A5075887716- Cutaneous lymphoproliferative disorders research
- Ion channel regulation and function
- Venomous Animal Envenomation and Studies
- Lymphoma Diagnosis and Treatment
- T-cell and Retrovirus Studies
- Immune Response and Inflammation
- Nicotinic Acetylcholine Receptors Study
- Inflammasome and immune disorders
- Genetic factors in colorectal cancer
- Phytochemistry and Bioactivity Studies
- Neuropeptides and Animal Physiology
- Antimicrobial Peptides and Activities
- interferon and immune responses
- RNA modifications and cancer
- Cancer Mechanisms and Therapy
- Molecular Biology Techniques and Applications
- Ethics and Legal Issues in Pediatric Healthcare
- RNA Interference and Gene Delivery
- Peptidase Inhibition and Analysis
- Bone Metabolism and Diseases
- RNA Research and Splicing
- Fungal Biology and Applications
- Ubiquitin and proteasome pathways
- Orthopaedic implants and arthroplasty
- Cancer, Hypoxia, and Metabolism
Guangxi Medical University
2025
First Affiliated Hospital of Soochow University
2025
Huazhong Agricultural University
2024
Huazhong University of Science and Technology
2023-2024
Tongji Hospital
2023-2024
Affiliated Hospital of Qingdao University
2018-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
Wageningen University & Research
2024
Qingdao University
2012-2024
Stomatology Hospital
2024
Abstract This study was designed to identify highly recurrent genetic alterations typical of Sézary syndrome (Sz), an aggressive cutaneous T-cell lymphoma/leukemia, possibly revealing pathogenetic mechanisms and novel therapeutic targets. High-resolution array-based comparative genomic hybridization done on malignant T cells from 20 patients. Expression levels selected biologically relevant genes residing within loci with frequent copy number alteration were measured using quantitative PCR....
Tetrandrine, a bisbenzylisoquinoline alkaloid component of broadly used traditional Chinese medicine, has antitumor effects against some cancers. In our study, we investigated the tetrandrine on human hepatocellular carcinoma (HCC) in vitro and vivo. The results showed that effectively induced apoptosis liver cancer cell dose- time-dependent manner accompanied by alteration morphology, chromatin fragmentation caspase activation. Tetrandrine treatment also intracellular accumulation reactive...
Ensuring companion animal welfare is a top priority for the pet industry and owners alike. The health of pets can be directly effectively improved through diet. Chenpi includes beneficial ingredients with proven anti-inflammatory, antioxidant, immunomodulatory properties. present investigation involved feeding snacks infused powder (CPP) to dogs 42 days examine potential benefits CPP. research evidenced notable increase in serum superoxide dismutase (SOD), catalase (CAT), glutathione...
Data on genome-wide surveys for chromosome aberrations in primary cutaneous T-cell lymphoma (CTCL) are limited.To investigate genetic CTCL.We analysed 18 cases of Sézary syndrome (SS) and 16 mycosis fungoides (MF) by comparative genomic hybridization (CGH) analysis, correlated findings with the results additional conventional cytogenetics, fluorescent situ (FISH) allelotyping studies.CGH analysis showed imbalances (CIs) 19 34 CTCL (56%). The mean +/- SD number CIs per sample was 1.8 2.4,...
Mitochondrial transfer plays an important role in various diseases, and many mitochondrial biological functions can be regulated by HMGB1. To explore the of hepatocellular carcinoma (HCC) its relationship with HMGB1, field emission scanning electron microscopy, immunofluorescence, flow cytometry were used to detect between HCC cells. We found that cells was confirmed using tunnel nanotubes (TNTs). The mitochondria from highly invasive less could enhance migration invasion ability latter....
Activation of T cells induces transcription the interleukin-2 (IL-2) gene. IL-2 expression is regulated through binding factors to multiple sites within enhancer. One such cis-acting element enhancer NFAT-1 (nuclear factor activated cells) site. activity absent in resting but induced upon T-cell activation. The induction can be inhibited by cyclosporin A, potentially accounting for ability A inhibit production cells. We have previously reported that complex composed at least two proteins and...
To investigate genetic alterations in primary cutaneous B-cell lymphomas (PCBCLs), we have analyzed 29 cases of PCBCL. Comparative genomic hybridization showed chromosome imbalances (CIs) 12 (41%). The mean number CIs per sample was 2.05 +/- 2.97, with gains (1.48 2.38) more frequent than losses (0.56 1.40). common regions were 18/18q (50%), 7/7p (42%), 3/3q (33%), 20 1p (25%), 12/12q and 13/13q whereas loss 6q (42%). Among the different subsets PCBCLs, CI seen 50% diffuse large-cell...
Colorectal cancer (CRC) is one of the most common malignant tumors globally, with both incidence and mortality rates remaining high. In recent years, as research on CRC has deepened, significant progress been made in early screening, pathogenesis, treatment strategies. To explore whether genetic loci autosomes affect prognosis immunity CRC, we first obtained overall expression activity all genes autosomal through GSEA analysis. Then, used a consensus clustering algorithm for typing...
Abstract Primary cutaneous CD30+ anaplastic large cell lymphoma (C‐ALCL) represents a distinct clinical subtype of lymphomas. The etiology and underlying molecular pathogenesis C‐ALCL remain unclear. This study aimed to investigate genetic changes in C‐ALCL. Comparative genomic hybridization (CGH) analysis 23 DNA samples from 15 cases identified chromosome imbalances (CI) 10 eight (43%). mean number CI per sample was 2.09 ± 3.86, with gains (2.00 3.85) more common than losses (0.09 0.29)....
Background BCL2 is upregulated in nodal and extranodal B-cell non-Hodgkin's lymphomas, with a consequent antiapoptotic effect. However, loss of has also been noted some malignancies, suggesting different molecular pathogenesis. Objectives To investigate genomic protein expression status to compare the results that JUNB primary cutaneous lymphomas (PCLs). Methods We analysed gene copy number 88 DNA samples from 80 patients PCL consisting Sézary syndrome/mycosis fungoides (SS/MF), lymphoma...
Activator protein 1 (AP‐1) consists of a group transcription factors including the JUN and FOS family proteins with diverse biological functions. This study assessed genomic expression status AP‐1 in primary cutaneous T‐cell lymphoma (CTCL) by using immunohistochemistry (IHC), Affymetrix microarray, real‐time reverse transcriptase‐polymerase chain reaction (RT‐PCR) fluorescent situ hybridization (FISH). IHC showed JUNB tumor cells from 17 33 cases Sezary syndrome (SS) JUND 16 23 mycosis...
Objective . To investigate the absorption property of representative hydrolyzable tannin, namely corilagin, and its hydrolysates gallic acid (GA) ellagic (EA) from Fructus Phyllanthi tannin fraction (PTF) in vitro Methods Caco-2 cells monolayer model was established. Influences PTF on viability were detected with MTT assay. The transport across monolayers examined for different time points, concentrations, secretory directions. inhibitors P-glycoprotein (P-gp), multidrug resistance proteins...