A5034426865- Magnolia and Illicium research
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Mechanisms and Therapy
- Cancer, Lipids, and Metabolism
- Phagocytosis and Immune Regulation
- Pancreatic and Hepatic Oncology Research
- Synthesis and biological activity
- Biological Activity of Diterpenoids and Biflavonoids
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Neuropeptides and Animal Physiology
- Hops Chemistry and Applications
- Phytochemistry and Bioactive Compounds
- Nuclear Receptors and Signaling
- Histone Deacetylase Inhibitors Research
- Synthesis and Biological Evaluation
- Immune Cell Function and Interaction
- Ferroptosis and cancer prognosis
- Hepatocellular Carcinoma Treatment and Prognosis
- Cytokine Signaling Pathways and Interactions
- Nanoplatforms for cancer theranostics
- Pharmacological Receptor Mechanisms and Effects
- Pharmacological Effects of Natural Compounds
- Plant-derived Lignans Synthesis and Bioactivity
- Macrophage Migration Inhibitory Factor
National Yang Ming Chiao Tung University
2021-2025
China Medical University
2020-2022
National Taipei University
2021
Abstract Addressing the challenges of identifying suitable targets and effective delivery strategies is critical in pursuing therapeutic solutions for glioblastoma (GBM). This study focuses on potential microRNA-124 (miR-124), known its tumor-suppressing properties, by investigating ability to target key oncogenic pathways GBM. The results reveal that CDK4 CDK6—cyclin-dependent kinases promote cell cycle progression—are significantly overexpressed GBM brain samples, underscoring their role...
Fluoxetine, an antidepressant, has been indicated to elicit anti-cancer response in hepatocellular carcinoma (HCC) and non-small cell lung cancer (NSCLC) vitro. However, anticancer effect mechanism of fluoxetine HCC NSCLC vivo still needs be elucidated. In this study, we showed efficacy inhibitory on the tumor progression vivo. Tumor growth was significantly inhibited with treatment Fluoxetine obviously decreased expression proliferative, anti-apoptotic, invasion-associated proteins...
Background/Aim: Amentoflavone, an effective compound derived from medicinal plants, has been shown to boost therapeutic efficacy of chemotherapy in non-small cell lung cancer (NSCLC). However, anti-NSCLC effect amentoflavone is ambiguous. The major purpose the present study was verify inhibitory effects NSCLC cells. Materials and Methods: on growth invasion CL-1-5-F4 cells were evaluated by viability assay, flow cytometry, colony formation nuclear factor-kappa B (NF-κB) reporter gene...
Anti-PD-L1 antibody monotherapy shows limited efficacy in a significant proportion of the patients. A common explanation for inefficacy is lack anti-tumor effector cells tumor microenvironment (TME). Recombinant human interleukin-15 (hIL15), potent immune stimulant, has been investigated clinical trial with encouraging results. However, hIL15 constrained by short half-life and relatively unfavorable pharmacokinetics profile. We developed recombinant fusion IL15 protein composed (hIL15)...
Anti-depressants have been reported to own anti-tumor potential types of cancers; however, the role imipramine in non-small cell lung cancer (NSCLC) has not elucidated. Epidermal growth factor receptor (EGFR) was known be one key regulators that control NSCLC progression. Whether EGFR would target for suppressing tumor signaling transduction and results is remaining unclear.We used CL-1-5-F4 cells animal models identify underlying mechanism therapeutic efficacy imipramine. Cytotoxicity,...
Sunitinib is a multikinase inhibitor used to treat patients with advanced renal cell carcinoma (RCC). However, sunitinib toxicity makes it double-edged sword. Potent immune modulation by extends nuclear interactions. To address these issues, there an urgent need for delivery vectors suitable treatment. We developed PEGylated liposomes as precisely target (lipo-sunitinib) RCC tumors. Further investigations, including RNA sequencing (RNA-seq), were performed evaluate transcriptomic changes in...
Osteosarcoma is an aggressive primary malignant bone tumor that occurs in childhood. Although the diagnostic and treatment options have been improved, osteosarcoma confers poor prognosis. Magnolol, active component of Magnoliae officinalis cortex, has widely applied herb medicine shown to multiple pharmacological activities. However, whether magnolol possesses anti-osteosarcoma capacity remains unknown.We examined cytotoxicity, it regulates apoptosis oncogene expression using MTT, flow...
