A5101668491- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Reproductive System and Pregnancy
- Intraperitoneal and Appendiceal Malignancies
- Endometriosis Research and Treatment
- Cancer Mechanisms and Therapy
- Chromatin Remodeling and Cancer
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Plant biochemistry and biosynthesis
- Cervical Cancer and HPV Research
- Immune Cell Function and Interaction
- Ginseng Biological Effects and Applications
- Glycosylation and Glycoproteins Research
- Toxin Mechanisms and Immunotoxins
- Inflammatory Biomarkers in Disease Prognosis
- Natural product bioactivities and synthesis
- Cancer Immunotherapy and Biomarkers
- Blood Coagulation and Thrombosis Mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Venous Thromboembolism Diagnosis and Management
- Immunotherapy and Immune Responses
- Polysaccharides and Plant Cell Walls
- Renal cell carcinoma treatment
- Cancer survivorship and care
Fudan University Shanghai Cancer Center
2016-2025
Shanghai Medical College of Fudan University
2018-2025
Ningbo Medical Center Lihuili Hospital
2014-2024
Ningbo University
2024
Yunnan Agricultural University
2019-2023
Tarim University
2022
Fudan University
2013-2020
Minhang District Central Hospital
2020
Sun Yat-sen University
2015-2020
ORCID
2020
Abstract Background N6‐methyladenosine (m 6 A) RNA modification has been demonstrated to be a significant regulatory process in the progression of various tumors, including breast cancer. Fat mass and obesity‐associated (FTO) enzyme, initially known as obesity‐related protein, is first identified m A demethylase. However, relationship between FTO cancer remains controversial. In this study, we aimed elucidate role clinical significance explore underlying mechanism. Methods We investigated...
Alterations in peripheral blood lymphocytes cervical cancer have been reported, although conflicting views exist. The present study investigated the distributions of lymphocyte subsets tumor tissue and samples from patients precancerous lesion patients, evaluated correlations with clinicopathological prognostic variables.A total 44 stage IB1-IIA2 13 were included. Lymphocytes collected blood, isolated by Lymphoprep density gradient centrifugation. percentages quantified flow cytometry...
Gene duplication is assumed to be the major force driving evolution of metabolite biosynthesis in plants. Freed from functional burdens, duplicated genes can mutate toward novelties until fixed due selective fitness. However, extent which this mechanism has driven diversification remains tested. Here we performed comparative genomics analysis and characterization evaluate impact gene on triterpenoid using Panax species as models. We found that whole-genome duplications (WGDs) occurred...
Abstract In recent decades, antibodies have emerged as indispensable therapeutics for combating diseases, particularly viral infections. However, their development has been hindered by limited structural information and labor-intensive engineering processes. Fortunately, significant advancements in deep learning methods facilitated the precise prediction of protein structure function leveraging co-evolution from homologous proteins. Despite these advances, predicting conformation remains...
To assess the utility of TCGA molecular classification endometrial cancer in a well-annotated, moderately sized, consecutive cohort Chinese patients with ovarian clear cell carcinoma (OCCC). We performed DNA sequencing on 80 OCCC via panel that contains 520 cancer-related genes. The subtyping method was utilized for classification. clinicopathological features were analysed, and survival correlation assessed each subtype. most common mutated genes ARID1A (49%) PIK3CA (48%). No pathogenic...
It has long been appreciated that different subtypes (serous, clear cell, endometrioid and mucinous) of epithelial ovarian carcinoma (EOC) have distinct pathogenetic pathways. However, clinical management, especially chemotherapeutic regimens, for EOC patients is not subtype specific. Ovarian cell (CCC) a rare histological EOC, which exhibits high rates recurrence low chemosensitivity. We assessed potential therapeutic targets CCC through analyzing the variation drug-based molecular...
Abstract Background Taproot thickening is a complex biological process that dependent on the coordinated expression of genes controlled by both environmental and developmental factors. Panax notoginseng an important Chinese medicinal herb characterized enlarged taproot as main organ saponin accumulation. However, molecular mechanisms enlargement are poorly understood. Results A total 29,957 differentially expressed (DEGs) were identified during in taproots P. notoginseng. Gene Ontology Kyoto...
Abstract Background We performed an integrative genomic and transcriptomic profiling to identify molecular subtypes prognostic markers with special focus on immune-related pathways. Methods Totally, 50 Chinese patients were subjected targeted next-generation sequencing sequencing. Results Two distinct subgroups identified as immune (22.0%) non-immune (78.0%) based the immune-pathway related hierarchical clustering. Surprisingly, subtype had a significantly worse survival. The capacity was...
Abstract Background This study aims to evaluate the role of fibrinogen/albumin ratio (FAR) in predicting platinum resistance and survival outcomes patients with ovarian clear cell carcinoma (OCCC). Methods Coagulation function D-dimer, serum albumin, CA125 HE4 levels were measured before surgery OCCC undergoing initial our institution. FAR was calculated as level. The correlation between these indicators clinicopathological features, response, further analyzed. Kaplan-Meier method...
Purpose To profile the characteristic and prognostic implications of venous thromboembolism (VTE) in Chinese ovarian clear cell carcinoma (CCC) patients. Methods We identified all cases between 2000 2012 by searching our institutional Ovarian CCC Database. A comprehensive review medical documentation was performed to collect relevant data. Kaplan-Meier models Cox regression were employed for survival analysis. Results Of 227 patients, 33 (14.5%) experienced VTE events. There no significant...
Ovarian clear cell carcinoma (CCC) is a distinct histologic subtype with relatively poor survival. No prognostic or predictive molecular marker currently available. Recent studies have shown that AT-rich interactive domain 1A (ARID1A) and phosphatidylinositol 3-kinase catalytic subunit alpha (PIK3CA) mutations are common genetic changes in ovarian CCC. Hepatocyte nuclear factor-1β (HNF-1β) expression has been proven to be highly sensitive specific for histology. However, the correlations...
Regulatory T cells (Tregs) are crucial for the maintenance of peripheral tolerance, but they also limit beneficial responses through cancer‐induced immunoediting. The roles Treg subsets in cervical squamous cell carcinoma (CSCC) currently unknown. Here, we aimed to perform an extensive study with increased resolution compartment blood and tumor tissues CSCC patients. We first identified that HLADR hi population was significantly patients compared precancer healthy donors. found Tregs express...
Abstract Background This study attempts to evaluate whether preoperative systemic inflammatory response (SIR) markers or other hematological variables, such as albumin, D-dimer, and carbohydrate antigen 125, play roles in predicting chemotherapy survival outcome patients with ovarian clear cell carcinoma (OCCC). Methods Preoperative leukocyte differential counts, well platelet, serum plasma D-dimer CA-125 levels, were measured FIGO IC-IV cancer. The correlations of these biomarkers...
-
There is a special interaction between the environment, soil microorganisms, and tea plants, which constitute ecosystem of plantations. Influenced by environmental factors human management, changes in microbial community affected growth, quality, yield plants. However, little known about composition structure bacterial fungal communities 100-year-old plantations mechanisms they are affected. In this regard, we characterized microbiome plantation soils considering 448 samples from 101 ancient...
Purpose: With widespread use of ionizing radiation, more attention has been attracted to low-dose radiation (LDR); however, the mechanisms long-term LDR-induced bio-effects are unclear. Here, we applied human B lymphoblast cell line HMy2.CIR monitor effects LDR and potential involvement DNA methylation.Materials methods: cells were irradiated with 0.032 Gy γ-rays three times per week for 1–4 weeks. Some these primed further challenged 2 γ-rays. Cell proliferation, micronuclei formation, gene...