A5080474994- Geology and Paleoclimatology Research
- Archaeology and ancient environmental studies
- Antimicrobial Peptides and Activities
- vaccines and immunoinformatics approaches
- Pleistocene-Era Hominins and Archaeology
- Pacific and Southeast Asian Studies
- Geological formations and processes
- Genomics, phytochemicals, and oxidative stress
- RNA Interference and Gene Delivery
- Remote Sensing and Land Use
- Maritime and Coastal Archaeology
- RNA and protein synthesis mechanisms
- Advanced biosensing and bioanalysis techniques
- Ion Channels and Receptors
- Biochemical and Structural Characterization
- Protein Structure and Dynamics
- Antifungal resistance and susceptibility
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- HIV Research and Treatment
- Carbohydrate Chemistry and Synthesis
- Bacteriophages and microbial interactions
- Helicobacter pylori-related gastroenterology studies
- interferon and immune responses
- Plant Reproductive Biology
- Viral Infections and Vectors
Tianjin University
2020-2025
Peking University
1989-2024
Central South University
2024
Air Force Medical University
2024
Tianjin Medical University Cancer Institute and Hospital
2024
Army Medical University
2024
Second Military Medical University
2024
The Wallace H. Coulter Department of Biomedical Engineering
2023
Georgia Institute of Technology
2023
Nanjing University
2012-2022
The process of recycling poly(ethylene terephthalate) (PET) remains a major challenge due to the enzymatic degradation high-crystallinity PET (hcPET). Recently, bacterial PET-degrading enzyme, PETase, was found have ability degrade hcPET, but with low activity. Here we present an engineered whole-cell biocatalyst simulate both adsorption and steps in PETase achieve efficient hcPET. Our data shows that adhesive unit hydrophobin are functionally displayed on surface yeast cells. turnover rate...
Aberrant accumulation of misfolded Cu, Zn superoxide dismutase (SOD1) is a hallmark SOD1-associated amyotrophic lateral sclerosis (ALS), an invariably fatal neurodegenerative disease. While recent discovery nonnative trimeric neurotoxicity has suggested potential pathway for motor neuron impairment, it yet unknown whether large, insoluble aggregates are cytotoxic. Here we designed SOD1 mutations that specifically stabilize either the fibrillar form or state SOD1. The mutants display elevated...
Holocene environmental change and archaeology are important components of an international project studying the human-earth interaction system. This paper reviews progress research in Yangtze River Valley over last three decades, that includes evolution large freshwater lakes, transgression sea-level changes, climate East Asian monsoon variation, relationship between rise fall primitive civilizations cultural interruptions palaeoflood events, as well origin agriculture change. These...
The rapid evolution of highly infectious pathogens is a major threat to global public health. In the front line defense against bacteria, fungi, and viruses, antimicrobial peptides (AMPs) are naturally produced by all living organisms offer new possibilities for next-generation antibiotic development. However, low yields difficulties in extraction purification AMPs have hindered their industry scientific research applications. To overcome these barriers, we enabled high expression bomidin,...
Excessive drinking poses serious health risks and is closely associated with oxidative damage. The KEAP1-NRF2-ARE axis serves as the primary antioxidant system. However, existing small molecule inhibitors are all covalently bound to KEAP1, meaning that once bound, they not easily dissociated, while continuous inhibition of KEAP1 exhibits severe side effects. In this study, BLI, CETSA, Pull-down, Co-IP HDX-MS assay analysis were conducted detect binding behavior natural product, capsaicin...
Thermosensation is vital for the survival, propagation, and adaption of all organisms, but its mechanism not fully understood yet. Here, we find that TMC6, a membrane protein unknown function, highly expressed in dorsal root ganglion (DRG) neurons functions as Gαq-coupled G protein-coupled receptor (GPCR)-like to sense noxious heat. TMC6-deficient mice display substantial impairment heat sensation while maintaining normal perception cold, warmth, touch, mechanical pain. Further studies show...
Excessive drinking poses serious health risks and is closely associated with oxidative damage. The KEAP1-NRF2-ARE axis serves as the primary antioxidant system. However, existing small molecule inhibitors are all covalently bound to KEAP1, meaning that once bound, they not easily dissociated, while continuous inhibition of KEAP1 exhibits severe side effects. In this study, BLI, CETSA, Pull-down, Co-IP HDX-MS assay analysis were conducted detect binding behavior natural product, capsaicin...
Antimicrobial peptides (AMPs) are attractive candidates to combat antibiotic resistance for their capability target bio-membranes and restrict a wide range of pathogens. It is daunting challenge discover novel AMPs due sparse distributions in vast peptide universe, especially that demonstrate potencies both bacterial membranes viral envelopes. Here we establish de novo AMP design framework by bridging deep generative module graph-encoding activity regressor. The learns hidden ‘grammars’...
Antimicrobial peptides (AMPs) are attractive candidates to combat antibiotic resistance for their capability target biomembranes and restrict a wide range of pathogens. It is daunting challenge discover novel AMPs due sparse distributions in vast peptide universe, especially that demonstrate potencies both bacterial membranes viral envelopes. Here, we establish de novo AMP design framework by bridging deep generative module graph-encoding activity regressor. The learns hidden ‘grammars’...
Wireless Sensor Networks (WSNs) use distributed nodes for tasks such as environmental monitoring and surveillance. Existing anomaly detection methods fail to fully capture correlations in multi-node, multi-modal time series data, limiting their effectiveness. Additionally, they struggle with small sample scenarios, because do not effectively map features classes. To address these challenges, this paper presents an approach that integrates deep learning metric learning. A framework...
Climatic changes in the Yangtze Delta have played an important role emergence, persistence and collapse of civilization. Archaeological excavations region over many years demonstrated that there are several layers fine sand or organic mud interrupt consecutive culture strata a number Neolithic sites. Continuous biostratigraphical sedimentological records from Maqiao cultural site, Shanghai, suggest units resulted expansion water bodies both by sea‐level fluctuations increased flooding during...
Apoferritin-encapsulated Pt nanoparticles (AFt–Pt) were bio-mimetically prepared by an in situreduction method the unique 8 nm spherical cage of apoferritin. The average size AFt–Pt was 4.3 ± 0.9 nm. structure apoferritin remained intact after loading particles its cavity. Apoferritin coating increased amount internalized HepG2 cells about three times viareceptor-mediated endocytosis. showed greatly improved biocompatibility compared with polyvinylpyrrolidone stabilized (PVP–Pt). More than...
Members of the gasdermin (GSDM) family are critical for inducing programmable pyroptosis by forming pores on cell membrane. GSDMB, GSDMC, GSDMD, and GSDME activated caspases or granzyme, leading to release their autoinhibitory domains. The protease SpeB from group A