A5102998783- Phytochemicals and Antioxidant Activities
- Phytochemical compounds biological activities
- Natural product bioactivities and synthesis
- Phytochemistry and Bioactivity Studies
- Neurological Disease Mechanisms and Treatments
- Ion Transport and Channel Regulation
- Ginkgo biloba and Cashew Applications
- Lipid metabolism and disorders
- Potassium and Related Disorders
- Fungal Biology and Applications
- Traditional Chinese Medicine Analysis
- Immune cells in cancer
- Cancer-related molecular mechanisms research
- Papaya Research and Applications
- Phytochemistry and Bioactive Compounds
- Plant and Fungal Interactions Research
- Wood and Agarwood Research
- Barrier Structure and Function Studies
- Medicinal Plants and Neuroprotection
- Neonatal Respiratory Health Research
- Ginger and Zingiberaceae research
- Acute Lymphoblastic Leukemia research
- Single-cell and spatial transcriptomics
- Inflammatory mediators and NSAID effects
- Phytochemistry and biological activity of medicinal plants
Children's Hospital of Fudan University
2025
Sichuan University
2024
Shanghai Jiao Tong University
2024
Taipei Veterans General Hospital
2022
Beijing University of Chinese Medicine
2016-2021
Guangzhou Medical University
2021
Second Military Medical University
2021
State Administration of Traditional Chinese Medicine of the People's Republic of China
2020
Guangdong Pharmaceutical University
2019-2020
Danshen, the dried root of Salvia miltiorrhiza Bge., is a widely used commercially available herbal drug, and unstable quality different samples current issue. This study focused on comprehensive systematic method combining fingerprints chemical identification with chemometrics for discrimination assessment Danshen samples. Twenty-five were analyzed by HPLC-PAD HPLC-MSn. Forty-nine components identified characteristic fragmentation regularities summarized further interpretation bioactive...
Ginseng, the root and rhizome of Panax ginseng C. A. Mey., is a famous herbal medicine, its major ginsenosides exert beneficial effects on nonalcoholic fatty liver disease (NAFLD). Due to multicomponent multitarget features ginsenosides, their detailed mechanisms remain unclear. This study aimed explore role NAFLD potential mediated by gut microbiota related molecular processes. C57BL/6J mice were fed high-fat diet (HFD) supplemented or not with ginsenoside extract (GE) for 12 weeks. A...
The genetic etiology and clinical characteristics of neonates with hyperkalemia remain unknown. We aimed to implement early gene sequencing identify causes, optimize treatment improve outcomes in this population. retrospectively studied the who underwent exome or targeted panel from January 1, 2016, December 31, 2023, at Department Neonatology, Children's Hospital Fudan University. Among 3,757 hyperkalemia, approximately 14.08% sequencing. average gestational age was 34.82±3.94 weeks, birth...
The aim of the present study was to establish a new method based on Similarity Analysis (SA), Cluster (CA) and Principal Component (PCA) determine quality different samples Poria cocos (Schw.) Wolf obtained from Yunnan, Hubei, Guizhou, Fujian, Henan, Guangxi, Anhui Sichuan in China. For this purpose 15 habitats were analyzed by HPLC-PAD HPLC-MS(n). Twenty-three compounds detected HPLC-MS(n), which twenty tentatively identified comparing their retention times mass spectrometry data with that...
Objective . To investigate the absorption property of representative hydrolyzable tannin, namely corilagin, and its hydrolysates gallic acid (GA) ellagic (EA) from Fructus Phyllanthi tannin fraction (PTF) in vitro Methods Caco-2 cells monolayer model was established. Influences PTF on viability were detected with MTT assay. The transport across monolayers examined for different time points, concentrations, secretory directions. inhibitors P-glycoprotein (P-gp), multidrug resistance proteins...
Agarwood (Aquilaria malaccensis Lam.) is a resinous material from different geographical locations. The current evaluation of agarwood quality usually based on its physical properties and chemical compounds, yet only few studies have linked with anxiolytic effect, as indicated by characteristic compounds. In this study, using solid-phase microextraction/gas chromatography–time-of-flight mass spectrometry (SPME/GC-TOFMS) multivariate analysis, we found 116 significantly compounds in samples...
Ganoderma triterpenes (GTs) are the major secondary metabolites of lucidum, which is a popularly used traditional Chinese medicine for complementary cancer therapy. In present study, systematic isolation, and in silico pharmacological prediction implemented to discover potential anti-cancer active GTs from G. lucidum. Nineteen GTs, three steroids, one cerebroside, thymidine were isolated Six first fruiting bodies including 3β,7β,15β-trihydroxy-11,23-dioxo-lanost-8,16-dien-26-oic acid methyl...
Phyllanthus emblica L. is widely used in traditional Tibetan medicine for its therapeutic effects on treating liver, kidney, and bladder problems. We have reported that the tannin fraction has a good anti-hepatocellular carcinoma effect, but active ingredients are not clear. This study was to find of using UPLC-MSn network pharmacology. First all, method employed obtain high-resolution mass spectra different components, 110 compounds were obtained. Then pharmacology biomarkers quality...
Ganoderma triterpenes (GTs) are the major secondary metabolites of lucidum, which is a popularly used traditional Chinese medicine for complementary cancer therapy. The present study was to establish fingerprint evaluation system based on Similarity Analysis (SA), Cluster (CA) and Principal Component (PCA) identification quality control G. lucidum. Fifteen samples from provinces Hainan, Neimeng, Shangdong, Jilin, Anhui, Henan, Yunnan, Guangxi Fujian were analyzed by HPLC-PAD HPLC-MSn....
TB-TF inhibited the proliferation and survival of HCC by regulating EGFR signaling pathway modulating immunosuppressive tumor microenvironment.
Nab-paclitaxel (Abraxane), which is a nanoparticle form of albumin-bound paclitaxel, one the standard chemotherapies for pancreatic ductal adenocarcinoma (PDAC). This study determined effect Abraxane in combination with fusion protein, hIL15-ABD, on subcutaneous Panc02 and orthotopic KPC C57BL/6 murine PDAC models. combined hIL15-ABD best suppressed tumour growth produced 40%-60% reduction size KPC, compared to vehicle group. In group, active interferon-γ (IFN-γ)-secreting CD8+ T cells...
Paraplegia caused by spinal cord ischemic injury remains a potential complication of surgical repair thoracoabdominal aortic aneurysms. Studies suggest that cyclooxygenase (COX) contributes to neuronal damage and COX inhibitors may reduce injury. In this study, we examined whether intrathecal pretreatment with ketorolac, nonselective inhibitor, had protective effect against in rats. Rats were randomized receive either normal saline, ketorolac 30 microg, or 60 microg (n = 6 rats per group) 1...
To investigate the biochemical constituents of fruits Terminalia bellerica (Gaertn.) Roxb. (hereafter termed T. bellerica) and estimate anti-cancer activity different polar extracts. rapidly screen identify ethyl acetate (EA) extracts bellerica, ultra performance liquid chromatography-electrospray ionization/mass spectrometry (UPLC-ESI-MSn) was done. The CellTiter-Blue™ cell-viability assay used to ascertain in 10 human cancer cell lines. Forty polyphenols EA extract were characterized...
Abstract Tuberculosis (TB) has one of the highest mortality rates among infectious diseases worldwide. The immune response in host after infection is proposed to contribute significantly progression TB, but specific mechanisms involved remain be elucidated. Single-cell RNA sequencing (scRNA-seq) provides unbiased transcriptome large quantities individual cells, thereby defining biological comprehension cellular heterogeneity and dynamic state cell populations field immunology therefore...