A5067938864- RNA modifications and cancer
- Cancer-related gene regulation
- Stochastic processes and financial applications
- Viral-associated cancers and disorders
- Cancer-related molecular mechanisms research
- Insurance, Mortality, Demography, Risk Management
- Retinal Diseases and Treatments
- Climate Change Policy and Economics
- Sperm and Testicular Function
- Microplastics and Plastic Pollution
- MicroRNA in disease regulation
- Risk and Portfolio Optimization
- Ophthalmology and Visual Impairment Studies
- Protein Hydrolysis and Bioactive Peptides
- Extracellular vesicles in disease
- Corneal surgery and disorders
- Single-cell and spatial transcriptomics
- Perovskite Materials and Applications
- RNA Research and Splicing
- Fluid Dynamics and Turbulent Flows
- Reproductive Biology and Fertility
- Anesthesia and Pain Management
- Mathematical Biology Tumor Growth
- Optical Wireless Communication Technologies
- Magnesium Oxide Properties and Applications
Northwestern Polytechnical University
2022-2024
Nanchang University
2023-2024
Sichuan Provincial Hospital of Traditional Chinese Medicine
2024
Affiliated Eye Hospital of Wenzhou Medical College
2021-2023
Wenzhou Medical University
2021-2023
Wuhan Textile University
2023
Shandong University
2019-2023
Guangdong University of Technology
2023
Sichuan Agricultural University
2019-2021
Fudan University
2020
Single-cell RNA sequencing (scRNA-seq) is a high-throughput technology performed at the level of an individual cell, which can have potential to understand cellular heterogeneity. However, scRNA-seq data are high-dimensional, noisy, and sparse data. Dimension reduction important step in downstream analysis scRNA-seq. Therefore, several dimension methods been developed. We developed strategy evaluate stability, accuracy, computing cost 10 dimensionality using 30 simulation datasets five real...
Nanoplastics (NPs) have recently emerged in the context of global plastic pollution. They may be more toxic than macroplastics litter and microplastic fragments due to its abundances, tiny sizes, cellular accessibility. The female reproductive toxicity NPs has been widely documented for aquatic animals, but their effects underlying mechanisms remain poorly understood mammals. This study aimed explore on reproduction using human ovarian granulosa cells (GCs) mice. accumulation polystyrene...
Ensuring companion animal welfare is a top priority for the pet industry and owners alike. The health of pets can be directly effectively improved through diet. Chenpi includes beneficial ingredients with proven anti-inflammatory, antioxidant, immunomodulatory properties. present investigation involved feeding snacks infused powder (CPP) to dogs 42 days examine potential benefits CPP. research evidenced notable increase in serum superoxide dismutase (SOD), catalase (CAT), glutathione...
Abstract Background Myopia is the most common visual impairment in children and adolescents worldwide. This study described an economical effective population-based screening pipeline performed project of a million scale myopia survey (CAMS), which will shed light on further from level epidemiology precision medicine. Methods We developed novel pattern, intelligent process internet-based information transmission analysis system to carry out consisting school Wenzhou, China. The examination...
In recent years, nanoplastics (NPs) and triclosan (TCS, a pharmaceutical personal care product) have emerged as environmental pollution issues, their combined presence has raised widespread concern regarding potential risks to organisms. However, the toxicity mechanisms of NPs TCS remain unclear. this study, we investigated toxic effects polystyrene on KGN cells, human ovarian granulosa cell line. We exposed cells (150 μg/mL) (15 μM) alone or together for 24 hours. Co-exposure significantly...
Abstract Background Cryopreservation induces transcriptomic and epigenetic modifications that strongly impairs sperm quality function, thus decrease reproductive performance. N 6 -methyladenosine (m A) RNA methylation varies in response to stress has been implicated multiple important biological processes, including post-transcriptional fate of mRNA, metabolism, apoptosis. This study aimed explore whether cryopreservation m A modification mRNAs associated with energy cryoinjuries,...
Dual-polarity response photodetectors (PDs) take full advantage of the directivity photocurrent to identify optical information. The dual-polarity signal ratio, a key parameter that represents equilibrium degree responses different lights, is proposed for first time. synchronous enhancement photocurrents and amelioration ratio are beneficial practical applications. Herein, based on selective light absorption energy band structure design, self-powered CdS/PEDOT:PSS/Au heterojunction PD...
Color-selective photodetectors (PDs) play an indispensable role in spectral recognition, image sensing, and other fields. Nevertheless, complex filters delicate optical paths such devices significantly increase their complexity size, which subsequently impede integration smart optoelectronic chips for universal applications. This work demonstrates the successful fabrication of filter-less color-selective perovskite PDs by integrating three units with different photoresponse on a single chip....
