A5043887609- Antimicrobial Peptides and Activities
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease and Transplantation
- Immune Response and Inflammation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Antimicrobial Resistance in Staphylococcus
- Organ Transplantation Techniques and Outcomes
- Pancreatic and Hepatic Oncology Research
- Bacterial biofilms and quorum sensing
- Gallbladder and Bile Duct Disorders
- Neuropeptides and Animal Physiology
- Orthopedic Infections and Treatments
- Pancreatitis Pathology and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Biochemical and Structural Characterization
- Wound Healing and Treatments
- Infectious Aortic and Vascular Conditions
- Antimicrobial agents and applications
- Antibiotic Resistance in Bacteria
- Transplantation: Methods and Outcomes
- Urinary Tract Infections Management
- Neuroendocrine Tumor Research Advances
- Essential Oils and Antimicrobial Activity
Marche Polytechnic University
2016-2025
Ospedali Riuniti Umberto I
2012-2020
Azienda Ospedaliero Universitaria Ospedali Riuniti
2012-2020
Memorial Sloan Kettering Cancer Center
2017
University of Modena and Reggio Emilia
2016
Azienda Ospedaliero-Universitaria di Modena
2015
Bipar
2013
Istituti di Ricovero e Cura a Carattere Scientifico
2005-2008
Istituto Nazionale di Riposo e Cura per Anziani
2001-2008
I.R.C.C.S. Oasi Maria SS
2006-2008
Textbook outcome (TO) is a composite measure that captures the most desirable surgical outcomes as single indicator, yet to date TO has not been defined and assessed in field of laparoscopic liver resection (LLR) open (OLR).To obtain international agreement on definition surgery (TOLS) assess incidence LLR OLR large multicenter database using propensity-score matched analysis.Patients undergoing or for all diseases between January 2011 October 2019 were analyzed database. An survey was...
The quorum-sensing inhibitor RIP inhibits staphylococcal TRAP/agr systems and both TRAP- agr-negative strains are deficient in biofilm formation vivo, indicating the importance of quorum sensing to biofilms host. injected systemically into rats has been found have strong activity preventing methicillin-resistant Staphylococcus aureus graft infections, suggesting that can be used as a therapeutic agent.
Staphylococcus epidermidis is a frequent cause of infections associated with foreign bodies and indwelling medical devices. The bacteria are capable surviving antibiotic treatment through encapsulation into biofilms. RNAIII-inhibiting peptide (RIP) heptapeptide that inhibits S. aureus pathogenesis by disrupting quorum-sensing mechanisms. In this study, RIP inhibited drug-resistant biofilm formation mechanism similar to evidenced for aureus. synergistic antibiotics in eliminating 100%...
We investigated the efficacy of LL-37, C-terminal part only cathelicidin in humans identified to date (termed human cationic antimicrobial protein), three experimental rat models gram-negative sepsis. Adult male Wistar rats (i) were given an intraperitoneal injection 1 mg Escherichia coli 0111:B4 LPS, (ii) 2 x 10(10) CFU ATCC 25922, or (iii) had intra-abdominal sepsis induced via cecal ligation and puncture. For each model, all animals randomized receive intravenously isotonic sodium...
ABSTRACT Staphylococcus aureus is a prevalent cause of bacterial infections associated with indwelling medical devices. RNA III inhibiting peptide (RIP) known to inhibit S. pathogenesis by disrupting quorum-sensing mechanisms. RIP was tested in the present study for its ability biofilm formation rat Dacron graft model. The activity synergistic those antibiotics complete prevention drug-resistant infections.
To assess the possible effect of two different types preoperative transcatheter arterial chemoembolization (TACE) on recurrence-free survival after liver transplantation (LT) in patients with hepatocellular carcinoma (HCC) and to analyze effects TACE tumor histology.We retrospectively analyzed histological features 130 HCC nodules 63 native livers removed at transplantation. Patients who received any other type treatment such as radiofrequency ablation, percutaneous ethanol ablation or were...
Abstract Background Pancreas resection for metachronous colorectal cancer metastasis is episodic and the role of surgery in management these patients still debated. Methods We recruited seven from three different centres analyzed 30‐day morbidity mortality, oncological outcomes at 6 12 months. Results There was no postoperative mortality. Complications occurred two (28,6%). All completed least a 12‐months follow‐up. At 6‐month follow‐up, only one patient had recurrence. 12‐month died disease...
BackgroundMedical devices used in clinical practice are often associated with biofilm-associated staphylococcal infections
Bacteria that adhere to implanted medical devices play an important role in industry and modern medicine. Staphylococci are among the most common pathogens cause biomaterial infections. Vascular prosthetic graft infection is one of feared complications vascular surgeon treats, frequently resulting prolonged hospitalization, organ failure, amputation, death. A rat model was used investigate topical efficacies temporin quorum-sensing inhibitor RNAIII-inhibiting protein (RIP) as prophylactic...
ABSTRACT Sepsis remains a major cause of morbidity and mortality in hospitalized patients, despite intense efforts to improve survival. The primary lead for septic shock results from activation host effector cells by endotoxin, the lipopolysaccharide (LPS) associated with cell membranes gram-negative bacteria. For these reasons, quest compounds antiendotoxin properties is actively pursued. We investigated efficacy amphibian skin antimicrobial peptide temporin L binding Escherichia coli LPS...
Ureteral stents coated with the quorum-sensing inhibitor RNAIII-inhibiting peptide (RIP) were implanted in rat bladders and shown to suppress Staphylococcus aureus formation on stent urine was especially effective when combined teicoplanin. Coating ureteral RIP thus increases efficacy of teicoplanin preventing stent-associated staphylococcal infections.
IntroductionAn experimental study has been performed to compare the in vitro activity and vivo efficacy of magainin II cecropin A with or without rifampicin against control multidrug-resistant Pseudomonas aeruginosa strains.
We investigated the efficacy of tigecycline and FS8, alone or combined, in preventing prosthesis biofilm a rat model staphylococcal vascular graft infection. Graft infections were established back subcutaneous tissue adult male Wistar rats by implantation Dacron prostheses followed topical inoculation with 2 x 107 colony-forming units Staphylococcus aureus, strain Smith diffuse. The study included control group, contaminated group that did not receive any antibiotic prophylaxis, three groups...