A5101502010- Genomics, phytochemicals, and oxidative stress
- Photonic and Optical Devices
- Helicobacter pylori-related gastroenterology studies
- Ion Channels and Receptors
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- interferon and immune responses
- Advanced Fiber Optic Sensors
- Osteoarthritis Treatment and Mechanisms
- Health and Wellbeing Research
- Lower Extremity Biomechanics and Pathologies
- Optical Coatings and Gratings
- Adhesion, Friction, and Surface Interactions
- Viral Infections and Vectors
- Inflammasome and immune disorders
- Total Knee Arthroplasty Outcomes
- IL-33, ST2, and ILC Pathways
- Plant pathogens and resistance mechanisms
- Plasmonic and Surface Plasmon Research
- Viral Infections and Immunology Research
- Bone and Joint Diseases
- Magnetic Field Sensors Techniques
- Soil Geostatistics and Mapping
- Energy, Environment, and Transportation Policies
- Advanced optical system design
- RNA regulation and disease
Tianjin University
2020-2025
Peking University
2022-2024
King University
2024
Xiamen University
2024
Tsinghua University
2013-2023
University Town of Shenzhen
2022-2023
Shaanxi University of Science and Technology
2022
Chongqing Jiaotong University
2022
Jinan University
2020-2021
Zhengzhou University
2009-2021
Nucleotide-binding and oligomerization domain-like receptor (NLR) proteins oligomerize into multiprotein complexes termed inflammasomes when activated. Their autoinhibition mechanism remains poorly defined. Here, we report the crystal structure of mouse NLRC4 in a closed form. The adenosine diphosphate-mediated interaction between central nucleotide-binding domain (NBD) winged-helix (WHD) was critical for stabilizing conformation NLRC4. helical HD2 repressively contacted conserved...
It is widely known that stimulator of interferon genes (STING) can trigger nuclear factor κB (NF-κB) signaling. However, whether and how the NF-κB pathway affects STING signaling remains largely unclear. Here, we report Toll-like receptor (TLR)-, interleukin-1 (IL-1R)-, tumor necrosis (TNFR)-, growth (GF-R)-, protein kinase C (PKC)-mediated activation dramatically enhances STING-mediated immune responses. Mechanistically, find interacts with microtubules, which plays a crucial role in...
Cyclic 2',3'-GMP-AMP (cGAMP) binds to and activates stimulator of interferon genes (STING), which then induces interferons drive immune responses against tumors pathogens. Exogenous cGAMP produced by infected malignant cells synthetic used in immunotherapy must traverse the cell membrane activate STING target cells. However, as an anionic hydrophilic molecule, is not inherently permeable. Here, we show that LL-37, a human host defense peptide, can function transporter cGAMP. LL-37...
Excessive drinking poses serious health risks and is closely associated with oxidative damage. The KEAP1-NRF2-ARE axis serves as the primary antioxidant system. However, existing small molecule inhibitors are all covalently bound to KEAP1, meaning that once bound, they not easily dissociated, while continuous inhibition of KEAP1 exhibits severe side effects. In this study, BLI, CETSA, Pull-down, Co-IP HDX-MS assay analysis were conducted detect binding behavior natural product, capsaicin...
Excessive drinking poses serious health risks and is closely associated with oxidative damage. The KEAP1-NRF2-ARE axis serves as the primary antioxidant system. However, existing small molecule inhibitors are all covalently bound to KEAP1, meaning that once bound, they not easily dissociated, while continuous inhibition of KEAP1 exhibits severe side effects. In this study, BLI, CETSA, Pull-down, Co-IP HDX-MS assay analysis were conducted detect binding behavior natural product, capsaicin...
Zinc-air battery has drawn increasing attention from the whole world owing to its large energy capacity, stable working voltage, environmentally friendship and low price. A special porous Zn with three-dimensional (3D) network frame structure, whose multistage average pore sizes can be tuned 300 um 8 um, is synthesized in this work. It found that there a competition between Zn2+ NH4+ for their reduction on supports. And decrease of concentration increase facilitate size. Potential-dynamic...
