFβ1-induced MSCs. Methods A mouse model for long-term infertility was used to transplant SSCs (SSCT, n =...
Carbuncles are debilitating skin infections commonly seen in diabetic patients. Excision of these infective lesions leads to large defects that require prolonged hospital stay and repeated dressings with ensuing pain bleeding. This study is an attempt cover the wounds resulting from excision carbuncle primary grafting so as decrease frequency dressings.