A5072037310- Wnt/β-catenin signaling in development and cancer
- Circadian rhythm and melatonin
- Hydrology and Sediment Transport Processes
- Cytokine Signaling Pathways and Interactions
- Ion channel regulation and function
- Psoriasis: Treatment and Pathogenesis
- Hydrology and Watershed Management Studies
- Ion Channels and Receptors
- Flood Risk Assessment and Management
Shanghai Stomatological Hospital
2024
Fudan University
2024
State Key Laboratory of Medical Neurobiology
2024
North China Municipal Engineering Design & Research Institute
2023
Yunnan University of Traditional Chinese Medicine
2022
Thermosensation is vital for the survival, propagation, and adaption of all organisms, but its mechanism not fully understood yet. Here, we find that TMC6, a membrane protein unknown function, highly expressed in dorsal root ganglion (DRG) neurons functions as Gαq-coupled G protein-coupled receptor (GPCR)-like to sense noxious heat. TMC6-deficient mice display substantial impairment heat sensation while maintaining normal perception cold, warmth, touch, mechanical pain. Further studies show...
Urban waterlogging is a natural disaster that occurs in developed cities globally and has inevitably become severe due to urbanization, densification, climate change. The digital elevation model (DEM) an important component of urban risk prediction. However, previous studies generally focused on optimizing hydrological models, there potential improvement DEM by fusing remote sensing data data. To improve the accuracy roads densely built-up areas, multisource fusion approach (MDF-UNet) was...
Psoriasis is a common chronic inflammatory skin disease with multifactor etiology, characterized by abnormal proliferation and differentiation of keratinocytes. Huang-Lian Jie-Du decoction (HLJDD) traditional Chinese medicine prescription good clinical curative effect on psoriasis. However, its therapeutic mechanisms are still unclear.The psoriasis model SKH-1 nude mice was established imiquimod-induced HLJDD gavage given. Hematoxylin eosin staining were used to evaluate pathological...