The objective of this study is to delineate disparities between patients with knee osteoarthritis (KOA) based on obesity status, investigate the interplay among body composition, physical activity and pain/function in KOA conduct subgroup analyses focusing those obesity. Cross-sectional study. Residents eight communities Shijiazhuang, Hebei Province, China, were surveyed from March 2021 November 2021. 178 symptomatic aged 40 years or older included. primary outcome measure was pain, assessed...
Human enterovirus D68 (EV-D68) has received considerable attention recently as a global reemergent pathogen because it causes severe respiratory tract infections and acute flaccid myelitis (AFM). The nonstructural protein 2A protease (2Apro) of EVs, which functions in the cleavage host proteins, comprises pivotal part viral immune evasion process. However, pathogenic mechanism EV-D68 is not fully understood. In this study, we found that inhibited antiviral type I interferon responses by...
Soil contamination by heavy metals is of great concern due to the increasing intensity anthropogenic activities and requires a reliable approach rapidly diagnose metal pollution in soils. In this study conducted northern Shandong Province, China, total 110 soil samples were collected determine zinc concentration their visible near-infrared reflectance spectroscopy was applied contaminated Pearson's correlation analysis competitive adaptive reweighted sampling algorithm compared select active...
Most existing multi-channel spectrometers are constructed by physically stacking single-channel spectrometers, resulting in their large size, high weight, and limited number of channels. Therefore, miniaturization is urgently needed. In this paper, a microlens array grating designed for miniature spectrometers. A transmissive element integrating arrays gratings, the MLAG, enables simultaneous focusing dispersion. Using soft lithography, MLAG was fabricated with deviation less than 2.2%. The...
An optical microfiber interferometric biosensor for the low concentration detection of sequence-specific deoxyribonucleic acid (DNA) based on signal amplification technology via oligonucleotides linked to gold nanoparticles (Au-NPs) is proposed and experimentally analyzed. The sensor uses a “sandwich” strategy, in which capture probe DNA (DNA-c) immobilized surface interferometer, reporter (DNA-r) Au-NPs, DNA-c DNA-r are hybridized target (DNA-t) sandwich arrangement. dynamic DNA-t was found...
Abstract Background Pain is linked to disability, but how multisite musculoskeletal pain leads disability over time not well elaborated. Objective To examine the associations of with among a nationally representative cohort. Design We used data from National Health and Aging Trends Study (NHATS) 2015-22. Disability was assessed by basic activities daily living (ADL) instrumental (IADL). Participants A total 5557 individuals dwelling in community were included this study. Methods Group-based...
Abstract High sensitivity is crucial for anisotropic magnetoresistive (AMR) sensors in industrial applications. In this paper, a high- sensitive AMR sensor based on thin films with Ta/NiFe/Ta/Al four-layer structure proposed and fabricated. Firstly, the structural parameters were optimized by finite element analysis. Secondly, film samples prepared. Through analysis characterization of reluctance change rate, hysteresis loop, x-ray diffraction surface morphology structure, process optimized....
Excessive drinking poses serious health risks and is closely associated with oxidative damage. The KEAP1-NRF2-ARE axis serves as the primary antioxidant system. However, existing small molecule inhibitors are all covalently bound to KEAP1, meaning that once bound, they not easily dissociated, while continuous inhibition of KEAP1 exhibits severe side effects. In this study, BLI, CETSA, Pull-down, Co-IP HDX-MS assay analysis were conducted detect binding behavior natural product, capsaicin...
Excessive drinking poses serious health risks and is closely associated with oxidative damage. The KEAP1-NRF2-ARE axis serves as the primary antioxidant system. However, existing small molecule inhibitors are all covalently bound to KEAP1, meaning that once bound, they not easily dissociated, while continuous inhibition of KEAP1 exhibits severe side effects. In this study, BLI, CETSA, Pull-down, Co-IP HDX-MS assay analysis were conducted detect binding behavior natural product, capsaicin...
The depressive symptom trajectories of COPD individuals and its' predictors remain to be established. Therefore, this study aimed explore the symptoms thereof in patients.
Reasonable carbon market price prediction can facilitate the participants, such as physical producers, to achieve goal of efficient emission reduction through mechanism. In this paper, we use XGBoost, an integrated algorithm in machine learning, forecast domestic from 2013 2021. Pearson coefficient is utilized calculate correlation data features, and perform PCA dimensionality on features with high coefficients. Before using reduce dimensions, order make feature more suitable for later model...