A5100320503- Ovarian cancer diagnosis and treatment
- Parkinson's Disease Mechanisms and Treatments
- Cancer Mechanisms and Therapy
- Toxin Mechanisms and Immunotoxins
- Alzheimer's disease research and treatments
- Pain Mechanisms and Treatments
- Osteoarthritis Treatment and Mechanisms
- Pulmonary Hypertension Research and Treatments
- Obstructive Sleep Apnea Research
- Bacterial Infections and Vaccines
- Neurological disorders and treatments
- Thyroid Disorders and Treatments
- Body Composition Measurement Techniques
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Inflammasome and immune disorders
- Advanced Breast Cancer Therapies
- Ovarian function and disorders
- Nutrition and Health in Aging
- Nitric Oxide and Endothelin Effects
- Neurological Disease Mechanisms and Treatments
- Telomeres, Telomerase, and Senescence
- Thermoregulation and physiological responses
- Dementia and Cognitive Impairment Research
- Exercise and Physiological Responses
- Nasal Surgery and Airway Studies
Fudan University Shanghai Cancer Center
2024
Shandong University
2024
Shandong First Medical University
2023
Academy of Medical Sciences
2023
TianjinSino-German University of Applied Sciences
2023
Tianjin Huanhu Hospital
2022-2023
State Key Laboratory of Medical Neurobiology
2022
Lanzhou University Second Hospital
2022
Fudan University
2022
First Affiliated Hospital Zhejiang University
2022
Diabetic neuropathic pain (DNP) is a common and devastating complication in patients with diabetes. The mechanisms mediating DNP are not completely elucidated, effective treatments lacking. A-fiber sensory neurons have been shown to mediate the development of mechanical allodynia pain, yet molecular basis underlying contribution still unclear. Here, we report that orphan G protein-coupled receptor 177 (GPR177) drives via WNT5a-mediated activation transient potential vanilloid receptor-1...
Blood brain barrier (BBB) breakdown is considered a potential mechanism of dementia. The Alzheimer's disease (AD) biomarkers and vascular factors are also associated with BBB permeability.In the present study, combination effects neuropathological AD chronic risk for were investigated.The cerebrospinal fluid (CSF)/serum albumin ratio (Qalb), an indicator permeability, was measured in total 95 hospitalized dementia patients. demographics, clinical information, laboratory tests collected from...
With the outbreak of COVID-19, a large number medical staffs have invested in front line anti-epidemic. Medical protective clothing (MPC) can provide safe environment for wearers to block bacteria and viruses. However, nowadays, thermal performance MPC on market is very poor, resulting extremely low comfort wearer. Some improved MPCs were made materials, which not easy obtain with high cost. lack experimental data based real human body. Therefore, this paper proposed novel reusable PCM...
Neoadjuvant chemotherapy may be considered for patients with ovarian cancer (OC) whose tumors are deemed unlikely to completely cytoreduced no gross residual disease (R0) or who poor surgical candidates. This Ib/II study was designed assess the efficacy and safety of nanoparticle albumin-bound paclitaxel (nab-paclitaxel) plus carboplatin as neoadjuvant stages III–IV, unresectable OC. Eligible stage OC were enrolled in this phase study. All received nab-paclitaxel (260 mg/m2, day 1, every 3...
Post-amputation pain causes great suffering to amputees, but still no effective drugs are available due its elusive mechanisms. Our previous clinical studies found that surgical removal or radiofrequency treatment of the neuroma at axotomized nerve stump effectively relieves phantom afflicting patients after amputation. This indicated an essential role residual in formation chronic post-amputation (CPAP). However, molecular mechanism by which is involved and regulates CPAP a mystery. In this...
Dementia with Lewy bodies (DLB) is the second most common neurodegenerative dementia. Although DLB characterized by fluctuating cognitive impairment, some symptoms may appear before including rapid eye movement, sleep behavior disorder (RBD), psychiatric symptoms, autonomic Parkinson's etc. Therefore, be misdiagnosed as other diseases in its early stage. This study aimed to investigate characteristics of initial DLB, which could potentially offer essential clues for earliest diagnosis this...
Abstract This study aimed to evaluate whether there is a causal relationship between autoimmune thyroid disorders (AITDs) and telomere length (TL) in the European population reverse causality. In this study, Mendelian randomization (MR) colocalization analysis were conducted assess potential AITDs TL using summary statistics from large‐scale genome‐wide association studies, followed by of stimulating hormone free thyroxine (FT4) help interpret findings. The inverse variance weighted (IVW)...
Hydration of fat-free mass (FFM), defined as the ratio total body water (TBW) to FFM (TBW/FFM), is stable at 0.739 in adult mammals. However, an increase TBW/FFM common hemodialysis (HD) patients. This study aimed evaluate determinants and investigate its predictive value for prognosis all-cause mortality HD We enrolled patients undergoing maintenance between July 2020 May 2021. All were prospectively followed until death, dropout, or end (November 1, 2021). A forward stepwise multivariable...
Nitric oxide (NO) is crucial for the progression of early diabetic nephropathy (DN). It important to clarify mechanism production NO in mesangial cells (MCs). In this study, amounts/activities related factors such as reactive oxygen species (ROS), NO, 3 isoforms nitric synthase (NOS), tetrahydrobiopterin (BH4), GTP cyclohydrolase I (GTPCH I), Jak2, and Stat1 were determined using high-glucose cultured rat MCs. The results showed that BH4 under oxidative stress was strongly stimulated by its...
Objective To evaluate the application of time to positivity (TTP) in differential diagnosis intracranial infection caused by coagulase-negative Staphylococcus (CNS). Methods One hundred and twenty-four adult patients with positive CNS isolated from cerebrospinal fluid (CSF) including 70 cases 54 CSF contamination, who were admitted Xiangya Hospital Central South University during January December 2015, retrospectively analyzed. The difference TTP between two groups was compared,...
Abstract Background Resolvin D1 could reduce the inflammatory, catabolic response of OA chondrocyte, and promote repair various tissues.Our goal was to explore whether RvD1 inhibit NLRP3/caspase-1 signaling pathway, slow down occurrence pyroptosis chondrocytes, then proliferation chondrocytes articular cartilage. Methods Animal care use protocols comply with National Institutes Health Guide for Care Use Laboratory Animals.After rat osteoarthritis model established, injected a control group...