A5051169085- Dental Radiography and Imaging
- Endodontics and Root Canal Treatments
- Dental Research and COVID-19
- Cleft Lip and Palate Research
- Dental Implant Techniques and Outcomes
- Craniofacial Disorders and Treatments
- Oral and Maxillofacial Pathology
- Oral and gingival health research
- Dental Anxiety and Anesthesia Techniques
- Periodontal Regeneration and Treatments
- Oral microbiology and periodontitis research
- COVID-19 diagnosis using AI
- dental development and anomalies
- Hedgehog Signaling Pathway Studies
- Erythrocyte Function and Pathophysiology
- Oral Health Pathology and Treatment
- Dental materials and restorations
- Streptococcal Infections and Treatments
- Surgical Sutures and Adhesives
- COVID-19 Clinical Research Studies
- Electrospun Nanofibers in Biomedical Applications
- Folate and B Vitamins Research
- Cancer Research and Treatments
- Mesenchymal stem cell research
- Infant Nutrition and Health
Wuhan University
2016-2025
Radboud University Nijmegen
2009-2014
Radboud University Medical Center
2009-2014
The epidemic of coronavirus disease 2019 (COVID-19), originating in Wuhan, China, has become a major public health challenge for not only China but also countries around the world. World Health Organization announced that outbreaks novel have constituted emergency international concern. As February 26, 2020, COVID-19 been recognized 34 countries, with total 80,239 laboratory-confirmed cases and 2,700 deaths. Infection control measures are necessary to prevent virus from further spreading...
Non-syndromic cleft lip with palate (NSCLP) is the most serious sub-phenotype of non-syndromic orofacial clefts (NSOFC), which are common craniofacial birth defects in humans. Here we conduct a GWAS NSCLP multiple independent replications, totalling 7,404 NSOFC cases and 16,059 controls from several ethnicities, to identify new risk loci, explore genetic heterogeneity between sub-phenotypes NSOFC. We 41 SNPs within 26 loci that achieve genome-wide significance, 14 novel (RAD54B, TMEM19,...
During a short period of time, the outbreak pneumonia caused by novel coronavirus, named Novel Coronavirus Pneumonia (NCP), was first reported in China, spreading to 24 countries and regions rapidly. The number confirmed cases deaths continued rise. World Health Organization (WHO) announced that outbreaks coronavirus have constituted Public Emergency International Concern. Efficient infection control can prevent virus from further spreading, which makes epidemic situation under control. Due...
Tissue engineering (TE) is critical in oral and craniofacial reconstruction. One of the most popular topics on biomaterial-based tissue regeneration process may be interaction between cells scaffolds. An increasing number studies have identified variables affecting cell-scaffold interaction. The creation investigation new scaffolds for TE regenerative medicine based specific interactions become possible owing to these findings. This review discusses effects various types scaffold materials...
Apical periodontitis (AP) is one of the most prevalent disorders in dentistry. However, it can be underdiagnosed asymptomatic patients. In addition, perioperative evaluation 3-dimensional (3D) lesion volume great clinical relevance, but required slice-by-slice manual delineation method time- and labor-intensive. Here, for quickly accurately detecting segmenting periapical lesions (PALs) associated with AP on cone beam computed tomography (CBCT) images, we proposed geographically validated a...
IntroductionOdontoblasts, terminally differentiated dentin-forming cells with their processes that penetrate into dentin, have been considered potential sensory cells. Current research suggests odontoblasts sense external stimuli and transmit pain signals. PIEZO1, as a specific mechanically activated ion channel, may play an important role in mechanical transduction odontoblasts. In this study, we devoted to investigating the functions underlying molecular mechanisms of PIEZO1 channels...
The rapid advancement of large language models (LLMs) has opened new possibilities for their adoption as evaluative judges. This paper introduces Themis, a fine-tuned LLM judge that delivers sophisticated context-aware evaluations. We provide comprehensive overview the development pipeline highlighting its scenario-dependent evaluation prompts and two novel methods controlled instruction generation. These designs enable Themis to effectively distill skills from teacher models, while...
In the course of embryonic development skeletal elements form either through intramembranous or endochondral ossification. Wnt proteins play diverse roles during vertebrate development. Wnt16 is a key factor in developing long bones, but its exact role craniofacial bone formation remains unclear. This study was initially undertaken to investigate expression mouse embryos. osteoid calvaria, maxilla, and mandible started later than that ALP osteocalcin (OCN), before mineralization suggesting...
Located at the interface of dentin-pulp complex, odontoblasts are specialized cells responsible for dentin synthesis and nociceptive signal detection in response to external stimuli. Recent studies have shown that mechanosensitive ion channel PIEZO1 is involved bone formation remodeling through influx calcium ions, it abundantly expressed odontoblasts. However, specific role reactionary dentinogenesis underlying mechanisms remain elusive. In this study, we found intense expression plasma...
To investigate the effects of vascular endothelial growth factor A (VEGFA) and underlying molecular mechanisms on migration human dental pulp stem cells (hDPSCs).The expression VEGFA in inflammatory tissue lipopolysaccharide (LPS)-stimulated was examined by immunofluorescence staining qRT-PCR. The hDPSCs detected using transwell wound healing assays. activation FAK, PI3K, Akt p38 signalling evaluated Western blot analysis. Silence RNA (siRNA) technology utilized to knockdown VEGFR1 (Flt-1)...