A5001708890- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Neuroscience and Neuropharmacology Research
- Cardiac Ischemia and Reperfusion
- Calpain Protease Function and Regulation
- Membrane Separation Technologies
- Effects and risks of endocrine disrupting chemicals
- Cardiac Fibrosis and Remodeling
- Traditional Chinese Medicine Analysis
- Neuroscience and Neural Engineering
- Wastewater Treatment and Nitrogen Removal
- Receptor Mechanisms and Signaling
- Neuroscience of respiration and sleep
- Estrogen and related hormone effects
- Venomous Animal Envenomation and Studies
- Marine Toxins and Detection Methods
- Signaling Pathways in Disease
- Healthcare and Venom Research
- Circular RNAs in diseases
- Plant-based Medicinal Research
- Viral Infections and Immunology Research
- Sleep and Wakefulness Research
- Virology and Viral Diseases
- Animal Virus Infections Studies
- Glycosylation and Glycoproteins Research
China Medical University
2016-2025
Dalian Maritime University
2022-2024
Chang'an University
2023
Luoyang Institute of Science and Technology
2020-2022
Shenyang Pharmaceutical University
2007-2022
Capital Medical University
2021
Beijing Obstetrics and Gynecology Hospital
2021
China Pharmaceutical University
2008-2018
Southern Medical University
2017
Nanjing General Hospital of Nanjing Military Command
2017
Chemoresistance represents a major obstacle to the treatment of human cancers. Increased DNA repair capacity is one important mechanisms underlying chemoresistance. In silico analysis indicated that YTHDF1, an m6A binding protein, putative tumor promoter in breast cancer. Loss function studies further showed YTHDF1 promotes cancer cell growth vitro and vivo. facilitates S-phase entry, replication damage repair, accordingly knockdown sensitizes cells Adriamycin Cisplatin as well Olaparib,...
<b><i>Objective:</i></b> To investigate the functional-neuroanatomic substrates of word production using signed versus spoken language. <b><i>Methods:</i></b> The authors studied single-word processing with varying input and output modalities in a 38-year-old woman normal hearing speech who had become proficient sign language 8 years before developing intractable epilepsy. Subdural electrocorticography (ECoG) was performed during picture naming reading (visual inputs) repetition (auditory...
The pandemic SARS-CoV-2 has been reported in 123 countries with more than 5,000 patients died from it. However, the original and intermediate hosts of virus remain unknown. In this study, 1,914 serum samples 35 animal species were used for detection SARS-CoV-2-specific antibodies using double-antigen sandwich ELISA after validating its specificity sensitivity. results showed that no detected above which excluded possibility as host SARS-CoV-2. More importantly, companion animals including...
Pseudorabies virus (PRV) belongs to the Herpesviridae family, and is an important veterinary pathogen. Highly pathogenic PRV variants have caused severe epidemics in China since 2011, causing huge economic losses. To tackle epidemics, we identified a panel of mouse monoclonal antibodies (mAbs) against glycoprotein B (gB) that effectively block infection. Among these 15 mAbs, fourteen them entry complement-dependent manner. The remaining one, 1H1 mAb, however can directly neutralize...
Abstract Both tetrodotoxin‐sensitive (TTX‐S) and TTX‐resistant (TTX‐R) voltage‐dependent Na + channels are expressed in the human neuroblastoma cell line NB‐1, but a gene encoding TTX‐R channel has not been identified. In this study, we have cloned cDNA α subunit of NB‐1 cells designated it hNbR1. The longest open reading frame hNbR1 (accession no. AB158469 ) encodes 2016 amino acid residues. Sequence analysis indicated that is highly homologous with cardiac Nav1.5/ SCN5A > 99% identity....
Sepsis often causes diaphragm contractile dysfunction. Endoplasmic reticulum (ER) stress has been implicated in muscle However, it remains unknown if ER occurs the during sepsis. In present study, rats were divided into 4 groups and received placebo or one of three durations endotoxin treatment (24, 48 h 7 days). Isometric force was measured lung wet-to-dry ratio (W/D) calculated. Hematoxylin eosin (H&E) staining tissue performed electron microscopy assessed damage The mRNA protein...