Hui Chen

ORCID: 0009-0003-7413-575X
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About
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Research Areas
  • Risk and Safety Analysis
  • Single-cell and spatial transcriptomics
  • Cancer Genomics and Diagnostics
  • Structural Integrity and Reliability Analysis
  • Power System Reliability and Maintenance
  • Scientific Research and Discoveries
  • Atmospheric and Environmental Gas Dynamics
  • Nuclear Engineering Thermal-Hydraulics
  • Cancer Cells and Metastasis
  • Methane Hydrates and Related Phenomena
  • Maritime Navigation and Safety

Zhejiang Ocean University
2023-2025

Sichuan University
2025

West China Hospital of Sichuan University
2025

China National Nuclear Corporation
2023

Abstract Gastric cancer (GC) is a major cause of global mortality with high levels heterogeneity. To explore geospatial interactions in tumor ecosystems, we integrated 2,138 spatial transcriptomic regions-of-interest (ROIs) 152,423 single-cell expression profiles across 226 GC samples from 121 patients. We observed pervasive expression-based intratumor heterogeneity, recapitulating progression through spatially localized and functionally ordered subgroups associated specific immune...

10.1158/2159-8290.cd-24-0605 article EN cc-by-nc-nd Cancer Discovery 2025-01-08

Mesoscale eddies can affect the distribution of matter in ocean due to their inherent characteristics, thereby affecting local ecosystems. However, there are few previous studies on influence Great Whirl (GW) particulate organic carbon (POC). This study analyzes GW three-dimensional marine POC concentration northwestern Indian Ocean, off coast Somalia. It is shown that significant differences spatial modes surface and subsurface GW. In sea surface, at edge higher than eddy center resulting...

10.3389/fmars.2025.1505781 article EN cc-by Frontiers in Marine Science 2025-03-05

Component reliability data is an important basis for nuclear power plants to carry out Probabilistic Safety Analysis(PSA). There are many options the uncertainty distribution of parameters. In this paper, parameters in "Equipment Reliability Data Report on Nuclear Power Plant China"(version 2018) and U.S. NUREG/CR-6928 general database studied. Three types beta distribution, gamma lognormal used China's report, only selected NUREG/CR -6928 database. when estimated according classical...

10.1049/icp.2022.3026 article EN IET conference proceedings. 2023-01-13

With the increasing prosperity of maritime transport, tank cleaning process is particularly important. In order to reduce probability accidents caused by ship and improve safety, this paper applies analytic Hierarchy (AHP) -risk matrix method washing. Through clear establishment washing safety index system, risk divided into 5 secondary indexes 15 tertiary indexes, which systematically, comprehensively objectively reflect degree each index. The research shows that assessment model project...

10.1145/3656766.3656879 article EN 2023-11-24
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