A5053585304- COVID-19 Clinical Research Studies
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- SARS-CoV-2 and COVID-19 Research
- Circular RNAs in diseases
- SARS-CoV-2 detection and testing
- Renal and related cancers
- Genetic factors in colorectal cancer
- Long-Term Effects of COVID-19
- Advanced Glycation End Products research
- Cancer-related gene regulation
- COVID-19 and Mental Health
- Peptidase Inhibition and Analysis
- Inflammatory Biomarkers in Disease Prognosis
- Pancreatitis Pathology and Treatment
- Cancer-related molecular mechanisms research
- Eicosanoids and Hypertension Pharmacology
- Cancer, Lipids, and Metabolism
Huazhong University of Science and Technology
2020-2025
Tongji Hospital
2020-2025
Background and Aims In December 2019, an outbreak of coronavirus disease 2019 (COVID‐19) emerged in Wuhan, China. Although it has been reported that some patients with COVID‐19 showed elevated liver biochemistries, there are few studies regarding the clinical features prognosis these patients. Approach Results this multicenter, retrospective study, we collected data on laboratory‐confirmed from three hospitals China, who died or were discharged between February 1, 2020, 20, 2020. Data...
Mitochondrial transfer plays an important role in various diseases, and many mitochondrial biological functions can be regulated by HMGB1. To explore the of hepatocellular carcinoma (HCC) its relationship with HMGB1, field emission scanning electron microscopy, immunofluorescence, flow cytometry were used to detect between HCC cells. We found that cells was confirmed using tunnel nanotubes (TNTs). The mitochondria from highly invasive less could enhance migration invasion ability latter....
Background. PANoptosis has been a research hotspot, but the role of in hepatocellular carcinoma (HCC) remains widely unknown. Drug resistance and low response rate are main limitations chemotherapy immunotherapy HCC. Thus, construction prognostic signature to predict prognosis recognize ideal patients for corresponding is necessary. Method. The mRNA expression data HCC was collected from TCGA database. Through LASSO Cox regression, we developed based on PANoptosis-related genes. KM analysis...
Background: As a component of nucleosomes, histone H3 plays an important role in chromosome structure and gene expression. Current studies have mostly focused on the histones epigenetics, but addition to this, themselves tumor development microenvironment been less explored. Methods: Western blot immunofluorescence were carried out detect content localization hepatocellular carcinoma. The changes observed hypoxia treatment cells, specific action mechanism was studied by CoIP other methods....
Abstract Background Mitochondrial transfer has been found to play an important role in various diseases, and many mitochondrial biological behaviors can be regulated by HMGB1. However, the of HCC its relationship with HMGB1 are currently unknown. Method Field emission scanning electron microscope, immunofluorescence, cell flow cytometry were used detect between cells. Analyze change significance related molecules clinical samples through bioinformatics analysis tissue microarrays. The...
Background: Severe acute respiratory coronavirus 2 (SARS-CoV-2) infected pneumonia suddenly outbreak in 2019 Wuhan, China. The duration of viral RNA shedding is unclear. We aimed to analyze the and risk factors for prolonged time a large cohort.Methods: In this multicenter, retrospective, observational study, we enrolled 410 patients with SARS-CoV-2 discharged from Wuhan Union hospital, Tongji hospital Jin Yin-tan between February 1 20, 2020. Demographic characteristics, symptoms, laboratory...
Background: In December 2019, COVID-19 emerged in Wuhan, China. By 8 July 2020, the cumulative number of infected people worldwide had exceeded 11.50 million. It has been reported that a variety indicators, including lymphocytes, can predict progression disease, but clinical application value eosinophils not received widespread attention. It's specific changes course as well relationship with severity and prognosis patients, need to be further studied.Method: this multicenter, retrospective...