A5100455876- Neurobiology and Insect Physiology Research
- Erythrocyte Function and Pathophysiology
- Cellular transport and secretion
- Insect Utilization and Effects
- Invertebrate Immune Response Mechanisms
- Telomeres, Telomerase, and Senescence
- Ion Channels and Receptors
- Cancer-related molecular mechanisms research
- Microtubule and mitosis dynamics
- Ion channel regulation and function
- Alzheimer's disease research and treatments
- Asthma and respiratory diseases
- Nerve injury and regeneration
- Pelvic and Acetabular Injuries
- Lysosomal Storage Disorders Research
- Biomedical Ethics and Regulation
- Frailty in Older Adults
- Clinical Laboratory Practices and Quality Control
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- High Altitude and Hypoxia
- Vascular Tumors and Angiosarcomas
- Venomous Animal Envenomation and Studies
- Genetics, Aging, and Longevity in Model Organisms
- Extracellular vesicles in disease
- Tuberous Sclerosis Complex Research
AbbVie (United States)
2025
Taipei Veterans General Hospital
2024
University of California, San Francisco
2011-2024
Wuhan University
2024
University of Massachusetts Chan Medical School
2018-2023
Jiangxi University of Traditional Chinese Medicine
2023
Shanghai Jinyuan Senior High School
2023
First Affiliated Hospital of Henan University of Science and Technology
2023
China Astronaut Research and Training Center
2022
Yuncheng University
2022
At the cellular level, α-tubulin acetylation alters structure of microtubules to render them mechanically resistant compressive forces. How this biochemical property microtubule relates mechanosensation remains unknown, although prior studies have shown that influences touch perception. Here, we identify major Drosophila acetylase (dTAT) and show it plays key roles in several forms mechanosensation. dTAT is highly expressed larval peripheral nervous system (PNS), but largely dispensable for...
PU.1 transcription factor is a critical regulator of hematopoiesis and leukemogenesis. Because interacts with factors GATA-2 C/EBPalpha, both are involved in the regulation adipogenesis, we investigated whether plays role adipocyte differentiation. Our data indicate that expressed white adipose tissue. protein can also be detected cultured 3T3-L1 adipocytes. Forced expression cells inhibits differentiation, whereas deletion transactivation domain abolishes this effect. The inhibition...
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease characterized by repetitive alveolar injuries with excessive deposition of extracellular matrix (ECM) proteins. A crucial need in understanding IPF pathogenesis identifying cell types associated histopathological regions, particularly local centers known as fibroblast foci. To address this, we integrated published spatial transcriptomics and single-cell RNA sequencing (scRNA-seq) adopted the Query method Overlap to determine...
Acute nociception is essential for survival by warning organisms against potential dangers, whereas tissue injury results in a nociceptive hypersensitivity state that closely associated with debilitating disease conditions, such as chronic pain. Transient receptor (Trp) ion channels expressed nociceptors detect noxious thermal and chemical stimuli to initiate acute nociception. The existing model suggests under inflammation, the same Trp are sensitized through transcriptional...
Adult stem cells are essential for tissue maintenance and repair. Although genetic pathways controlling adult extensively investigated in various tissues, much less is known about how mechanosensing could regulate growth. Here, we demonstrate that shear stress sensing regulates intestine cell proliferation epithelial number Drosophila . Ca 2+ imaging ex vivo midguts shows stress, but not other mechanical forces, specifically activates enteroendocrine among all types. This activation mediated...
Located at the interface of dentin-pulp complex, odontoblasts are specialized cells responsible for dentin synthesis and nociceptive signal detection in response to external stimuli. Recent studies have shown that mechanosensitive ion channel PIEZO1 is involved bone formation remodeling through influx calcium ions, it abundantly expressed odontoblasts. However, specific role reactionary dentinogenesis underlying mechanisms remain elusive. In this study, we found intense expression plasma...
