A5101852210- Musculoskeletal pain and rehabilitation
- Spine and Intervertebral Disc Pathology
- Advanced Radiotherapy Techniques
- Inflammasome and immune disorders
- Esophageal Cancer Research and Treatment
- Anorectal Disease Treatments and Outcomes
- Cancer Research and Treatments
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Heme Oxygenase-1 and Carbon Monoxide
- Gastric Cancer Management and Outcomes
- Ion channel regulation and function
- RNA modifications and cancer
- Pelvic floor disorders treatments
- Breast Cancer Treatment Studies
- Pain Mechanisms and Treatments
- Ferroptosis and cancer prognosis
- Cancer Treatment and Pharmacology
- Anatomy and Medical Technology
- Periodontal Regeneration and Treatments
- RNA Research and Splicing
- Minimally Invasive Surgical Techniques
- Vascular anomalies and interventions
- Intestinal Malrotation and Obstruction Disorders
- Radiomics and Machine Learning in Medical Imaging
Institute of Neurobiology
2025
Fudan University
2007-2025
State Key Laboratory of Medical Neurobiology
2021-2025
Wenzhou Medical University
2024
Soochow University
2024
First Affiliated Hospital of Soochow University
2024
Shanghai Stomatological Hospital
2024
Nantong University
2022-2024
Zhejiang Cancer Hospital
2024
Chongqing University
2023
Thermosensation is vital for the survival, propagation, and adaption of all organisms, but its mechanism not fully understood yet. Here, we find that TMC6, a membrane protein unknown function, highly expressed in dorsal root ganglion (DRG) neurons functions as Gαq-coupled G protein-coupled receptor (GPCR)-like to sense noxious heat. TMC6-deficient mice display substantial impairment heat sensation while maintaining normal perception cold, warmth, touch, mechanical pain. Further studies show...
Existing treatments for chronic pain often prove ineffective and carry adverse side effects, highlighting the need better analgesics, including non-pharmacological treatments. We demonstrate that transcutaneous electrical nerve stimulation (TENS), when repeatedly applied during early phase of injury, produces sustained analgesic effects by activating dorsal column nucleus-thalamic-cortical pathway, which transmits vibration, discriminative touch, proprioception. Mechanistically, TENS...
Hypoxia-mediated inflammation plays a crucial role in renal ischaemia-reperfusion (IR)-induced acute kidney injury (AKI) and may influence graft survival, with no available pharmacological treatments. Here we investigate the protective effects mechanism of roxadustat (FG-4592), hypoxia-inducible factor stabilizer, against IR injury.The protein expression levels CD73 AIM2 inflammasome complex were examined biopsy specimens AKI post-renal transplantation (PRT) patients. The FG-4592 on absent...
Abstract Background As a metastasis-related protein, NEDD9 has been reported in breast cancer (BC) metastasis research. However, there are few studies on the upstream regulators of NEDD9, especially involving potential role miRNAs. The purpose this study was to explain whether miR-107 potentially regulates which may lead invasion and BC. Methods MCF-7 MDA-MB-231 cells were transduced with lentiviruses construct stably overexpression, silencing or empty vectors. A luciferase reporter assay...
Abstract Breast cancer (BC) remains a significant health concern worldwide, with metastasis being primary contributor to patient mortality. While advances in understanding the disease's progression continue, underlying mechanisms, particularly roles of long non‐coding RNAs (lncRNAs), are not fully deciphered. In this study, we examined influence lncRNA LINC00524 on BC invasion and metastasis. Through meticulous analyses TCGA GEO data sets, observed conspicuous elevation expression tissues....
Inflammatory response and renal fibrosis are the hallmarks of chronic kidney disease (CKD). However, specific mechanism aldosterone-induced injury in progress CKD requires elucidation. Emerging evidence has demonstrated that absent melanoma 2 (AIM2)-mediated inflammasome activation endoplasmic reticulum stress (ERS) play a pivotal role fibrosis. Here, we investigated whether overexpression or deficiency AIM2 affects ERS aldosterone-infused injury. Interestingly, found was markedly expressed...
Post-amputation pain causes great suffering to amputees, but still no effective drugs are available due its elusive mechanisms. Our previous clinical studies found that surgical removal or radiofrequency treatment of the neuroma at axotomized nerve stump effectively relieves phantom afflicting patients after amputation. This indicated an essential role residual in formation chronic post-amputation (CPAP). However, molecular mechanism by which is involved and regulates CPAP a mystery. In this...
Renal ischemia/reperfusion injury is a major contributor of acute kidney (AKI), leading to renal cell necrosis, apoptosis, and inflammation. Calpains, family Ca2+-dependent cysteine proteases, play pivotal role in the pathogenesis diseases. Several studies have reported calpain inhibitors showing remarkable reno-protective effects against proteinuria α-klotho deficiency-induced aging symptoms, particularly glomerulus injury. However, little known about inhibitor calpeptin The present study...
Background: Esophageal squamous cell carcinoma (ESCC), a gastrointestinal cancer, is associated with poor prognosis.Prognostic models predict the likelihood of disease progression and patient survival are important for management patients ESCC.The objective this study was to develop prognostic model ESCC using bioinformatics analyses.Methods: Two transcriptome microarray Gene Expression Omnibus datasets (GSE53624 GSE53622) were analyzed methods.Differentially expressed genes (DEGs)...
Introduction: The concept of magnetic compression technique (MCT) has been accepted by surgeons to solve a variety surgical problems. In this study, we attempted explore the feasibility splenorenal shunt using MCT in canine and cadaver.Material methods: diameters splenic vein (SV), left renal (LRV), vertical interval between them, were measured computer tomography (CT) images obtained from 30 patients with portal hypertension 20 adult cadavers. devices used for then manufactured based on...
Background Knowledge about factors affecting functional disability in patients with non-specific chronic low back pain (NSCLBP) is helpful guiding treatment, but there has been little systematic research on this topic. This study aimed to identify independent contributing NSCLBP especially the impact of sagittal parameters and body postures work, learning, daily life. Methods Sociodemographic data, parameters, Oswestry Disability Index (ODI), Numeric Rating Scale (NRS), 36-item Short Form...
The matter of postoperative radiotherapy (PORT) in esophageal cancer (ESCA) was far from conclusive. Some evidence indicated that lymph node status could affect treatment. We evaluated ratio (LNR) as an indicator be applied to predict PORT benefit.Retrospective cohort study collected the data N1, N2, N3 stage ESCA patients Surveillance, Epidemiology, and End Results database (SEER) analyze association between LNR prognosis 2004 2015. Patients were categorized into two subsets based on...
Objective: To compare the dose, clinical efficacy and acute adverse reactions of intensity modulated radiotherapy (IMRT) three-dimensional conformal (3D-CRT) combined with brachytherapy (3D-BT) in treatment concurrent chemotherapy for advanced stage cervical cancer patients. Methods: Data collection was performed from January 2011 to November 2015 Chinese PLA General Hospital Inner Mongolia Cancer Hospital. All 89 patients (Ⅱ b-Ⅲ b) were treated by pelvic chemotherapy, 46 cases them received...
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To quantify pain pressure threshold(PPT) in the patients with lumbar intervertebral disc herniation before and after treatment, to study clinical effects of PPT test herniation.From January December 2017, 59 hernation were treated, another normal persons recruited as control group. Visual analogue scale (VAS) was used measure patient's subjective intensity at admission, threshold posterior joints measured by tenderness gauge. The three times an interval 1 min most painful contralateral...