Background: Myopia is the most common visual impairment among Chinese children and adolescents. The purpose of this study to explore key interventions for myopia prevalence, especially early-onset high myopia. Methods: Univariate multivariate analyses were conducted evaluate potential associations between risk factor exposure LASSO was performed prioritize features, selected leading factors used establish assembled simulation model. Finally, two forecasting models constructed predict...
Purpose – The purpose of this paper is to investigate the factors that affect retail rent shopping centres in Wuhan, an important city central China. Design/methodology/approach study uses a data set 68 urban Wuhan. A regression model constructed estimate impact on composite range variables would capture physical characteristics, spatial potential attractiveness and market condition. Findings empirical findings suggest ceiling height, closeness metro line station, being situated commercial...
Post-thawed sperm quality parameters vary across different species after cryopreservation. To date, the molecular mechanism of cryoinjury, freeze-tolerance and other influential factors are largely unknown. In this study, significantly dysregulated microRNAs (miRNAs) mRNAs in boar giant panda with cryo-resistance capacity were evaluated. From result miRNA profile fresh frozen-thawed sperm, a total 899 mature, novel miRNAs identified, 284 found to be (195 up-regulated 89 down-regulated)....
miR-26a is associated with sperm metabolism and can affect motility apoptosis. However, how affects remains largely unknown. Our previous study indicated that the PDHX gene predicted to be a potential target of miR-26a, which responsible for pyruvate oxidative decarboxylation considered as key step connecting glycolysis phosphorylation. In this study, we first reported relationship between their expressions in fresh, frozen-thawed, epididymal boar sperm. Then, viability survival were...
Abstract In this paper, we consider an optimal control and stabilization problem of linear mean‐field (MF) system, where the quadratic cost functional is allowed to be indefinite. Inspired by equivalent method, introduce a subset, which helps us investigate convergence property generalized differential Riccati equations arising in indefinite (MF‐LQ) problems with finite horizon. A coupled algebraic equation (GARE) thus obtained. More importantly, solution pair corresponding GARE can...
RNA structure plays a crucial role in gene regulation, stability and the essential biological processes. secondary (RSS) motifs are basic building blocks for investigating mechanisms of structure. Here, we present strategy structural motif-based dynamic alignment, namely, secondary-structural motif-comparing (RNAsmc), to identify quantitatively evaluate their underlying molecular functions. RNAsmc also has strong robustness sequence length, folding protocol profile by chemical probing....
The health of pets is becoming a growing concern for the pet industry and its owners. Immunity one foundational supports health, thus developing functional bioactive substance that can boost pets' immunity essential. Many studies have shown casein phosphopeptide (CPP) selenium (Se) individually regulate in many species, but there has been no reported research on immunomodulatory function phosphopeptide-selenium complex (CPP-Se). objective this study was to investigate CPP-Se immunomodulation...
Abstract Transcriptional regulation is associated with complicated mechanisms including multiple molecular interactions and collaborative drive. Long noncoding RNAs (lncRNAs) have highly structured characteristics play vital roles in the of transcription organisms. However, specific contributions conformation feature underlying are still unclear. In present paper, a hypothesis regarding structure effect presented, which proposes that lncRNAs fold into complex spatial architecture act as...
Cryopreservation induces sperm cryoinjuries, including physiological and functional changes. However, the molecular mechanisms of cryoinjury cryoresistance are still unknown. Cryoresistance or freeze tolerance varies across species, boar is more susceptible to cold stress. Contrary sperm, giant panda appears be strongly freeze-tolerant capable surviving repeated cycles freeze-thawing. In this study, differentially expressed (DE) PIWI-interacting RNAs (piRNAs) fresh frozen-thawed with...
How to improve I/O performance is a significant challenge for modern scientific applications. In this paper, we present Climate Fast (CFIO), parallel library that specifically developed climate models. To minimize the required code modifications switching CFIO, provide same interface and feature as PnetCDF adopt an forwarding technique automatic overlapping of with computing. The experimental results show CFIO performs better than in terms decreasing overall running time program. By using...
We study the optimal control of fully coupled forward-backward stochastic systems with delay and noisy memory where dynamics is governed by a controlled Ito-Levy process information available to controller possibly less than overall information. Sufficient necessary maximum principles for such are derived using Malliavin calculus techniques. As an illustration, we apply result consumption problem in financial model partial
Abstract Background During arthroscopic rotator cuff repair (ARCR), clear surgical field visibility (SFV) is the basis of successful surgery, but choice anesthesia maintenance drugs may have different effects on SFV. In this study, we aimed to compare propofol- and sevoflurane-based general SFV in patients undergoing ARCR. Methods Patients ( n = 130) elective ARCR lateral decubitus position were randomized into either propofol group or sevoflurane (65 per group). The duration surgery...