A5086477049- Global Maternal and Child Health
- Southeast Asian Sociopolitical Studies
- Single-cell and spatial transcriptomics
- Pregnancy and preeclampsia studies
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Socioeconomic Development in Asia
Genome Institute of Singapore
2025
Chinese University of Hong Kong
2025
Sichuan University
2019
National Center for Women and Children’s Health, China CDC
2019
West China Second University Hospital of Sichuan University
2019
Abstract Gastric cancer (GC) is a major cause of global mortality with high levels heterogeneity. To explore geospatial interactions in tumor ecosystems, we integrated 2,138 spatial transcriptomic regions-of-interest (ROIs) 152,423 single-cell expression profiles across 226 GC samples from 121 patients. We observed pervasive expression-based intratumor heterogeneity, recapitulating progression through spatially localized and functionally ordered subgroups associated specific immune...
<div>Abstract<p>Gastric cancer is a major cause of global mortality. To explore geospatial interactions in gastric tumors, we integrated 2,138 spatial transcriptomic regions interest with 152,423 single-cell expression profiles across 226 samples from 121 patients. We observed pervasive expression-based intratumor heterogeneity, recapitulating tumor progression through spatially localized and functionally ordered subgroups associated specific immune microenvironments, checkpoint...
<p>(1) Supplementary Figure 1 shows morphologies of different ROI categories and their representative genes, pathways similarities with paired scRNA-seq data. (2) 2 validation findings from the discovery GeoMx DSP cohort in whole-section also TMA cohort. (3) 3 experiments validating that intratumor G1/G2 subregion expression is tumor-intrinsic using multiplexed IHC, Stereoseq spatial transcriptomics, vitro drug treatment profiling. (4) 4 individual immune checkpoints, chemokines,...
( Lancet . 2019;393:241–252) Mortality for both mother and child have been falling at impressive rates in China over the past 2 decades. Nationwide, maternal mortality dropped from 111.0 per 100,000 livebirths 1990 to 21.8 2015. However, has varied substantially among counties might also vary widely counties. Identifying experiencing less progress could help guide Chinese government allocating extra resources as needed meet Millennium Development Goal 5 (MDG 5) of decreasing rate by 75%...