Sorafenib is effective for patients with advanced hepatocellular carcinoma (HCC) and particularly those who are unsuitable to receive life-prolonging transarterial chemo-embolization. The survival benefit of sorafenib, however, unsatisfactory. Vorinostat also known as suberoylanilide hydroxamic acid (SAHA) a histone deacetylase (HDAC) inhibitor anti-HCC efficacy in preclinical studies. SAHA induces nuclear factor κ-light-chain-enhancer activated B cells (NF-κB) activity vitro, which may lead...

The persistent activation of the epidermal growth factor receptor (EGFR) leads to downstream oncogenic kinases and transcription factors, resulting in tumor progression an increased resistance cisplatin bladder cancer (BC) cells. Lenvatinib, oral multikinase inhibitor, has potential offer therapeutic benefits as adjuvant treatment for BC patients. investigation into its application is a valuable endeavor. primary goal this study confirm effectiveness mechanism lenvatinib inhibiting enhancing...

Abstract Addressing the challenges of identifying suitable targets and effective delivery strategies is critical in pursuing therapeutic solutions for glioblastoma (GBM). This study focuses on potential microRNA-124 (miR-124), known its tumor-suppressing properties, by investigating ability to target key oncogenic pathways GBM. The results reveal that CDK4 CDK6—cyclin-dependent kinases promote cell cycle progression—are significantly overexpressed GBM brain samples, underscoring their role...

The aim of the present study was to investigate antitumor effect and mechanism action hyperforin in hepatocellular carcinoma (HCC) SK-Hep1 cells vitro. Cells were treated with different concentrations for periods time. Effects on cell viability, apoptosis signaling, expression anti-apoptotic proliferative proteins [cellular FLICE-like inhibitory protein (c-FLIP), X-linked inhibitor (XIAP), myeloid leukemia 1(MCL1), cyclin-D1] investigated by...

Amentoflavone has been shown to be effective against a variety of cancer cells, but its role in bladder remains unclear. Thus, the aim this study is evaluate whether amentoflavone may induce toxicity effect cancer.Herein, we evaluated effects human cell line TSGH8301 vitro.Amentoflavone caused significant cytotoxicity cells at concentration as low 200 μM. FAS/FASL-dependent extrinsic apoptosis and mitochondria-dependent intrinsic were observed amentoflavone-treated dose-dependent manner....

Fluoxetine, an antidepressant, has been indicated to elicit anti-cancer response in hepatocellular carcinoma (HCC) and non-small cell lung cancer (NSCLC) vitro. However, anticancer effect mechanism of fluoxetine HCC NSCLC vivo still needs be elucidated. In this study, we showed efficacy inhibitory on the tumor progression vivo. Tumor growth was significantly inhibited with treatment Fluoxetine obviously decreased expression proliferative, anti-apoptotic, invasion-associated proteins...

To study the tumor inhibition effect of mirtazapine, a drug for patients with depression, CT26/luc colon carcinoma-bearing animal model was used. BALB/c mice were randomly divided into six groups: two groups without tumors, i.e. wild-type (no drug) and (mirtazapine), four never drug), always (pre-drug, treatment before inoculation throughout experiment), concurrent (simultaneously after (post-drug, experiment). The "psychiatric" conditions observed from immobility time tail suspension...

Glioblastoma is the most common primary malignant tumor of central nervous system, with an annual incidence 5.26 per 100000 people. The clinical outcome standard therapy and survival rate remain poor; therefore, there unmet need for a new strategy to treat this lethal disease. Although amentoflavone was known have anticancer potential in various types cancers, its antiglioblastoma ability mechanism unrecognized. We demonstrated that may suppress glioblastoma invasion migration by transwell...

Abstract Glioblastomas are the most aggressive type of brain tumour, with poor prognosis even after standard treatment such as surgical resection, temozolomide and radiation therapy. The overexpression nuclear factor kappa‐light‐chain‐enhancer activated B cells (NF‐κB) in glioblastomas is recognized an important target. Thus, urgent need regarding development a new, suitable agent that may show potential for inhibition extracellular signal‐regulated kinase (ERK)/NF‐κB–mediated glioblastoma...

Background/Aim: Amentoflavone, an effective compound derived from medicinal plants, has been shown to boost therapeutic efficacy of chemotherapy in non-small cell lung cancer (NSCLC). However, anti-NSCLC effect amentoflavone is ambiguous. The major purpose the present study was verify inhibitory effects NSCLC cells. Materials and Methods: on growth invasion CL-1-5-F4 cells were evaluated by viability assay, flow cytometry, colony formation nuclear factor-kappa B (NF-κB) reporter gene...

This study suggested that lenvatinib may incapacitate hepatocellular carcinoma (HCC) to radiation treatment by abrogating radiation-induced Src/signal transducer and the activator of transcription 3 signaling (STAT3)/nuclear factor-κB (NF-κB) escalate extrinsic intrinsic apoptosis. These findings uncover role targeting Src its arbitrating epithelial-mesenchymal transition (EMT), which could increase anti-HCC efficacy therapy (RT). Lenvatinib sorafenib are multikinase inhibitors used treat...

Oral squamous cells carcinoma (OSCC) is the most common oral malignancy that majorly originated from cavity. Though prognostic and predictive value of targeting checkpoint molecules has been reported on OSCC, treatment efficacy monotherapy remaining limited. Several studies suggested multikinase inhibitors may show potential to facilitate anti-PD-L1-induced anti-tumor immunity. Regorafenib, an inhibitor approved by FDA for various types cancer treatment. Here, we aim identify whether...

The antitumor effects of curcumin, a natural biologically active compound extracted from rhizomes Curcuma longa, have been studied in many cancer cell types including human hepatocellular carcinoma (HCC). Here, we investigated the Ca(2+) on curcumin-induced apoptosis HCC J5 cells. abrogation mitochondrial membrane potential (ΔΨ(m)), increase reactive oxygen species (ROS) production, and calcium release were demonstrated with flow cytometry as early 15 minutes after curcumin treatment. In...

Anti-depressants have been reported to own anti-tumor potential types of cancers; however, the role imipramine in non-small cell lung cancer (NSCLC) has not elucidated. Epidermal growth factor receptor (EGFR) was known be one key regulators that control NSCLC progression. Whether EGFR would target for suppressing tumor signaling transduction and results is remaining unclear.We used CL-1-5-F4 cells animal models identify underlying mechanism therapeutic efficacy imipramine. Cytotoxicity,...

A previous study presented that glycyrrhizic acid as the hepatoprotective agent inhibits total parenteral nutrition-associated acute liver injury in rats. However, anticancer effect and mechanism of human hepatocellular carcinoma (HCC) is ambiguous. The purpose present was to investigate on apoptosis dysregulation metastatic potential HCC vitro vivo. Both SK-Hep1 Hep3B cells were treated with different concentrations for 24 or 48[Formula: see text]h. SK-Hep1/luc2 tumor-bearing mice vehicle...