A5054471450- Viral Infections and Immunology Research
- Animal Disease Management and Epidemiology
- Animal Virus Infections Studies
- Virus-based gene therapy research
- Viral gastroenteritis research and epidemiology
- Vector-Borne Animal Diseases
- Viral Infectious Diseases and Gene Expression in Insects
- Plant Virus Research Studies
- Viral Infections and Vectors
- RNA Interference and Gene Delivery
- Cancer-related molecular mechanisms research
- Genetic and phenotypic traits in livestock
- CRISPR and Genetic Engineering
- Genetic Mapping and Diversity in Plants and Animals
- interferon and immune responses
- Inflammasome and immune disorders
- Hydrogels: synthesis, properties, applications
- Animal Nutrition and Physiology
- Reproductive tract infections research
- Advanced Materials and Mechanics
- Immune Response and Inflammation
- SARS-CoV-2 and COVID-19 Research
- Meat and Animal Product Quality
- Streptococcal Infections and Treatments
- Essential Oils and Antimicrobial Activity
Chinese Academy of Agricultural Sciences
2016-2025
Harbin Veterinary Research Institute
2016-2025
Chongqing Academy of Animal Science
2021-2025
Hetao College
2022-2025
Nanjing Agricultural University
2023
Fujian Medical University
2021
Jiangxi University of Finance and Economics
2021
Capital Medical University
2020
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2018
Heilongjiang University of Chinese Medicine
2017-2018
ABSTRACT Mutagenic nucleoside analogues can be used to isolate RNA virus high-fidelity RNA-dependent polymerase (RdRp) variants, the majority of which are attenuated in vivo . However, foot-and-mouth disease (FMDV) RdRp variants have not been isolated, and correlations between fidelity virulence remain unclear. Here, mutagen ribavirin was select a ribavirin-resistant population FMDV, 4 amino acid substitutions (D5N, A38V, M194I, M296V) were identified RdRp-coding region population. Through...
Porcine reproductive and respiratory syndrome (PRRS) is one of the most economically important diseases affecting pig-raising industry. The PRRS virus (PRRSV) has high genetic diversity, partly owing to viral recombination. Some individual recombinant type 2 PRRSV (PRRSV-2) strains have been detected; however, sequence composition characteristics recombination hot spots potential driving forces for PRRSV-2 are still unreported. Therefore, all available genomic sequences (n = 949, including...
RNA viruses cause numerous infectious diseases in humans and animals. The crosstalk between the innate DNA sensing pathways attracts increasing attention. Recent studies showed that cGAS-STING pathway plays an important role restricting via mitochondria (mtDNA) mediated activation. However, mechanisms of cGAS immune evasion by remain unknown. Here, we report seneca valley virus (SVV) protease 3C disrupts mtDNA cleaving porcine (pcGAS) a species-specific manner. Mechanistically, W/Q motif...
Multi-omics has helped elucidate the gene expression patterns and genomic variations closely associated with economically significant traits in geese. Despite substantial data generated through extensive goose studies, a unified platform for integrating these datasets is lacking. To address this gap, we introduced Goose Database (GMD), which accessible at http://goosedb.com/. The GMD comprehensive resource enabling streamlined search, analysis, visualization of genetic information interface,...
To explore the impact of epigenetic modifications on egg-laying traits in geese, we employed genome-wide bisulfite sequencing (WGBS) to analyze DNA methylation patterns pituitary tissues high-(HYP) and low-yield (LYP) Sichuan White geese. We achieved high-quality data (mean 19.09 Gb raw reads, 15.49 clean 79.1% unique mapping rate) with a conversion efficiency 99.88%. Comparative analysis revealed 2394 differentially methylated regions (DMRs) 422 genes (DMGs) between HYP LYP groups....
ABSTRACT Nuclear cyclic GMP-AMP synthetase (cGAS) binds to nucleosome with high affinity prevent its activation by self-DNA. Upon stimulation double-stranded DNA, cGAS is activated and translocates from the nucleus cytoplasm, guided N-terminal domain. However, it remains unclear whether viruses can hijack translocation regulate activation. Here, we discovered that protease 3C of picornavirus Seneca Valley virus (SVV) cytoplasm upon viral infection nuclear DNA. Protease specifically cleaves...
Abstract Sunflower ( Helianthus annuus L.), a dominant crop in Hetao Irrigation District, Western Inner Mongolia, is cultivated arid and saline‐alkaline fields due to their salt alkali tolerance, ensuring that farmers’ income from these not lower than those fertile lands. However, little known about the integrated analysis of nitrogen (N) dynamics, including soil total N (TN), nitrate (NO 3 − ), leachate TN NO , nitrous oxide (N 2 O) fluxes, cycling microbial gene abundance sunflower fields....
Porcine reproductive and respiratory syndrome virus (PRRSV) is a significant infectious disease impacting the global swine industry. Due to high frequency of viral mutation recombination, PRRSV exhibits complex genetic diversity; however, its lineage classification, restriction fragment length polymorphism (RFLP) patterns, spatiotemporal distribution have not been systematically analyzed in China. In this study, we sequenced PRRSV‐2 open reading frame (ORF)5 sequences from clinical samples (...
Senecavirus A (SVA) is a reemerging virus, and recent evidence has emphasized the importance of SVA recombination
Cap-independent translation initiation on picornavirus mRNAs is mediated by an internal ribosomal entry site (IRES) in the 5' untranslated region. The regulation of requires interaction IRES-transacting factors (ITAFs) with IRES. In this study, we identified a novel ITAF, heterogeneous nuclear ribonucleoprotein K (hnRNP K), which negatively regulates foot-and-mouth disease virus (FMDV) and viral replication. Further investigation revealed that KH2 KH3 domains hnRNP directly bind to II, III,...
Members of the gasdermin (GSDM) family are critical for inducing programmable pyroptosis by forming pores on cell membrane. GSDMB, GSDMC, GSDMD, and GSDME activated caspases or granzyme, leading to release their autoinhibitory domains. The protease SpeB from group A
Bread wheat is a highly adaptable food crop grown extensively around the world and its quality genetic improvement has received wide attention. In this study, loci associated with five traits including protein content (PC), gluten (GC), baking value (BV), grain hardness (HA), sedimentation (SV) in population of 253 Chinese Inner Mongolia were investigated through genome association mapping. A total 103 QTL containing 556 SNPs significantly related to based on phenotypic data collected from...
The genetic regulation of goose meat quality traits remains relatively unexplored, and the underlying mechanisms are yet to be elucidated. This study aims employ single nucleotide polymorphism (SNP) genotyping in conjunction with genome-wide association studies (GWAS) investigate critical candidate regions genes associated pH trait Sichuan white geese. A cohort 203 healthy male geese was randomly selected slaughtered at 70 days age. Measurements were taken pH, growth parameters, body...
Upon infection, the highly structured 5' untranslated region (5' UTR) of picornavirus is involved in viral protein translation and RNA synthesis. As a critical element UTR, internal ribosome entry site (IRES) binds to various cellular proteins function processes replication. Foot-and-mouth disease virus (FMDV) an important member family Picornaviridae, its UTR contains functional IRES element. In this study, heterogeneous nuclear ribonucleoprotein L (hnRNP L) was identified as IRES-binding...