Nab-paclitaxel (Abraxane), which is a nanoparticle form of albumin-bound paclitaxel, one the standard chemotherapies for pancreatic ductal adenocarcinoma (PDAC). This study determined effect Abraxane in combination with fusion protein, hIL15-ABD, on subcutaneous Panc02 and orthotopic KPC C57BL/6 murine PDAC models. combined hIL15-ABD best suppressed tumour growth produced 40%-60% reduction size KPC, compared to vehicle group. In group, active interferon-γ (IFN-γ)-secreting CD8+ T cells...
Hepatocellular carcinoma (HCC) is a primary liver cancer with limited treatment options and poor prognosis. Regorafenib, multi-kinase inhibitor, has shown promise in HCC treatment; however, its efficacy can be enhanced by combining it other agents. 18β-glycyrrhetinic acid (18β-gly) natural compound potential anti-cancer properties.The toxicity mechanism of regorafenib 18β-gly was assessed on Hep3B cells, Huh7 bearing animal model.The combination exhibited synergistic cells model....
Glioblastoma multiforme (GBM) is the most common form of malignant brain tumor, with poor prognosis; efficacy current standard therapy for GBM remains unsatisfactory. Magnolol, an herbal medicine from Magnolia officinalis, exhibited anticancer properties against many types cancers. However, whether magnolol suppresses progression as well its underlying mechanism awaits further investigation. In this study, we used MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) assay,...
Background/Aim: Sorafenib has been reported to show anti-osteosarcoma (anti-OS) efficacy by inhibiting metastasis; however, a phase II trial suggested that further combination with other agents could be necessary achieve permanent remission. Herein, we aimed identify whether amentoflavone, an abundant natural bioflavonoid found in many medicinal plants, can improve the treatment of sorafenib OS. Materials and Methods: Cell viability, metastasis, apoptosis, nuclear translocation NF-κB after...
Cancer cells have a high demand for sugars and express diverse carbohydrate receptors, offering opportunities to improve delivery with multivalent glycopolymer materials. However, effectively delivering glycopolymers tumors while inhibiting cancer cell activity, altering cellular metabolism, reversing tumor-associated macrophage (TAM) polarization overcome immunosuppression remains challenging area of research due the lack reagents capable simultaneously achieving these objectives. Here,...
Abstract Renal cell carcinoma (RCC) is one of the deadliest malignant tumors worldwide. The RCC’s standard treatments are including surgery, radiation, and chemotherapy. SUTENT® (sunitinib) was approved by US Food Drug Administration (FDA) in 2016 to treat advanced RCC. According results from clinical trial, sunitinib associated with a higher objective response rate survival than IFN-α, which indicates that it an effective multiple tyrosine kinase inhibitor (TKi) against Meanwhile, recent...
Abstract Imipramine was known as an anti-depression agent; interestingly, recent studies indicated the potential of various tumors growth inhibition. However, anticancer mechanism imipramine on non-small cell lung cancer (NSCLC) is remaining ambiguous. Thus, aim study to determent effects and underlying human NSCLC CL1-5/F4 cells. MTT assays were used for testing viability imipramine. The activation expression apoptosis, anti-apoptosis, DNA damage, cellular calcium, metastasis-associated...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the hardest medical challenge in world. Nab-paclitaxel significantly more effective chemotherapy drugs than paclitaxel formulated as Cremophor EL. In this study, we reported immune effect Abraxane to combine with our new design recombinant human IL-15 fused albumin binding domain (hIL-15-ABD) on subcutaneously Panc02 and orthotopically KPC PDAC animal models. results, combination treatment greatly reduced subcutaneous tumor growth...
Abstract Hepatocellular carcinoma (HCC) was known as a malignant tumor that has been reported with vascular endothelial growth factor (VEGF) and myeloid cell leukemia 1 (Mcl-1) overexpression. Both VEGF Mcl-1 are the important downstream factors of nuclear kappa-light-chain-enhancer activated B cells (NF-κB) which also to highly associated HCC progression. Regorafenib multi-kinase inhibitor can inhibit part expression in HCC. However, single treatment efficiency regorafenib on still needs be...