A5069542752- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Cardiovascular and exercise physiology
- Exercise and Physiological Responses
- Obstructive Sleep Apnea Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Immune Response and Inflammation
- Ion channel regulation and function
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Signaling Pathways in Disease
- Ion Transport and Channel Regulation
- Hemodynamic Monitoring and Therapy
- Pharmacy and Medical Practices
- Mycobacterium research and diagnosis
- Cardiac electrophysiology and arrhythmias
- Vitamin C and Antioxidants Research
- Pediatric Pain Management Techniques
- Pleural and Pulmonary Diseases
- Pulmonary Hypertension Research and Treatments
- Ultrasound in Clinical Applications
- Neuroscience of respiration and sleep
- Heme Oxygenase-1 and Carbon Monoxide
- Immune responses and vaccinations
- Thermal Regulation in Medicine
- Endoplasmic Reticulum Stress and Disease
China Medical University
2008-2025
Heilongjiang Center for Tuberculosis Control and Prevention
2020
Objective: To systematically assess diaphragm dysfunction in patients with sepsis. Based on previous findings that excursion and thickening fraction (DTF) significantly decrease septic patients, this study further analyzed the contraction velocity excursion-time index (E-T index) relation to time. Methods: A total of 59 pneumonia-induced sepsis from Shengjing Hospital China Medical University were recruited (sepsis group). Healthy individuals undergoing routine health check-ups during same...
Sepsis often causes diaphragm contractile dysfunction. Endoplasmic reticulum (ER) stress has been implicated in muscle However, it remains unknown if ER occurs the during sepsis. In present study, rats were divided into 4 groups and received placebo or one of three durations endotoxin treatment (24, 48 h 7 days). Isometric force was measured lung wet-to-dry ratio (W/D) calculated. Hematoxylin eosin (H&E) staining tissue performed electron microscopy assessed damage The mRNA protein...
Abstract Information on the interactive effects of methylprednisolone, controlled mechanical ventilation (CMV), and assisted (AMV) diaphragm function is sparse. Sedated rabbits received 2 days CMV, AMV, spontaneous breathing (SB), with either methylprednisolone (MP; 60 mg/kg/day intravenously) or saline. There was also a control group. In vitro force, myofibril ultrastructure, αII‐spectrin proteins, insulin‐like growth factor‐1 (IGF‐1), muscle atrophy F‐box (MAF‐box) mRNA were measured....
Abstract Although diaphragmatic dysfunction is an important indicator of severity illness and poor prognosis in ICU patients, there no convenient practical method to monitor function. This study was designed analyze dynamic by bedside ultrasound septic patients provide quantitative evidence assess diaphragm function systematically. prospective observational conducted from October 2019 January 2021 the Department Respiratory Critical Care Medicine. 74 suffered sepsis were recruited divided...
Obstructive sleep apnea syndrome (OSAS) is an important consequence of chronic intermittent hypoxia (CIH). Astragaloside IV (AS‐IV) exerts multiple protective effects in diverse diseases. However, whether AS‐IV can attenuate CIH‐induced myocardial injury unclear. In this study, rats exposed to CIH were established and treated with for 4 weeks. vitro, H9C2 cardiomyocytes subjected exposure 48 hours. Then the cardiac function, morphology, fibrosis, apoptosis Ca 2+ homeostasis determined assess...
To understand the mechanism underlying regression of cardiac hypertrophy, we investigated pathological changes after isoproterenol (ISO) withdrawal in ISO-induced cardiomyopathy models rats and neonatal cardiomyocytes. Cardiac hypertrophy was induced by two weeks ISO administration; however, did not regress three natural maintenance administration withdrawn (ISO-wdr group). The remaining ISO-wdr group accompanied a sustained increase level phosphorylated Ca2+/calmodulin-dependent protein...
As of February 22, a total 198 confirmed COVID-19 cases were reported in Harbin, Heilongjiang Province, and no new local Harbin over the next 54 days (1).However, on April 9, newly case was with an unknown source infection (2).The patient, 54-year-old male, developed fever March 28 highest recorded temperature at 37.5 ℃.On 7, symptoms worsened included dyspnea, cough, sputum, chest pain, other symptoms, though he did not experience distress, heart palpitations, nausea vomiting, abdominal...
Sepsis often causes diaphragm contractile dysfunction. Dihydropyridine receptors (DHPRα1s and DHPRα1c) ryanodine (RyR1, RyR2, RyR3) are essential for excitation-contraction coupling in striated muscles. However, their expression during sepsis have not been explored.Eight rats received endotoxin, 8 more placebo. After 24 hours, 3) isometric force was measured. The mRNA protein levels of DHPRs RyRs muscles were determined.Sepsis weakened function. DHPRα1s RyR1 significantly lower septic than...
ABSTRACT Introduction Sepsis can cause decreased diaphragmatic contractility. Intracellular calcium as a second messenger is central to However, changes in intracellular concentration ([Ca 2+ ]) and the distribution co‐localization of relevant channels [dihydropyridine receptors, (DHPRα1s) ryanodine receptors (RyR1)] remain unclear during sepsis. In this study we investigated effect changed [Ca ] expression DHPRα1s RyR1 on diaphragm function Methods We measured contractility isolated muscle...