A5100598901- Seismic Waves and Analysis
- Seismology and Earthquake Studies
- Geophysical Methods and Applications
- Methane Hydrates and Related Phenomena
- Geophysics and Gravity Measurements
- Ionosphere and magnetosphere dynamics
- Earthquake Detection and Analysis
- Microfluidic and Capillary Electrophoresis Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Superconducting Materials and Applications
- Astrophysics and Cosmic Phenomena
- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Mass Spectrometry Techniques and Applications
- Microfluidic and Bio-sensing Technologies
- Electrowetting and Microfluidic Technologies
- Analytical Chemistry and Chromatography
- Advanced Proteomics Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Effects and risks of endocrine disrupting chemicals
- Cancer-related molecular mechanisms research
- Cardiac Fibrosis and Remodeling
- Traditional Chinese Medicine Analysis
- Membrane Separation Technologies
- Membrane Separation and Gas Transport
Queen Mary University of London
2025
China Medical University
2012-2024
Xi'an Jiaotong University
2021-2024
Chinese Academy of Agricultural Sciences
2024
Ministry of Agriculture and Rural Affairs
2024
Pacific Northwest National Laboratory
2010-2023
BOE Technology Group (China)
2017-2023
Thermo Fisher Scientific (United States)
2017-2023
Nanjing Tech University
2020-2022
Wuhan University
2020-2022
Sensitive detection of low-abundance proteins in complex biological samples has typically been achieved by immunoassays that use antibodies specific to target proteins; however, de novo development is associated with high costs, long lead times, and failure rates. To address these challenges, we developed an antibody-free strategy involves PRISM (high-pressure, high-resolution separations coupled intelligent selection multiplexing) for sensitive selected reaction monitoring (SRM)–based...
A series of Zn1−xMgxO samples with dopant content ranging from x = 0 to 0.10 were prepared by a novel rheological phase reaction route. All investigated X-ray diffraction, transmission electron microscopy, scanning inductive coupled plasma optical emission spectroscopy, infrared and UV−vis absorption the Barrett−Emmett−-Teller technique. The effects Mg2+ doping in ZnO on electronic structures photogradation methylene blue dye solution experimentally theoretically. exhibit high...
ZnO twin-cones, a new member to the family, were prepared directly by solvothermal method using mixed solution of zinc nitrate and ethanol. The reaction growth mechanisms twin-cones investigated X-ray diffraction, UV–visible spectra, infrared ion trap mass transmission electron microscopy. All as-prepared cones consisted tiny single crystals with lengths several micrometers. With prolonging time from 1.5 h 7 days, twin-cone shape did not change at all, while lattice parameters increased...
This work addresses the chemical nature of catalytic activity X-ray "pure" CoO nanocrystals. All samples were prepared by a solvothermal reaction route. diffraction indicates formation in cubic rock-salt structure, while infrared spectra and magnetic measurements demonstrate coexistence Co 3O 4. Therefore, nanocrystals are unique composite structure with core surrounded an extremely thin 4 surface layer, which is likely consequence passivation from air oxidation at room temperature. The...
A series of Zn(1-x)Co(x)O nanorods with dopant content ranging from x = 0.00 to 0.10 was prepared by a wet chemical method. All samples were investigated x-ray diffraction, transmission electron microscopy, energy-dispersion line mapping analysis, and UV-visible absorption spectroscopy. It found that Co(2+) ions homogeneously substituted for Zn(2+) in ZnO nanorods. Rhodamine B degradation used as probe reaction evaluate the effect doping on photocatalytic performance under UV light visible...
We recently reported an antibody-free targeted protein quantification strategy, termed high-pressure, high-resolution separations with intelligent selection and multiplexing (PRISM), for achieving significantly enhanced sensitivity using selected reaction monitoring (SRM) mass spectrometry. Integrating PRISM front-end IgY14 immunoaffinity depletion, sensitive detection of proteins at 50-100 pg/mL levels in human blood plasma/serum was demonstrated. However, depletion is often associated...
This work demonstrates the utility of high-throughput nanoLC-MS and label-free quantification (LFQ) for sample-limited bottom-up proteomics analysis, including single-cell (SCP). Conditions were optimized on a 50 μm internal diameter (I.D.) column operated at 100 nL/min in direct injection workflow to balance method sensitivity sample throughput from 24 72 samples/day. Multiple data acquisition strategies also evaluated proteome coverage, data-dependent (DDA), wide-window (WWA),...
N6-Methyladenosine (m 6 A) has been reported to play a dynamic role in osteoporosis and bone metabolism.However, whether m A is involved the osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs) remains unclear.Here, we found that methyltransferase-like 3 (METTL3) was up-regulated synchronously with during hPDLSCs.Functionally, lentivirus-mediated knockdown METTL3 hPDLSCs impaired potential.Mechanistic analysis further showed decreased methylation reduced...
This paper proposes a novel Hybrid Electric Propulsion System (HEPS) architecture based on adaptive droop control, comprising Permanent Magnet Synchronous Generator (PMSG), Fuel Cell (FC), and Lithium-ion (Li-ion) battery. The system employs voltage-compensated control strategy integrated with state machine energy management (SMEMS), enabling the three sources to coordinate effectively meet power demands of aircraft efficiently under various operating conditions. includes detailed analysis...
IntroductionOdontoblasts, terminally differentiated dentin-forming cells with their processes that penetrate into dentin, have been considered potential sensory cells. Current research suggests odontoblasts sense external stimuli and transmit pain signals. PIEZO1, as a specific mechanically activated ion channel, may play an important role in mechanical transduction odontoblasts. In this study, we devoted to investigating the functions underlying molecular mechanisms of PIEZO1 channels...
Poly(dimethylsiloxane) (PDMS) is a widely used substrate for microfluidic devices, as it enables facile fabrication and has other distinctive properties. However, applications requiring highly sensitive nanoelectrospray ionization mass spectrometry (nanoESI-MS) detection, the use of PDMS microdevices been hindered by large chemical background in spectra that originates from leaching uncross-linked oligomers contaminants substrate. A more general challenge devices containing monolithically...
An integrated poly(dimethylsiloxane) (PDMS) membrane-based microfluidic emitter for high-performance nanoelectrospray ionization mass spectrometry has been fabricated and evaluated. The ∼100-μm-thick was created by cutting a PDMS membrane that protrudes beyond the bulk substrate. reduced surface area at enhances electric field reduces wetting of electrospray solvent. As such, enables highly stable electrosprays flow rates as low 10 nL/min is compatible with solvents containing large organic...
Ganoderma triterpenes (GTs) are the major secondary metabolites of lucidum, which is a popularly used traditional Chinese medicine for complementary cancer therapy. In present study, systematic isolation, and in silico pharmacological prediction implemented to discover potential anti-cancer active GTs from G. lucidum. Nineteen GTs, three steroids, one cerebroside, thymidine were isolated Six first fruiting bodies including 3β,7β,15β-trihydroxy-11,23-dioxo-lanost-8,16-dien-26-oic acid methyl...
A novel approach to integrating a buffer ion-permeable membrane in poly(glycidyl methacrylate-co-methyl methacrylate) micro electric field gradient focusing (muEFGF) device is described. weir structure on which the was positioned fabricated between separation channel and gradient-generating channel. Before formation of membrane, surface polymeric microdevice treated for covalent bonding membrane. Following modification, prepolymer solution containing poly(ethylene glycol)...