Dementia with Lewy bodies (DLB) is the second most common neurodegenerative dementia. Although DLB characterized by fluctuating cognitive impairment, some symptoms may appear before including rapid eye movement, sleep behavior disorder (RBD), psychiatric symptoms, autonomic Parkinson's etc. Therefore, be misdiagnosed as other diseases in its early stage. This study aimed to investigate characteristics of initial DLB, which could potentially offer essential clues for earliest diagnosis this...
Abstract Primary Sjögren’s syndrome (pSS) is a chronic inflammatory autoimmune disease, which mainly damages patients’ exocrine glands. Sensitive early diagnostic indicators and effective treatments for pSS are lacking. Using machine learning methods to find markers therapeutic ways of great significance. In our study, first, 1643 differentially expressed genes (DEGs; 737 were upregulated 906 downregulated) ultimately screened out analyzed by Gene Ontology Kyoto Encyclopedia Genes Genomes...
Abstract Objectives Many studies examining 24-hour movement behaviours based on the 24-Hour Movement Guidelines (24HMG) have been published during COVID-19 pandemic. However, no comprehensive reviews summarized and synthesized evidence concerning using 24HMG. The aim of this scoping review was to synthesize from 24HMG Methods Three electronic databases (Web Science, PubMed, EBSCO) were utilized conduct a literature search. search procedure adhered guidelines set by Preferred Reporting Items...
Abstract Objectives Alzheimer's disease (AD) is a well‐known neurodegenerative disease, of which the hallmark disposition β‐amyloid (Aβ) in form plaque brain. Neprilysin (NEP) major enzyme to degrade Aβ and prevent accumulation Aβ. The present study was undertaken elucidate correlation between NEP gene polymorphisms AD Chinese Tibetan population. Methods Ninety‐nine sporadic patients 113 healthy controls were enrolled this study. genotype frequencies allele multiple loci analyzed using...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPyrularia thionin binding to and the role of tryptophan-8 in enhancement phosphatidylserine domains erythrocyte membranesFei Wang, Gary H. Naisbitt, Leo P. Vernon, Michael GlaserCite this: Biochemistry 1993, 32, 46, 12283–12289Publication Date (Print):November 1, 1993Publication History Published online1 May 2002Published inissue 1 November 1993https://doi.org/10.1021/bi00097a003RIGHTS & PERMISSIONSArticle Views52Altmetric-Citations17LEARN ABOUT...
Telomerase reverse transcriptase (TERT) is the protein component of telomerase complex. Evidence has accumulated showing that nontelomeric functions TERT are independent telomere elongation. However, mechanisms governing interaction between and its target genes not clearly revealed. The biological fully elucidated have thus far been underestimated. To further explore these functions, we investigated networks using multiple bioinformatic databases, including BioGRID, STRING, DAVID, GeneCards,...
Frailty is recognized as a cornerstone of geriatric medicine. Accurately screening and identifying frailty can promote better quality personalized medical services for the elderly. Previous studies have shown that association between vitamin D in elderly population still controversial. More research needed to explore them.We used three waves data from National Health Nutrition Examination Survey (NHANES). Based on widely accepted AAH FRAIL Scale, we measured evaluated participants' five...
This study describes the treatment of two patients with recurrent, infected abdominal wall defects using bilateral delayed and tunnelled pedicled tensor fascia lata (TFL) myofascial flaps. TFL flaps were elevated for 4 weeks in both cases. In second case, Parietex Composite mesh was positioned underneath flap allowed to incorporate. After a delay weeks, harvested subcutaneously repair defect. Both have stable repairs but had donor site seromas requiring drainage. Cadaver dissection also...
We investigated the otological aspects of Fabry disease (FD) in patients with normal hearing. Forty-one (21 men, 20 women) bilaterally hearing were recruited, and their symptoms evaluations, which included pure tone audiometry (PTA) distortion product otoacoustic emission (DPOAE), investigated. Ten 21 male (47.6%) eight female (40.0%) had symptoms, tinnitus was most frequent. Cardiac dysfunction more frequently observed patients. The average thresholds on PTA below 25 dB at all frequencies,...